Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF‐1

Cho, Hyun Kook; Kim, So Young; Seong, Je Kyung; Cheong, JaeHun

doi:10.1016/j.febslet.2014.01.017

Cited by 12 publications

(8 citation statements)

References 32 publications

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“…One such chemokine involved is stromal cell-derived factor-1 (SDF-1), which is induced by HBx via endoplasmic reticulum stress. The recruited immune cells in the liver will engender a more severe chronic hepatitis [ 22 ].…”

Section: Pathwaysmentioning

confidence: 99%

Hepatitis B Virus X Protein and Hepatocarcinogenesis

Shuaichen

Koh

Lee

2016

IJMS

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Chronic hepatitis B virus (HBV) infection is one of the most associated factors in hepatocarcinogenesis. HBV is able to integrate into the host genome and encode the multi-functional hepatitis B virus x protein (HBx). Although the mechanism between HBx and carcinogenesis is still elusive, recent studies have shown that HBx was able to influence various signaling pathways, as well as epigenetic and genetic processes. This review will examine and summarize recent literature about HBx’s role in these various processes.

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Section: Pathwaysmentioning

confidence: 99%

Hepatitis B Virus X Protein and Hepatocarcinogenesis

Shuaichen

Koh

Lee

2016

IJMS

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“…Biliary epithelial cells secrete CXCL12, and the increased expression of this ligand in interlobular and septal bile ducts and proliferated bile ductules can recruit inflammatory and immune cells to the inflamed liver . The CXCL12/CXCR4 axis has been implicated in the migration of immune cells to the liver in patients with chronic hepatitis B and C, PBC, PSC and autoimmune hepatitis . CXCL14 has been proposed as a natural inhibitor of CXCL12, and CXCR7 may also naturally modulate this pro‐inflammatory axis .…”

Section: Chemokine Ligands and Receptors In Autoimmune Hepatitismentioning

confidence: 99%

Review article: chemokines as orchestrators of autoimmune hepatitis and potential therapeutic targets

Czaja

2014

Aliment Pharmacol Ther

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Summary Background Chemokines contribute to the pathogenesis of autoimmune hepatitis by directing the migration and positioning of inflammatory and immune cells within the liver. Aim Describe the liver‐infiltrating effector cell populations in autoimmune hepatitis, indicate the chemokines that influence their migration, describe the role of chemokines in hepatic fibrosis and identify chemokine‐directed treatment opportunities. Methods Studies cited in Pub Med from 1972 to 2014 for autoimmune hepatitis, chemokines in liver disease, pathogenesis of autoimmune hepatitis and chemokine therapy were selected. Results T helper type 17 lymphocytes expressing CXCR3 and CCR6 are attracted to the liver by the secretion of CXCL9, CXCL10 and CXCL11. These cells recruit pro‐inflammatory T helper type 1 lymphocytes expressing CXCR3 and CCR5 by secreting CXCL10. Resident natural killer T cells expressing CXCR6 migrate in response to the local secretion of CXCL16, and they modulate the inflammatory response. T helper type 2 lymphocytes expressing CCR4 are attracted by CCL17 and CCL22, and they dampen the expansion of pro‐inflammatory cells. Regulatory T cells expressing CXCR3 are attracted by the secretion of CXCL9, and they help dampen the pro‐inflammatory responses. CCL2, CCL3, CCL5, CXCL4, CXCL10 and CXCL16 promote fibrosis by activating or attracting hepatic stellate cells, and CX3CL1 may prevent fibrosis by affecting the apoptosis of monocytes. Conclusions Chemokines are requisites for mobilising, directing and positioning the effector cells in immune‐mediated liver disease. They are feasible therapeutic targets in autoimmune hepatitis, and the evaluation of monoclonal antibodies that neutralise the pro‐inflammatory ligands or designer peptides that block receptor activity are investigational opportunities.

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“…Interestingly, recent studies have shown that hepatitis B virus X protein (HBx) is a main factor in the development of HBV-induced disease. HBx increases endoplasmic reticulum (ER) stress-dependent CXCL12 expression and mediates HBV-induced recruitment of immune cells into the liver via CXCL12 signaling ( Cho et al, 2014 ). Furthermore, HBx is involved in the occurrence and development of HBV-related HCC through the CXCL12/CXCR4/β-catenin signaling axis ( Wang C. et al, 2017 ).…”

Section: The Regulatory Role Of Cxcr4 and Its Ligand In Hepatitismentioning

confidence: 99%

Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver Disease

Wang

Gao

et al. 2021

Front. Cell Dev. Biol.

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Chemokine receptors are members of the G protein-coupled receptor superfamily, which together with chemokine ligands form chemokine networks to regulate various cellular functions, immune and physiological processes. These receptors are closely related to cell movement and thus play a vital role in several physiological and pathological processes that require regulation of cell migration. CXCR4, one of the most intensively studied chemokine receptors, is involved in many functions in addition to immune cells recruitment and plays a pivotal role in the pathogenesis of liver disease. Aberrant CXCR4 expression pattern is related to the migration and movement of liver specific cells in liver disease through its cross-talk with a variety of significant cell signaling pathways. An in-depth understanding of CXCR4-mediated signaling pathway and its role in liver disease is critical to identifying potential therapeutic strategies. Current therapeutic strategies for liver disease mainly focus on regulating the key functions of specific cells in the liver, in which the CXCR4 pathway plays a crucial role. Multiple challenges remain to be overcome in order to more effectively target CXCR4 pathway and identify novel combination therapies with existing strategies. This review emphasizes the role of CXCR4 and its important cell signaling pathways in the pathogenesis of liver disease and summarizes the targeted therapeutic studies conducted to date.

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Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF‐1

Cited by 12 publications

References 32 publications

Hepatitis B Virus X Protein and Hepatocarcinogenesis

Hepatitis B Virus X Protein and Hepatocarcinogenesis

Review article: chemokines as orchestrators of autoimmune hepatitis and potential therapeutic targets

Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver Disease

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