Hepatitis B virus X protein–induced SH2 domain–containing 5 (SH2D5) expression promotes hepatoma cell growth via an SH2D5–transketolase interaction

Yang, Zheng; Ming, Pingpo; Zhu, Chengliang; Yu, Shaohua; Xu, Shilei; Chen, Aidong; Wang, Jun; Zhang, Binghong

doi:10.1074/jbc.ra118.005739

Cited by 18 publications

(12 citation statements)

References 35 publications

(43 reference statements)

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“…The mechanism underlying the carcinogenic roles of TKT in tumors has been investigated in a number of studies. A recent study has reported that TKT interacts with SH2 domain-containing 5 and activates STAT3 phosphorylation, thus promoting the proliferation of liver cancer cells (34). This result suggested that STAT3 may be involved in the regulation of liver cancer cell proliferation by TKT.…”

Section: Discussionmentioning

confidence: 99%

Prognostic values of transketolase family genes in ovarian cancer

2019

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Transketolase genes are key rate-limiting enzymes in the non-oxidative part of the pentose phosphate pathway, which is an important metabolic pathway in ribose-5-phosphate production. Three human transketolase genes have been identified: Transketolase (TKT), transketolase-like gene 1 (TKTL1) and transketolase-like gene 2 (TKTL2). Transketolase genes serve crucial roles in the tumorigenesis, metastasis and outcome of multiple types of cancer. However, the expression levels and prognostic values of transketolase family genes in patients with ovarian cancer remain unclear. The purpose of the study was to analyze the expression level and prognostic significance of transketolase family genes in ovarian cancer. In the present study, the mRNA expression levels of three transketolase genes in ovarian cancer and normal ovarian tissue were compared by Oncomine. The prognostic values of these genes were systemically assessed using the Kaplan-Meier plotter database. In addition, the associations between the mRNA levels of these transketolase genes and the clinicopathological characteristics of patients with ovarian cancer, such as histological subtype, clinical stage, grade, tumor protein p53 (TP53) mutation status and chemotherapy history were studied. The prognostic roles of transketolase genes were also evaluated in a validation dataset. The results demonstrated that TKT and TKTL1 expression in ovarian cancer tissues was elevated compared with that in normal ovarian tissues. In addition, high mRNA expression of the three transketolase genes was identified to be associated with poorer progression-free survival (PFS) in patients with serous ovarian cancer, especially in patients at an advanced stage. TKTL2 was significantly associated with poor overall survival in all patients with ovarian cancer. Additionally, transketolase family genes served a role in predicting PFS in patients with ovarian cancer treated with platinum and/or taxol. High expression of the three transketolase genes was associated with unfavorable PFS in patients with TP53-mutated ovarian cancer, but not in patients with TP53 wild-type ovarian cancer. These results suggested that transketolase family genes may serve important roles in the prognosis of patients with ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Prognostic values of transketolase family genes in ovarian cancer

2019

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“…SH2 domain containing protein 5, or SH2D5, is a transcriptional target of YAP/TAZ ( 158 ) and promotes tumor growth through interaction with transketolase, a regulator of the STAT3 signaling pathway ( 309 ). The STAT3 signaling pathway is essential during physiological and tumor angiogenesis ( 310 ).…”

Section: Downstream Effectors Of Yap/taz In Tumor Angiogenesismentioning

confidence: 99%

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

et al. 2021

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Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature. The tumor vessels promote tumor metastasis and complicate delivery of anti-cancer therapies. In many types of tumors, YAP/TAZ activation is correlated with increased levels of angiogenesis. In addition, endothelial YAP/TAZ activation is important for the formation of new blood and lymphatic vessels during development. Oncogenic activation of YAP/TAZ in tumor cell growth and invasion has been studied in great detail, however the role of YAP/TAZ within the tumor endothelium remains insufficiently understood, which complicates therapeutic strategies aimed at targeting YAP/TAZ in cancer. Here, we overview the upstream signals from the tumor microenvironment that control endothelial YAP/TAZ activation and explore the role of their downstream targets in driving tumor angiogenesis. We further discuss the potential for anti-cancer treatments and vascular normalization strategies to improve tumor therapies.

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“…Six genes (SH2D5, KIAA0825, LSAMP, KLHL29, PHLDB1 and KNTC1) were not annotated in any known GO term and KEGG functional classification. Most genes, such as KNTC1 (Liu et al, ), PHLDB1 (Baskin et al, ) and SH2D5 (Zheng et al, ), are involved in the development of various tumour cells, neural behaviour (like LSAMP) (Singh et al, ) and sensory ability defects (Schilit et al, ). However, KLHL29 has known functions in the protein degradation process through the ubiquitination pathway, and this gene was also identified as having a heat stress association in catfish (Jin et al, ; Liu et al, ).…”

Section: Resultsmentioning

confidence: 99%

Whole‐genome analysis identifying candidate genes of altitude adaptive ecological thresholds in yak populations

Basang

Zhu

2019

J Animal Breeding Genetics

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The domestic yak (Bos grunniens) is an iconic symbol of animal husbandry on the Qinghai-Tibet Plateau. Long-term domestication and natural selection have led to a wide distribution of yak, forming many ecological populations to adapt to the local ecological environment. High altitude is closely related to oxygen density, and it is an important environmental ecological factor for biological survival and livestock production. The aim of the present study was to perform a preliminary analysis to identify the candidate genes of altitude distribution adapted ecological thresholds in yak using next-generation sequence technology. A total of 15,762,829 SNPs were obtained from 29 yaks with high-and low-altitude distribution by genome-wide sequencing. According to the results of the selective sweep analysis with FST and ZHp, 21 candidate genes were identified. 14 genes (serine/threonine protein kinase TNNI3K, TEN1, DYM, ITPR1, ZC4H2, KNTC1, ADGRB3, CLYBL, TANGO6, ASCC3, KLHL3, PDE4D, DEPDC1B and AGBL4) were grouped into 32 Gene Ontology terms, and four genes (RPS6KA6, ITPR1, GNAO1 and PDE4D) annotated in 35 pathways, including seven environmental information processing and one environmental adaptation. Therefore, the novel candidate genes found in the current study do not only support new theories about high-altitude adaptation, but also further explain the molecular mechanisms of altitude adaptation threshold in yaks. K E Y W O R D Saltitude adaption, ecological threshold, selection signatures, yak 372 | E Et al.

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Hepatitis B virus X protein–induced SH2 domain–containing 5 (SH2D5) expression promotes hepatoma cell growth via an SH2D5–transketolase interaction

Cited by 18 publications

References 35 publications

Prognostic values of transketolase family genes in ovarian cancer

Prognostic values of transketolase family genes in ovarian cancer

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

Whole‐genome analysis identifying candidate genes of altitude adaptive ecological thresholds in yak populations

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