Hepatitis B virus infection and the risk of cancer among the Chinese population

Tian, Ting; Song, Ci; Jiang, Longfeng; Dai, Jingjing; Lin, Yuan; Xu, Xin; Yu, Chengxiao; Ge, Zijun; Ding, Yuedi; Wen, Yiping; Liu, Bo; Shao, Yu‐Yun; Shi, Peng; Zhu, Chuanlong; Liu, Yuan; Jing, Shenqi; Wang, Zhongmin; Hu, Zhibin; Li, Jun

doi:10.1002/ijc.33130

Cited by 56 publications

(66 citation statements)

References 30 publications

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“…Moreover, our rate of HCC patients with HBs Ag positive was 64.4% which is almost 6-fold higher than that in the United States (10%) [20]. In China, HCC are associated with cirrhosis related to chronic HBV infection in most cases [21,22]. And sustained inflammation and chronical injury can upregulate Fign mRNA expression [9].…”

Section: Discussionmentioning

confidence: 70%

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Fidgetin as a potential prognostic biomarker for hepatocellular carcinoma

Zhou¹,

Wang²,

Gao³

et al. 2020

Int. J. Med. Sci.

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Background: Fidgetin (FIGN), a conserved ATP-dependent enzyme, is regarded as a hepatocellular carcinoma (HCC) risk gene, but the prognostic implication of FIGN in HCC remains obscure. In this study, we investigate the expression of FIGN in HCC and to evaluate its prognostic value. Methods: A total of 216 patients with HCC who experienced hepatectomy were recruited in this study. The expression of FIGN in HCC samples was evaluated by quantitative real-time PCR, immunohistochemistry and immunoblotting analysis. And Cox regression model was used to evaluate the prognostic value of all covariates. Results: Of the 216 HCC patients, 67 (31.0%) had tumors with high FIGN expression and 149 (69.0%) had tumors with low FIGN expression. FIGN expression was positively correlated with TNM stage (P = 0.039), tumor with incomplete capsule (P = 0.036), microvascular invasion (P = 0.023), and portal vein tumor thrombus (P = 0.003). High expression of FIGN indicated shorter overall survival (OS) (hazard ratio: 4.569, P = 0.036) and disease-free survival (DFS) (hazard ratio: 6.487, P = 0.001). Conclusion: Our results indicate that high Fidgetin expression is associated with tumor progression and suggest a worse prognosis in HCC. Fidgetin might serve as a potential target for therapy.

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Section: Discussionmentioning

confidence: 70%

“…The tumor physiological features are quite different. HBV-related HCC is the largest proportion of patients with HCC in China [22], while alcohol consumption and nonalcoholic steatohepatitis are the leading causes of HCC in America [21]. Thus, these inconsistent results are possibly due to the differences in demographic and HBV infection.…”

Section: Discussionmentioning

confidence: 99%

Fidgetin as a potential prognostic biomarker for hepatocellular carcinoma

Zhou¹,

Wang²,

Gao³

et al. 2020

Int. J. Med. Sci.

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“…Moreover, in intrahepatic cholangiocarcinoma, the incidence of LNM in patients with HBV infection is lower than that in patients without HBV infection, which has been con rmed in some studies (24). Recent studies have reported that HBsAg positivity is also associated with the incidence and progression of other malignancies, such as gastric, esophageal, and pancreatic cancers (25). The increase in serum globulin is associated with a variety of chronic in ammatory diseases, and the increase in in ammatory cytokines in serum globulin contributes to the increase in serum albumin and the inhibition of serum albumin biosynthesis (26).…”

Section: Discussionmentioning

confidence: 85%

Nomogram Based on Preoperative Clinical Characteristics to Predict the Risk of Lymph Node Metastasis in Hepatocellular Carcinoma

Wei¹,

S²,

Ren³

et al. 2020

Preprint

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Background: There are limitations in judging the occurrence of lymph node metastasis (LNM) in hepatocellular carcinoma (HCC) before surgery. The purpose of this study was to establish a preoperative nomogram for predicting the risk of LNM in HCC and to explore its clinical utility.Methods: A total of 195 HCC patients undergoing radical hepatectomy were retrospectively analyzed. According to the presence or absence of LNM, the patients were divided into two groups, and the clinical characteristics of the two groups were compared. Risk factors for LNM were assessed based on logistic regression, and a nomogram was established. The receiver operating characteristic (ROC) curve was used to calculate area under the curve (AUC) of the logistic regression model, and the predictive accuracy of the nomogram was evaluated by the concordance index (C-index). The clinical efficacy of the nomogram was detected by decision curve analysis (DCA).Results: Logistic analysis revealed hepatitis B surface antigen (HBsAg) (HR = 3.50, 95% CI, 1.30-9.42, P = 0.013), globulin (HR = 2.46, 95% CI, 1.05-5.75, P = 0.039), neutrophil to lymphocyte ratio (NLR) (HR = 7.64, 95% CI, 3.22-18.11, P < 0.001) and tumor size (HR = 3.86, 95% CI, 1.26-11.88 P = 0.018) were independent risk factors for lymph node metastasis in HCC. The nomogram was established based on the above 4 variables, and the AUC was 0.835 (95% CI, 0.780-0.890). The calibration curve showed that the model has good predictive ability, and DCA indicates good predictive effect.Conclusions: The nomogram established by analyzing the preoperative clinical characteristics is a simple tool that can predict the risk of lymph node metastasis in HCC patients and guide clinicians to make better clinical decisions.

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“…Information on general demographic and clinicopathological variables suspected to be risk factors for survival was collected for each patient. Hepatitis B virus (HBV) infection was defined by HBV sero-markers or a history of antiviral HBV treatment 28 . Hepatitis C virus (HCV) infection was confirmed by HCV-Ab positivity or a history of antiviral HCV treatment.…”

Section: Methodsmentioning

confidence: 99%