Hepatitis B virus vaccine immune response and mortality in dialysis patients: a meta-analysis

Liver Morbidity in Patients Negative for Overt HBV and HCV Undergoing Maintenance Hemodialysis: a Hospital-based Study

“…Infection after successful vaccination has been reported and usually results in reactivity to HBcAb and boosting the titer of HBsAb [45]. The e cacy of hepatitis B vaccination of HD patients in this study who were negative to HBcAb (62%) is comparable to 69% reported in a large meta-analysis study [46].…”

Immunogenicity of SARS-CoV-2 Vaccine in Dialysis

“…12 The combined deficits in Tcell, APC and B-cell functions render dialysis patients less likely to both seroconvert and maintain protective titers over time compared to individuals without kidney disease, 13 previously observed with pneumococcal, hepatitis-B and H1N1 influenza vaccines. 7,8,14 Factors associated with poor seroconversion in our cohort include female sex, younger vintage, potential immunosuppression from diseases, transplant or medications, CHF and co-vaccination and hospitalization during the peri-vaccination period. A recent meta-analysis suggests women receiving dialysis respond to vaccines equally to men, although differences in seroconversion rates by sex were noted in some hepatitis-B series.…”

“…1,2 Patients receiving maintenance dialysis (henceforth "dialysis patients"), particularly those receiving hemodialysis, comprise a population of vulnerable individuals who cannot self-isolate, have a high incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and have Coronavirus Disease 2019 (COVID-19)associated mortality of 15 to 25%, [3][4][5] making effective vaccination a priority. Despite this heightened risk and prior reports of diminished response to vaccines versus other viruses such as hepatitis-B and influenza, [6][7][8] the immune response to SARS-CoV-2 vaccination among dialysis patients is unknown due to insufficient trial data. Accordingly, we performed a quality improvement evaluation of multiple Dialysis Clinic, Inc. (DCI) dialysis clinics in the US assessing antibody response following administration of SARS-CoV-2 messenger RNA (mRNA) vaccines.…”

Viral hepatitis in patients on hemodialysis

“…Key tools for prevention of viral hepatitis transmission include vaccination, screening, and treatment. The HBV immunization vaccine has been associated with a global decrease in HBV incidence and is the most effective preventive intervention against HBV transmission 21,34,35 . CDC guidelines recommend that all healthcare workers be vaccinated against HBV, and if chronically infected, following universal precautions is sufficient for infection control 36 .…”

“…However, this is still lower than the 90%‐95% protection rates reached in the general adult population 21 . It is important to vaccinate patients with chronic kidney disease early because their ability to achieve immunological protection with the HBV vaccine decreases with disease progression 21,34,40 . Higher glomerular filtration rate is associated with better vaccine response 21 .…”