Hepatitis B Virus Serological Profile and Associated Risk Factors in Surface Antigen Negative Blood Donors in Nigeria

Osuji, Ahaneku Iherue; Agbakoba, Nneka Regina; Ifeanyichukwu, Martin; Abdullahi, Idris Nasir; Ezeanya-Bapka, Chinyere Charity; Duru, Georgina Chinenye

doi:10.21608/mid.2020.33141.1025

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…This means any person can be infected irrespective of the blood group he belonged. This agrees with the study of Osuji et al [23] that recorded high attendance of blood group O (73.6%) in a study at two tertiary hospitals in Nigeria.…”

Section: Discussionsupporting

confidence: 93%

Detection of Hepatitis C Virus Antibodies among Healthy Blood Donors at a Tertiary Hospital in Nigeria

Osuji

Duru

Kinjir³

2020

Microbes and Infectious Diseases

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Background: Most blood transfusion centres in Nigeria including the University of Abuja Teaching Hospital (UATH), Gwagwalada, Abuja use rapid test kit for screening blood donors. Though it is simple, robust with speedy results, it has some limitations. This cross-sectional study determined the prevalence of hepatitis C virus (HCV) antibodies by the currently used rapid detection assay among blood donors tested positive by enzyme-linked immunosorbent assay (ELISA) and described the HCV risk factors and socio-demographic characters among the blood donor participants. Methods: Blood samples were collected from 365 blood donors attending UATH blood bank, screened for HCV antibodies using ELISA kit (CTK Biotech, USA). Positive samples were retested using Aria rapid test kit. Structured questionnaires were used to collate subjects' socio-demographic data and risk factors of infection. Results: Out of 365 blood donors tested, 55 (15.1%) were positive for HCV antibodies. Of the 55 ELISA positive samples, 9(16.4%) samples were negative by Aria rapid test kit. Sociodemographic data showed that females had a higher prevalence (16.3%) than males (14.9%) (p= 0.81). The age group with the highest rate of infection was 31-45 years (p<0.0001). Marital status of the blood donors was significantly associated with HCV seropositivity, as singles were more infected than married blood donors (p<0.0001). The most predictive risk factors associated with the HCV infection among blood donors at UATH included lack of knowledge of HCV, sharp and needle injury and tribal marks. Conclusion/Recommendations: The study revealed the superiority of ELISA over Aria rapid test kit in the detection of HCV antibodies. The missed positive cases by the currently used rapid test could pose a risk to blood transfusion safety and necessitates for preventive measures to be intensified, as blood donors with high risk factors be deferred from blood donation to reduce HCV transfusion risk in Nigeria.

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Section: Discussionsupporting

confidence: 93%

Detection of Hepatitis C Virus Antibodies among Healthy Blood Donors at a Tertiary Hospital in Nigeria

Osuji

Duru

Kinjir³

2020

Microbes and Infectious Diseases

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“…This method produces monodisperse round gold nanoparticles within the extend of 10-20 nm in distance across. Be that as it may, the blend of bigger gold nanoparticles with distances across between 30 and 100 nm was detailed by Brown and Natan through seeding of Au3+ by hydroxylamine [15]. Consequent inquire about driven to the adjustment of the shape of these gold nanoparticles coming about in bar, triangular, polygonal bars, and circular particles.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Nanotechnology: Current trends in detections of microbial pathogens

Maria Adewole

2023

Int. J. Sci. Res. Arch.

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The circulation of pathogens in developing countries is one of the major causes of infectious disease outbreaks. Currently, there are limitations to already existing methods for microbial pathogen detection. A significant number of pathogens are left undetected via of conventional methods. The detection methods that are innovative, rapid with high sensitivity and specificity are required to target pathogens. This will aid to overcome present drawbacks in disease management. Nanotechnology is a recent advancements leading to the development of nanoparticle-based assay for detection of specific pathogens. Gold nanoparticles are known to have unique and high surface area. This makes them an ideal candidate for pathogen specific detection. The gold nanoparticles have unique physicochemical properties which are more advantageous over existing conventional detection methods. This review focused on the application of nanotechnology in microbial pathogen detection. With an insight on the exploration of nanotechnology to overcome the limitation of existing detection methods.

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Hepatitis B Virus Serological Profile and Associated Risk Factors in Surface Antigen Negative Blood Donors in Nigeria

Abstract: Background: This cross-sectional study investigated the serological profile, sociodemographic characters and risk factors of hepatitis B virus (HBV) infection among HBV surface antigen (HBsAg)-negative blood donors at the

Cited by 2 publications

References 16 publications

Detection of Hepatitis C Virus Antibodies among Healthy Blood Donors at a Tertiary Hospital in Nigeria

Detection of Hepatitis C Virus Antibodies among Healthy Blood Donors at a Tertiary Hospital in Nigeria

Nanotechnology: Current trends in detections of microbial pathogens

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