Hepatitis C: A Review

Yoho, Robert; Cruz, Leonard L.; Mazaheri, Reza; Cruz, Andrea T.

doi:10.1097/01.prs.0000070701.04809.95

Cited by 7 publications

(2 citation statements)

References 54 publications

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“…A p roximadamente 34% dos pacientes se queixaram de parestesias, principalmente nos membros superiores. A ENMG diagnosticou mononeuropatia múltipla em 11 (14,1%, IC95% 7,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)2) pacientes e síndro m e do túnel do carpo em 4 (5,1%). Conclusão: C o m p rometimento dos nervos periféricos é comum em pacientes com VHC, sendo neuropatia múltipla a apresentação mais comumente diagnosticada pela ENMG.…”

Section: Resumo -I N T Roduçãounclassified

Peripheral neuropathy in patients with hepatitis virus C infection in the Amazon region

Gomes

Nora

Marquezini

et al. 2006

Arq. Neuro-Psiquiatr.

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-Introduction: Hepatitis virus C (HCV) infection is considered a health problem in the State of A c re localized in the Brazilian Amazon which has a prevalence rate of 5.9%. Peripheral neuropathy is a common extra-hepatic manifestation in patients with HCV. Objective: To determine the prevalence of peripheral neuropathies using clinical and neurophysiological parameters. Method: A cross sectional study was perf o rmed in patients assisted by a specialized center of infectious diseases in the State of Acre . All patients completed a clinicoepidemiological questionnaire, physical examination and nerve conduction studies (NCS). Results: We studied 78 patients with mean age 45.5 years (range from 10 to 76 years), two thirds were male, 51% had at least 8 years of formal education and 96% lived in the capital city of A c re State. Roughly 34% of patients complained about paresthesias mainly in upper limbs. The NCS diagnosed multiple mononeuropathy in 11 (14.1%; IC95% 7.6-23.2) patients and carpal tunnel syndrome in 4 (5.1%) patients. Conclusion: Subclinical involvement of peripheral nerves seems common in patients with H C V, with multiple mononeuropathy the main manifestation of nerve injury in this region as suggested by electrophysiological studies.KEY WORDS: hepatitis virus C, HCV, peripheral neuro p a t h y, nerve conduction studies, Amazon re g i o n , prevalence. N e u ropatia periférica em pacientes com infecção pelo vírus C da hepatite na região amazônica RESUMO -I n t rodução:A infecção pelo vírus da hepatite C (VHC) é considerada um problema de saúde pública no Estado do Acre com uma prevalência de 5,9%. Neuropatia periférica é uma manifestação extrahepática comum em pacientes com VHC. Objetivo: Determinar a prevalência de neuropatias periféricas através de parâmetros clínicos e neuro f i s i o l ó g i c o s . Método: Foi realizado estudo transversal em pacientes atendidos em uma clínica especializada de doenças infecciosas do Estado do Acre. Todos os pacientes foram submetidos a um questionário clínico-epidemiológico, exame físico e eletro n e u romiografia (ENMG). Resultados: Foram estudados 78 pacientes, com idade média de 45,5 anos (10 a 76), dois terços eram do sexo masculino, 51% tinha pelo menos 8 anos de educação formal e 95% moravam na capital do Estado. A p roximadamente 34% dos pacientes se queixaram de parestesias, principalmente nos membros superiores. A ENMG diagnosticou mononeuropatia múltipla em 11 (14,1%, IC95% 7,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)2) pacientes e síndro m e do túnel do carpo em 4 (5,1%). Conclusão: C o m p rometimento dos nervos periféricos é comum em pacientes com VHC, sendo neuropatia múltipla a apresentação mais comumente diagnosticada pela ENMG.

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Section: Resumo -I N T Roduçãounclassified

Peripheral neuropathy in patients with hepatitis virus C infection in the Amazon region

Gomes

Nora

Marquezini

et al. 2006

Arq. Neuro-Psiquiatr.

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“…Risk of plastic surgeons’ exposure to hepatitis C has been previously discussed in the plastic surgery literature, albeit in the early 2000s. 1 However, in the 15 years since this topic was last visited in plastic surgery, the escalation of the opioid crisis in the United States has led to important contextual changes.…”

Section: Introductionmentioning

confidence: 99%

Assessing State Variation in Plastic Surgeons’ Risk of Hepatitis C Exposure: Revisit in Methodology

Hardy

Mullens

Mason

2020

Plastic and Reconstructive Surgery - Global Open

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Background: As the national opioid epidemic escalates, rates of the Hepatitis C (HCV) infection have similarly risen. Surgeons exposed intraoperatively secondary to sharp instrument or needle-sticks are affected both socioeconomically and physically. Current treatment strategies involve antiretroviral agents that have not been universally available. This study evaluates the current risk of surgeon exposure to HCV. Methods: CDC data regarding state-by-state HCV diagnosis reporting were combined with the plastic surgery workforce data from the ASPS. Proxy variables for exposure risk to HCV were generated for each state and compared. Results: West Virginia plastic surgeons were found to have a significantly elevated risk of exposure (60.0 versus 18.7, P < 0.0001). Their exposure risk is a notable outlier compared with the rest of the country (Risk >3 × IQR + 75th percentile). Similarly, states within the Ohio Valley were found to be at increased risk (34.8 versus 16.0, P = 0.05). States most heavily burdened by the opioid crisis were found to be at an increased risk for HCV exposure (40.8 versus 13.6, P = 0.0003). Conclusions: Plastic surgeons employed in states within the Ohio Valley were found to be at an increased risk of exposure to HCV. Plastic surgeons operating in states severely impacted by the opioid crisis were found to be at an increased risk of exposure. These findings underscore the importance of reducing the risk in the operating room and the need for better data collection to better understand this association and mitigate the risk to the operating surgeon.

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