Hepatitis B Virus Infection is a Prognostic Biomarker for Better Survival in Operable Esophageal Cancer: Analysis of 2,004 Patients from an Endemic Area in China

Zou, Jianyong; Chen, Junying; Xie, Xuan; Liu, Zhengguo; Cai, Xiaoli; Liu, Qianwen; Wen, Jing; Zhang, Shuishen

doi:10.1158/1055-9965.epi-18-1095

Cited by 9 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is noteworthy that in our study, HBsAg did not increase the rate of liver metastases for very young patients with breast cancer. This results are comparable to those reported in previous studies for esophageal cancer and colorectal cancer (20,31), which suggested that HBV infection is associated with decreased risk of liver metastasis in these malignancies. Our study shows that HBsAg-positive status is associated with inferior DFS and OS in young patients with curatively resected breast cancer, decreasing the 10-year DFS and OS by 6.7 and 12.6%, respectively.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

“…The association between HBsAg-positive status and poor prognosis is in keeping with that demonstrated in nasopharyngeal carcinoma ( 32 ), lung cancer ( 19 ), and ovarian cancer ( 21 ). However, some studies regarding other cancers indicate that HBsAg-positive cancer patients had a favorable survival as compared with HBsAg-negative patients ( 20 , 31 ). This discrepancy can be partly explained by the diversity and heterogeneity of different malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…HBV is the leading cause of hepatocellular carcinoma and cholangiocarcinoma (12,13). In addition, there is also accumulating evidence that HBV infection is associated with many extrahepatic malignancies (14), including non-Hodgkin's lymphoma (15), pancreatic cancer (16), gastric cancer (17), nasopharyngeal carcinoma (18), lung cancer (19), esophageal cancer (20), and ovarian cancer (21). Thus, it seems reasonable that HBV is an important factor in the development of extrahepatic malignancies in endemic areas.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic Value of Hepatitis B Virus Infection in Very Young Patients With Curatively Resected Breast Cancer: Analyses From an Endemic Area in China

Zhong

Yang

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

Background: Hepatitis B virus (HBV) infection has been associated with the risk and prognosis of many malignancies. Nevertheless, the association between HBV and the prognosis of breast cancer is unclear. The objectives of this study were to investigate the prognostic role of hepatitis B surface antigen (HBsAg) and to integrate HBsAg to establish nomograms for better prognostic prediction of very young patients with breast cancer. Methods: This analysis was performed retrospectively in a cohort of 1,012 consecutive very young (≤35 at diagnosis) patients who received curative resection for breast cancer. The significance of HBsAg in the prognosis of these patients was investigated. Univariate and multivariate analyses were used to identify independent variables for disease-free survival (DFS) and overall survival (OS). Nomograms were built based on those identified variables. Conclusions: HBsAg is an independent unfavorable prognostic factor for DFS and OS in very young patients with curatively resected breast cancer, and nomograms integrating HBsAg provide individual survival prediction to benefit prognosis evaluation and individualized therapy.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic Value of Hepatitis B Virus Infection in Very Young Patients With Curatively Resected Breast Cancer: Analyses From an Endemic Area in China

Zhong

Yang

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…We identified consecutive patients with esophageal cancer who underwent radical surgery for esophageal carcinoma at Sun Yat-sen University Cancer Center between December 2000 and December 2008 [15]. Patients who had received neoadjuvant or adjuvant therapy, had a history of other cancer, lacked weight loss date were excluded.…”

Section: Patientsmentioning

confidence: 99%

Preoperative weight loss is associated with poorer prognosis in operable esophageal cancer patients: A single-center retrospective analysis of a large cohort of Chinese patients

Zhang¹,

Tan²,

Cai³

et al. 2020

J. Cancer

Self Cite

View full text Add to dashboard Cite

Background: Preoperative weight loss has been shown to be a prognostic factor for many cancers. However, whether preoperative weight loss has clinical significance in patients with esophageal cancer is still controversial. Methods: A total of 2,174 Chinese patients underwent radical resection of esophageal cancer from 2000 to 2008 were included in our study. Patients were divided into two group: no weight loss (-) and weight loss (+), according to whether they had weight loss compared with their usual weight at diagnosis. The influence of preoperative weight loss on disease-free survival (DFS) and overall survival (OS) was estimated using the Kaplan-Meier method and Cox proportional hazard models. Results: weight loss (+) was significantly associated with age (P=0.001), alcoholism (P<0.001), tumor location (P=0.003), pT category (P=0.003), pN category (P=0.001). Patients of group weight loss (+) had significantly poorer DFS (Mean: 63.3 months (m) vs 76.8 m, P<0.001) and OS (67.4 m vs 83.3 m, P<0.001) than the no weight loss (-) group. In the final multivariate survival analysis with adjustment for covariates, we found that the weight loss (+) group had a 19% higher risk of death (HR=1.19, 95%CI: 1.07-1.33, P=0.002) and had a 13% higher risk of disease progression (HR=1.13, 95%CI: 1.01-1.25, P=0.027), respectively, than the no weight loss (-) group. Subgroup analysis indicated that the association with preoperative weight loss and better DFS or OS was observed in patients with esophageal squamous cell carcinoma (ESCC) and early pathological stage (I-II). Conclusion: Preoperative weight loss is associated with shorter OS and DFS, which means poor postoperative prognosis in esophageal cancer patients.

show abstract

Survival outcomes of patients with head and neck squamous cell cancer with hepatitis B virus infection: An analysis from an endemic tertiary center

Lai

Lin

et al. 2022

Cancer Medicine

View full text Add to dashboard Cite

Background Hepatitis B virus (HBV) affects the occurrence and survival outcome of various malignant disorders. The study aimed to evaluate the survival outcome of head and neck squamous cell cancer (HNSCC) patients with or without HBV infection. Methods This study included patients with HNSCC who visited Taichung Veterans General Hospital from 2007 to 2015. HBV infection was defined by hepatitis B surface antigen (HBsAg) seropositivity. By propensity score matching, we compared survival outcomes, including progression‐free survival (PFS) and overall survival (OS), among patients with or without HBV infection. Results The prevalence of HBV infection in our cohort was 12.3%. Among the 1,015 patients included in the matched analysis, a higher risk of baseline liver cirrhosis (11.3% vs. 3.4%, p < 0.001) and initial hepatic dysfunction (10.8% vs. 5.4%, p = 0.005) rates were observed than those without HBV infection at baseline. The 5‐year OS was 43.1% and 53.2% ( p < 0.001) and the 5‐year PFS was 37.4% and 42.3% ( p = 0.007) in patients with and without HBV infection, respectively. The incidence of subsequent hepatic dysfunction showed no difference between patients with and without HBV infection (29.6% vs. 26.8%, p = 0.439). Conclusions Patients with HNSCC and HBV infection were younger and had a higher risk of cirrhosis compared to those without HBV infection. Moreover, HBV infection significantly influenced the OS and PFS outcomes but not subsequent hepatic dysfunction in patients with HNSCC.

show abstract

Hepatitis B Virus Infection is a Prognostic Biomarker for Better Survival in Operable Esophageal Cancer: Analysis of 2,004 Patients from an Endemic Area in China

Cited by 9 publications

References 21 publications

Prognostic Value of Hepatitis B Virus Infection in Very Young Patients With Curatively Resected Breast Cancer: Analyses From an Endemic Area in China

Prognostic Value of Hepatitis B Virus Infection in Very Young Patients With Curatively Resected Breast Cancer: Analyses From an Endemic Area in China

Preoperative weight loss is associated with poorer prognosis in operable esophageal cancer patients: A single-center retrospective analysis of a large cohort of Chinese patients

Survival outcomes of patients with head and neck squamous cell cancer with hepatitis B virus infection: An analysis from an endemic tertiary center

Contact Info

Product

Resources

About