Hepatitis B Virus Infection and the Risk of Coronary Atherosclerosis

Ghotaslou, Reza; Aslanabadi, Nasser; Ghojazadeh, Morteza

doi:10.47102/annals-acadmedsg.v37n11p913

Cited by 16 publications

(1 citation statement)

References 22 publications

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“…However, the literature presents con icting results on the association between hepatitis B infection and atherosclerosis. Some studies suggest a strong association between NASH, HCV, HBV, and early atherosclerosis independent of traditional risk factors, while others suggest no correlation between hepatitis B virus infection and coronary atherosclerosis in certain populations [11] [12]. Thus, the objective of this study was to assess the relationship between hepatitis B infection and abdominal aortic calci cation among a representative sample of individuals from the National Health and Nutrition Examination Survey (NHANES).…”

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confidence: 99%

Association Between Past Hepatitis B Infection and abdominal aorta calcification: National Health and Nutrition Examination Survey

Zhang

Cao

et al. 2023

Preprint

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Introduction: With mounting evidence, there is a postulation that Hepatitis B Infection may be a risk factor for atherosclerotic diseases. Abdominal aortic calcification (AAC) has been found to be significantly associated with subclinical atherosclerotic diseases. Our objective was to investigate the relationship between Hepatitis B core antibody and abdominal aortic calcification. Methods: In this cross-sectional observational study, data from the National Health and Nutrition Examination Survey (NHANES) conducted during 2013–2014 were utilized to investigate the relationship between Hepatitis B core antibody and AAC. The study used dual-energy X-ray absorptiometry to measure AAC and evaluated it using the Kauppila score system. The variable LBXHBC of the NHANES dataset was reviewed to identify patients with positive Hepatitis B core antibody. To assess the association between Hepatitis B core antibody and AAC, multivariate logistic regression mixed models and subgroup analyses were conducted. Results: The 2013–2014 data showed documentation of 288 patients with positive Hepatitis B core antibody. After adjusting for multiple variables, the multivariable odds ratios (95% CI) revealed that severe AAC was correlated with Hepatitis B infection (OR = 1.52, 95%CI [1 ~ 2.3]; p = 0.05), as opposed to the no Hepatitis B group. However, this association was not observed among individuals with mild AAC (OR = 1.22, 95%CI [0.9 ~ 1.65]; p = 0.205). Results were consistent in multiple subgroup and sensitivity analyses. Conclusions: Individuals who tested positive for Hepatitis B core antibody had a higher likelihood of severe AAC compared to those who tested negative, while no significant association was observed among individuals with mild AAC.

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Section: Introductionmentioning

confidence: 99%

Association Between Past Hepatitis B Infection and abdominal aorta calcification: National Health and Nutrition Examination Survey

Zhang

Cao

et al. 2023

Preprint

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Evaluation of the serum levels of Mannose binding lectin‐2, tenascin‐C, and total antioxidant capacity in patients with coronary artery disease

Mehri

Aslanabadi

Nourazarian

et al. 2021

Clinical Laboratory Analysis

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Influenza virus aggravates the ox-LDL-induced apoptosis of human endothelial cells via promoting p53 signaling

et al. 2015

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Oxidized low-density lipoprotein (ox-LDL) is well recognized to play a key role in the development of atherosclerosis. And influenza virus infection has been also recognized to promote the atherosclerosis onset and progressing. However, little is known about the mechanism into it. In present study, we investigated the infection of A/Porto Rico/8/1934 (H1N1) (PR8) influenza virus in human endothelial Eahy926 cells, and determined the induction of apoptosis by the virus infection in the cell. Then we investigated the apoptosis induced by ox-LDL in Eahy926 cells, determined the influence of influenza virus infection on the ox-LDL-induced apoptosis in Eahy926 cells. Results demonstrated that PR8 virus infected human endothelial Eahy926 cells, forming plaques and replicated efficiently in the cell. And the virus infection promoted apoptosis in the cell, upregulated cytchrome c release, activated caspase 3. And what's more, we found that combined PR8 virus infection and ox-LDL treatment promoted higher level of apoptosis and higher level of the activation of apoptosis-associated molecules. Further examination indicated that the p53 signaling was more significantly promoted by both treatments. Therefore, present study confirmed that influenza virus aggravated the ox-LDL-induced apoptosis of human endothelial Eahy926 cells via promoting p53 signaling.

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Hepatitis B Virus Infection and the Risk of Coronary Atherosclerosis

Cited by 16 publications

References 22 publications

Association Between Past Hepatitis B Infection and abdominal aorta calcification: National Health and Nutrition Examination Survey

Association Between Past Hepatitis B Infection and abdominal aorta calcification: National Health and Nutrition Examination Survey

Evaluation of the serum levels of Mannose binding lectin‐2, tenascin‐C, and total antioxidant capacity in patients with coronary artery disease

Influenza virus aggravates the ox-LDL-induced apoptosis of human endothelial cells via promoting p53 signaling

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