Hepatitis B Virus infection in HIV-positive population in Brazil: results of a survey in the state of Mato Grosso and a comparative analysis with other regions of Brazil

Abstract

Background: End-stage liver disease is currently a major concern among HIV-positive individuals due to co-infection with hepatotropic virus. Hepatitis C has been pointed out as a remarkable factor for that. More recently, hepatitis B virus (HBV) infection has also been found to play a role on liver disease in this population. HIV-HBV co-infection prevalence remains largely unknown in vast areas of Brazil. The objective of the present study was to estimate the prevalence of HBV and HDV infection in HIV-infected subjects living in the state of Mato Grosso, in the Central region of Brazil, and compare it to other Brazilian studies. We also assess epidemiologic data regarding risk factors and vaccinal status.

Prevalence, risk factors and genotypes of hepatitis B infection among HIV-infected patients in the State of MS, Central Brazil

“…The prevalence of HBV infection among HIV-infected patients measured in this study (26.2%) was lower than those reported in sub-Saharan Africa (59.8%), 16 Chile (46.3%), 17 Cuba (45.5%) 18 and in different regions of Brazil, which ranges from 30.0% to 55.1%. 4,5,7,19,20 The prevalence of HIV-HBV coinfection (2.5%) in the present study was lower than those reported in different regions of Brazil (5.7%, 8.5%, and 18%). 4,5,21 In addition, our results were in line with the prevalence of HIV-HBV coinfection from the state of Mato Grosso, also located in Central-West Region of Brazil.…”

“…4,5,21 In addition, our results were in line with the prevalence of HIV-HBV coinfection from the state of Mato Grosso, also located in Central-West Region of Brazil. 20 In the population-based multicentric survey of hepatitis B infection conducted in urban area of Central-West Region of Brazil, the region was classified as a low HBV endemic area based on the encountered prevalence. 22 On the other hand, remote sites highly endemic for HBV have been reported in the Afro-descendant communities in Central-West, even in Mato Grosso do Sul state.…”

Hepatitis B, C seroprevalence and delta viruses in HIV‐1 Senegalese patients at HAART initiation (retrospective study)

“…Our study, like many others, has demonstrated that men are more frequently carriers of the HBs antigen than women, with respectively 23.4% and 11.5% but with no significant difference across age groups [Ockenga et al, 1997;de Almeida Pereira et al, 2006].…”

“…A study carried out in the state of Mato Grosso in Central Brazil indicated that 40% of a cohort of 1,000 HIV infected patients was positive for anti-HBc Ab. This rate is fourfold higher among blood donors [de Almeida Pereira et al, 2006]. Similarly, studies in developed countries with low levels of HBV had demonstrated that 6-14% of chronic HBV infection occurs among PLwHIV [Alter, 2006].…”

Occult hepatitis B virus infection in HIV‐infected patients: Evaluation of biochemical, virological and molecular parameters

“…In Brazil, information on HBsAg seropositivity among HIV‐infected patients is still limited. Available data have reported prevalence of HIV‐HBV co‐infection ranging from 3.7 to 24.3% 30–34 . HIV co‐infection is associated with higher chronicity rate of HBV infection, 35 higher levels of HBV replication, 36 milder necro‐inflammatory activity, 37 and a more rapid progression to cirrhosis 38 .…”