Hepatitis B virus X protein promotes proliferation of hepatocellular carcinoma cells by upregulating miR-181b by targeting ING5

Xie, Xuhua; Xu, Xiaopei; Sun, Cuiyun; Yu, Zujiang

doi:10.1515/hsz-2018-0178

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…20 As an important co-factor of p53, the ING tumor suppressor family regulates DNA repair, apoptosis and cell cycle. 21 - 23 All ING proteins include plant homologous domains (PHD), which have been identified as binding motifs of DNA, RNA and proteins that bind histones in a methylated sensitive manner to regulate chromatin structure. 7 , 24 , 25 Thus they are closely related to the pathogenesis of different types of cancer as well as tumor growth (angiogenesis) and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma

Jiang

Wang

Mou

et al. 2021

Technol Cancer Res Treat

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Aims: Lysine acetyltransferase 6B (KAT6B), is a histone acetyltransferase implicated to have a role in tumor suppression. However, the relationship between KAT6B and hepatocellular carcinoma (HCC) is unclear. The purpose of this study was to detect the expression of KAT6B in HCC tissues and analyze its connection with the clinicopathological features of HCC. Methods: First, we performed immunohistochemical staining on 250 HCC tissues and 222 non-tumor liver tissues to examine the expression of KAT6B.Then the relation between KAT6B expression and clinicopathological parameters was analyzed by chi-square test, and the overall survival analysis was conducted by Kaplan-Meier survival method. In addition, based on the Oncomine expression array online and the UALCAN database, we compared KAT6B expression differences between normal liver tissues and HCC tissues more broadly. Results: Compared with normal tissues, KAT6B expression was significantly lower in HCC tissues. Low KAT6B expression was found to be related to gender, AFP level, and tumor size. According to the online database, KAT6B expression was found to be decreased in HCC tissues and high in normal tissues. Conclusions: Lower expression of KAT6B is associated with poor prognosis of HCC, and KAT6B may be a potential tumor suppressor in liver cancer.

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Section: Discussionmentioning

confidence: 99%

Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma

Jiang

Wang

Mou

et al. 2021

Technol Cancer Res Treat

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“…miR-331-3p could promote proliferation of HCC cells by targeting ING5, which was strengthened by hepatitis B virus (HBV) ( Cao et al, 2015 ). HBx protein of HBV accelerated the proliferation of HCC cells by up-regulating miR-181b to target ING5 ( Xie et al, 2018 ). In neuroblastoma cells, ING5 is a negatively- regulated target gene of miR-376c-3p ( Zhang et al, 2019 ), and SAHA down-regulates miR-196-b and miR-543 expression to facilitate the translation of ING5 protein ( Wu et al, 2018 ).…”

Section: The Regulation Of Ing5 Expressionmentioning

confidence: 99%

The roles of ING5 in cancer: A tumor suppressor

Zheng

Xue²,

Jiang³

2022

Front. Cell Dev. Biol.

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As a Class II tumor suppressor, ING5 contains nuclear localization signal, plant homeodomain, novel conserved region, and leucine zipper-like domains. ING5 proteins form homodimer into a coil-coil structure, and heterodimers with ING4, histone H3K4me3, histone acetyltransferase (HAT) complex, Tip60, Cyclin A1/CDK2, INCA1 and EBNA3C for the transcription of target genes. The acetylated proteins up-regulated by ING5 are preferentially located in nucleus and act as transcription cofactors, chromatin and DNA binding functions, while those down-regulated by ING5 mostly in cytoplasm and contribute to metabolism. ING5 promotes the autoacetylation of HAT p300, p53, histone H3 and H4 for the transcription of downstream genes (Bax, GADD45, p21, p27 and so forth). Transcriptionally, YY1 and SRF up-regulate ING5 mRNA expression by the interaction of YY1-SRF-p53-ING5 complex with ING5 promoter. Translationally, ING5 is targeted by miR-196, miR-196a, miR-196b-5p, miR-193a-3p, miR-27-3p, miR-200b/200a/429, miR-1307, miR-193, miR-222, miR-331-3p, miR-181b, miR-543 and miR-196-b. ING5 suppresses proliferation, migration, invasion and tumor growth of various cancer cells via the suppression of EGFR/PI3K/Akt, IL-6/STAT3, Akt/NF-κB/NF-κB/MMP-9 or IL-6/CXCL12 pathway. ING5-mediated chemoresistance is closely linked to anti-apoptosis, overexpression of chemoresistant genes, the activation of PI3K/Akt/NF-κB and Wnt/β-catenin signal pathways. Histologically, ING5 abrogation in gastric stem-like and pdx1-positive cells causes gastric dysplasia and cancer, and conditional ING5 knockout in pdx1-positive and gastric chief cells increases MNU-induced gastric carcinogenesis. Intestinal ING5 deletion increases AOM/DSS- induced colorectal carcinogenesis and decreases high-fat-diet weight. The overexpression and nucleocytoplasmic translocation of ING5 are seen during carcinogenesis, and ING5 expression was inversely associated with aggressive behaviors and poor prognosis in a variety of cancers. These findings indicated that ING5 might be used for a molecular marker for carcinogenesis and following progression, and as a target for gene therapy if its chemoresistant function might be ameliorated.

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“…Various miRNAs are involved such as miR-196a in pancreatic cancer (140), miR-1307 in ovarian cancer (32), miR-24 in breast cancer (141) and miR-27-3p in osteosarcoma (142). In addition, two reports have shown that miR-331-3p and miR-181b both of which target the 3'UTR of ING5 are upregulated by the hepatitis B virus protein X (143,144). This overexpression can promote the proliferation of hepatocarcinoma cancer cells.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Regulat-INGs in tumors and diseases: Focus on ncRNAs

et al. 2019

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ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvement of non-coding RNAs (ncRNAs) and in particular microRNAs (miRNAs) in post-transcriptional gene regulation is well established. miRNAs are short sequences (18 to 25 nucleotides) that can bind to the 3 'UTR sequence of the targeted messenger RNA (mRNA), leading to its degradation or translational repression. Interactions between the ING family and miRNAs have been described in some cancers but also in other diseases. The involvement of miRNAs in ING family regulation opens up new fields of investigation, particularly for targeted therapies. In this review, we will summarize the regulatory mechanisms at the RNA and protein level of the ING family and focus on the interactions with ncRNAs.

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Hepatitis B virus X protein promotes proliferation of hepatocellular carcinoma cells by upregulating miR-181b by targeting ING5

Cited by 11 publications

References 27 publications

Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma

Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma

The roles of ING5 in cancer: A tumor suppressor

Regulat-INGs in tumors and diseases: Focus on ncRNAs

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