Hepatitis B virus infection combined with nonalcoholic fatty liver disease: Interaction and prognosis

Liu, Huan; Li, Hong; Zhang, Yang; Zhang, Jing; Cao, Zhenhuan

doi:10.1016/j.heliyon.2023.e13113

Cited by 10 publications

(1 citation statement)

References 70 publications

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“…Similar to helminth infections, chronic hepatitis resulting from HBV or HCV has also been linked to MetS-related factors and SLD [ 33 ]. HBV has been inversely associated with the development of MetS and hepatic steatosis, whereas HCV infection has not shown the same association [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Steatotic liver disease among lean and non-lean individuals in Southern Lao PDR: a cross-sectional study of risk factors

Homsana,

Southisavath,

Kling

et al. 2024

Annals of Medicine

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Background Steatotic liver disease (SLD) prevalence is rising worldwide, linked to insulin resistance and obesity. SLD prevalence can surpass 10% even among those with normal weight. In Lao People’s Democratic Republic (Lao PDR), where Opisthorchis viverrini (OV) trematode infection and type 2 diabetes mellitus (T2DM) are common, infection related liver morbidity such as cholangiocarcinoma (CCA) is high, but data on SLD prevalence is lacking. The objective of this study was to estimate the prevalence and explore determinants of SLD in rural southern Lao PDR for lean and non-lean populations. Method A cross-sectional community-based study assessed SLD prevalence using abdominal ultrasonography (US). Factors investigated for association with SLD were identified by interview, serological tests (Hepatitis B surface antigen (HBsAg); lipids and HbA1c), anthropometrical measurements, and parasitological assessments (OV infection). Uni- and multivariable logistic regression analyses with SLD as endpoint were conducted separately for lean (body mass index (BMI) <23.0 kg/m 2 ) and non-lean (BMI ≥ 23.0 kg/m 2 ) participants. Result 2,826 participants were included. SLD prevalence was 27.1% (95% confidence interval (95% CI) 24.0%−30.4%), higher among non-lean (39.8%) than lean individuals (17.4%). Lean individuals with OV infection had a statistically significant association with lower odds of SLD (adjusted odds ratio (aOR) 0.49, 95% CI 0.33 − 0.73). T2DM showed a significant positive association with SLD in both lean (aOR 3.58, 95% CI 2.28 − 5.63) and non-lean individuals (aOR 3.31, 95% CI 2.31 − 4.74) while dyslipidemia was significantly associated only in the non-lean group (aOR 1.83, 95% CI 1.09 − 3.07). Females participants exhibited elevated odds of SLD in both lean (aOR 1.43, 95% CI 1.02 − 2.01) and non-lean SLD (aOR 1.50, 95% CI 1.12 − 2.01). Conclusion SLD prevalence is notably high among Laotian adults in rural areas, particularly in females and in non-lean individuals. Lean individuals with OV infection exhibited lower SLD prevalence. SLD was more prevalent in individuals with T2DM, independent of BMI. SLD adds to the burden of infection-related liver morbidity in Lao PDR.

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Section: Discussionmentioning

confidence: 99%

Steatotic liver disease among lean and non-lean individuals in Southern Lao PDR: a cross-sectional study of risk factors

Homsana,

Southisavath,

Kling

et al. 2024

Annals of Medicine

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The hepatic steatosis, steatohepatitis and metabolic dysfunction: distinct roles in hepatocellular carcinoma occurrence in chronic hepatitis B patients

Hu,

Wen

2024

Hepatol Int

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Prospective appraisal of clinical diagnostic algorithms for hepatocellular carcinoma surveillance in Chinese patients with chronic hepatitis B infection

Chan,

Hu,

Malinowsky

et al. 2024

Sci Rep

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Hepatocellular carcinoma (HCC) is often detected at advanced stages among patients with hepatitis B virus (HBV), underscoring the urgency for more precise surveillance tests. Here, we compare the clinical performance of the novel - GAAD (gender [biological sex], age, alpha-fetoprotein [AFP], protein-induced by vitamin K absence-II [PIVKA-II]) and GALAD (gender [biological sex], age, AFP, Lens-culinaris AFP [AFP-L3]), PIVKA-II) algorithms to assess the utility of AFP-L3 for distinguishing HCC from benign chronic liver disease (CLD) in Chinese patients with predominantly chronic HBV infection. Eligible adults were enrolled, and biomarkers were measured using Elecsys (Cobas) or µTASWAKO assays. In total, 411 participants provided serum samples (HCC, n = 176 [early-stage, n = 110]; CLD, n = 136; specificity n = 101). HBV was the underlying disease etiology for most participants (HCC, 95%; benign CLD, 72%). For GAAD (Cobas), GALAD (Cobas), and GALAD (µTASWAKO), AUCs were 93.1% (95% CI: 90.0–96.2), 93.2% (90.0–96.3), and 92.7% (88.4–96.9) for early-stage, and 95.6% (93.6–97.6), 95.6% (93.6–97.7), and 95.8% (93.2–98.3) for all-stage HCC, versus CLD, respectively. Interestingly, both GAAD and GALAD algorithms demonstrated comparable diagnostic performance regardless of disease etiology (HBV vs. non-HBV), presence of cirrhosis, geographic region, and within pan-tumor specificity panels (p < 0.001), indicating AFP-L3 may have a negligible role in HCC surveillance.

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Hepatitis B virus infection combined with nonalcoholic fatty liver disease: Interaction and prognosis

Cited by 10 publications

References 70 publications

Steatotic liver disease among lean and non-lean individuals in Southern Lao PDR: a cross-sectional study of risk factors

Steatotic liver disease among lean and non-lean individuals in Southern Lao PDR: a cross-sectional study of risk factors

The hepatic steatosis, steatohepatitis and metabolic dysfunction: distinct roles in hepatocellular carcinoma occurrence in chronic hepatitis B patients

Prospective appraisal of clinical diagnostic algorithms for hepatocellular carcinoma surveillance in Chinese patients with chronic hepatitis B infection

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