Hepatitis C among child transfusion and adult renal dialysis patients in Indonesia.

Chanpong, G Fraser; Laras, Kanti; Sulaiman, H. Ali; Soeprapto, Widodo; Purnamawati, Sinta; Sukri, Nono; Sie, Annie; Tan, Ratna; Campbell, James; Corwin, Andrew L.

doi:10.4269/ajtmh.2002.66.317

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…Although blood transfusion has been pointed out as an important risk factor for viral hepatitis within hemodialysis population (Covic et al 1999, Chanpong et al 2002, Hinrichsen et al 2002, in the present investigation this factor was not associated with HBV and HCV infections. Therefore, probably the screening of blood products for HBsAg, anti-HBc and anti-HCV in Brazilian blood banks, and the use of erythropoietin for anemia treatment should have contributed to reduce this risk among our hemodialysis patients.…”

Section: Discussionsupporting

confidence: 41%

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[No Title Available]

Souza

Luz²,

Teles

et al. 2003

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 41%

“…Recent data from Indonesia, Syria, and Jordan revealed rates of 63.4%, 48.9% and 34.6%, respectively (Othman & Monem 2001, Bdour 2002, Chanpong et al 2002. In Brazil, anti-HCV prevalence ranges from 20.3% to 64.7% (Vanderborght et al 1995, Carneiro et al 2001, Santana et al 2001, Busek et al 2002.…”

Section: Discussionmentioning

confidence: 99%

[No Title Available]

Souza

Luz²,

Teles

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…However, the prevalence was lower than that in children with hematological diseases (39%) [41] and in hemophilia patients (56.9%) [42]. The anti-HCV antibody-positive rate was significantly higher among the IDUs; however, 28.8% of the anti-HCV antibody-positive samples were derived from the nonIDUs.…”

Section: Discussionmentioning

confidence: 66%

Molecular epidemiology of HIV, HBV, HCV, and HTLV-1/2 in drug abuser inmates in central Javan prisons, Indonesia

Prasetyo

Dirgahayu

Sari

et al. 2013

J Infect Dev Ctries

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Introduction: This study was conducted to determine the current molecular prevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and human T lymphotropic virus-1/2 (HTLV-1/2) circulating among drug abuser inmates incarcerated in prisons located in Central Java, Indonesia. Methodology: Socio-epidemiological data and blood specimens were collected from 375 drug abuser inmates in four prisons. The blood samples were analyzed with serological and molecular testing for HIV, HBV, HCV, HDV, and HTLV-1/2. Results: The seroprevalence of HIV, HBsAg, HCV, HDV, and HTLV-1/2 in drug abuser inmates was 4.8% (18/375), 3.2% (12/375), 34.1% (128/375), 0% (0/375), and 3.7% (14/375), respectively. No co-infections of HIV and HBV were found. Co-infections of HIV/HCV, HIV/HTLV-1/2, HBV/HCV, HBV/HTLV-1/2, and HCV/HTLV-1/2 were prevalent at rates of 4% (15/375), 1.3% (5/375), 1.1% (4/375), 0.3% (1/375), and 2.1% (8/375), respectively. The HIV/HCV co-infection rate was significantly higher in injection drug users (IDUs) compared to non-IDUs. Triple co-infection of HIV/HCV/HTLV-1/2 was found only in three IDUs (0.8%). HIV CRF01_AE was found to be circulating in the inmates. HBV genotype B3 predominated, followed by C1. Subtypes adw and adr were found. HCV genotype 1a predominated among HCV-infected inmates, followed by 1c, 3k, 3a, 4a, and 1b. All HTLV-1 isolates shared 100% homology with HTLV-1 isolated in Japan, while all of the HTLV-2 isolates were subtype 2a. Conclusion: Drug abuser inmates in prisons may offer a unique community to bridge prevention and control of human blood-borne virus infection to the general community.

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“…[13][14] Patient's age and the number of transfused blood products are the 2 factors most consistently associated with increased prevalence of HBV and HCV infection in dialysis patients, irrespective of geographic location. 16 In this study the prevalence of HBV and HCV was significantly higher in patients those who received more than 5 blood transfusions than those who received less than 5 blood transfusions. Chanpong et al, and Hinrichson et al, noted that higher rate of seropositivity is found in patients with multiple transfusions.…”

Section: Discussionmentioning

confidence: 51%

“…Chanpong et al, and Hinrichson et al, noted that higher rate of seropositivity is found in patients with multiple transfusions. [16][17] As these viral infections have common modes of transmission, presence of co-infection in patients is not rare and is relatively high in transfusion recipients. The prevalence of dual infection of HCV and HBV ranges from 3-3.7% in India.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis B and hepatitis C in patients of chronic kidney disease

Sehgal¹,

Singh

et al. 2019

Int J Res Med Sci

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Background: Patients of CKD are highly exposed to HBV and HCV because of multiple blood transfusions and exposure to contaminated equipments. Infections by HBV and HCV are significant cause of morbidity in CKD patients by causing liver damage and membranoproliferative GN. Present study was done to observe the prevalence of HBV and HCV in patients of CKD and to compare the prevalence of these infections in patients who were on maintenance haemodialysis and who were not on maintenance hemodialysis.Methods: This study had been conducted on 140 patients. Patients were diagnosed as having CKD on basis of Cockcroft-gault equation as per KDOQI guidelines. Stage 3, 4 or 5 patients were included for the study whereas patients with stage 1 or 2 were excluded. These 140 cases were divided into 2 groups, Group I included 70 cases who were on maintenance hemodialysis and Group II included 70 patients who were not on maintenance hemodialysis. The prevalence of HBV and HCV in the two groups was observed. Diagnosis of HBV was made by detection of HBsAg (one step immunoassay) and diagnosis of HCV was made by detection of antibodies to Hepatitis C(enzyme linked immunoassay). Prevalence data of NCDC was used for comparison with general population.Results: In Group I, 15 (21%) patients were positive for HCV and 9 (12.9%) were positive for HBV which is significantly higher compared to Group II patients in which 6 (8.6%) and 2 (2.9%) were positive respectively. Overall out of 140 patients,21(15%) were positive for HCV and 11(7.9%) were positive for HBV, which is significantly higher compared to data of NCDC for general population in which prevalence of HCV and HBV is 1% and 4% respectivelyConclusions: Prevalence of HBV and HCV was significantly higher in patients of CKD than the general population, which was further higher in patients who were on maintenance hemodialysis and have received multiple blood transfusions, emphasizing the need to implement the methods to limit the spread of HBV and HCV.

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Hepatitis C among child transfusion and adult renal dialysis patients in Indonesia.

Cited by 6 publications

References 22 publications

[No Title Available]

[No Title Available]

Molecular epidemiology of HIV, HBV, HCV, and HTLV-1/2 in drug abuser inmates in central Javan prisons, Indonesia

Prevalence of hepatitis B and hepatitis C in patients of chronic kidney disease

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