Hepatitis C in the setting of HIV co-infection

Khalili, Mandana; Behm, Brian W.

doi:10.1016/s1286-4579(02)01652-0

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…Due to shared transmission routes, co-infection with HCV and HIV-1 has become common among individuals who had high risks of blood exposures. According to the data from a large European cohort, the co-infection accounted for 85% of the hemophiliacs cases [Khalili and Behm, 2002]. Among IDUs who were positive for anti-HIV-1, the anti-HCV prevalence can be as high as 90% [Thomas et al, 1996;CDC, 1999].…”

Section: Introductionmentioning

confidence: 99%

“…HIV-1 can accelerate the progression of HCV-related liver disease [Beld et al, 1998;Martinez-Sierra et al, 2003;Lichterfeld et al, 2005]. Although the effect of HCV on HIV-1 infection is controversial, most studies showed an increase in mortality due to liver disease [Khalili and Behm, 2002]. HCV may act as a direct cofactor to hasten the progression of AIDS [Beld et al, 1998;Carlos et al, 2004].…”

Section: Introductionmentioning

confidence: 99%

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The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co‐infected with HIV‐1 in Yunnan, China

Xia

Lü

Tee

et al. 2008

Journal of Medical Virology

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The Yunnan province is the epicenter of HIV-1 epidemics in China and a center for drug trafficking to the other parts of the world. In six prefectures of this province, a total of 132 IDUs were recruited to determine the seroprevalence of HCV and HIV-1 and the positive rates were 93.94% and 68.18%, respectively (P <0.001). Co-infection with HCV and HIV-1 was found among 89 IDUs, of whom several HCV fragments were amplified and sequenced. Sequences of the HCV 5′NCR-C and NS5B region were determined from 82 IDUs. Phylogenetic analyses showed consistent genotyping among 80 IDUs. Among them HCV genotypes 1a, 1b, 3a, 3b, 6a, 6n, and a tentatively assigned novel 6u subtype were found in 1 (1.25%), 16 (20%), 19 (23.75%), 24 (30%), 4 (5%), 9 (11.25%) and 7 (8.75%) individuals, respectively. In two IDUs, genotyping results were discordant, suggesting mixed HCV infections or recombination. The proportion of patients with HCV 1b tended to decrease from the north to south and from the east to west in this province. Genotype 3 and 6 strains were more frequent in the southern prefectures. The novel subtype 6u strains were only detected in Dehong which borders Myanmar. Our findings showed a unique pattern of HCV genotype distribution, which is similar to that in the southeastern Asian countries but distinct from that among the general population in China. Routes of drug trafficking and the resulting high prevalence of HIV-1 infection may have contributed to this pattern of HCV genotype distribution.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co‐infected with HIV‐1 in Yunnan, China

Xia

Lü

Tee

et al. 2008

Journal of Medical Virology

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“…Treatment of both HIV and HCV is more complex in co-infected patients because of liver toxicity and drug interactions. [Bonacini and Puoti, 2000;Khalili and Behm, 2002;Mohsen et al, 2002;Thomas, 2002;Gonzalez and Talal, 2003;Sterling et al, 2003;Sulkowski and Thomas, 2003;Rockstroh and Spengler, 2004;Winnock et al, 2004].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus seropositivity in a South African Cohort of HIV co‐infected, ARV naïve patients is associated with renal insufficiency and increased mortality

Parboosing

Paruk

Lalloo

2008

Journal of Medical Virology

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HIV is known to affect the epidemiology, transmission, pathogenesis and natural history of HCV infection whilst studies on the effects of HCV on HIV have shown conflicting results and are confounded by the influence of intravenous drug use and antiretroviral therapy. This study was conducted in KwaZulu-Natal Province in South Africa where HIV is predominantly a sexually transmitted infection. Intravenous drug use is rare in this region and the study population was naïve to antiretroviral therapy. For this study, specimens from selected sentinel sites submitted to a central laboratory for routine HIV testing were screened for anti-HCV IgG antibodies. HIV positive HCV-positive patients were compared to HIV-positive HCV-negative patients in a subgroup of patients within this cohort in order to determine if HCV sero-prevalence was associated with clinical outcomes in a linked anonymous retrospective chart survey. The prevalence of HCV was 6.4% and that of HIV, 40.2% (n = 1,937). There was a significantly higher prevalence of HCV among HIV infected patients as compared to HIV negative patients (13.4% vs. 1.73% respectively) (n = 1,937, P < 0.001). HCV-HIV co-infected patients had significantly increased mortality (8.3 vs. 21%) (n = 162, P < 0.02). A significant association was found between HCV serostatus and abnormal urea levels (15.4 vs. 7.3 mmol/L, n = 134, P < 0.001) and creatinine levels (252.2 vs. 144.4 micromol/L, n = 134, P < 0.01). This study has found that hepatitis C co-infection is more common in HIV positive individuals and is associated with an increased mortality and renal morbidity.

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“…This may be explained by the fact that patients recently infected with HCV have usually a better response to treatment than those infected earlier. 8 Although female gender is usually associated with a better virologic response to antiviral therapy, 18,19 in our cohort, liver biopsy was performed less in women than in men. This result is consistent with other reports showing that women are less likely than men to undergo invasive procedures for the treatment of other diseases.…”

Section: Discussionmentioning

confidence: 87%

Factors Associated with Liver Biopsy Performance in HCV-HIV Coinfected Injecting Drug Users With HCV Viremia: Results From a Five-Year Longitudinal Assessment

Rey¹,

Carrieri

Spire

et al. 2004

Journal of Urban Health: Bulletin of the New York Academy of Me

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Hepatitis C in the setting of HIV co-infection

Cited by 5 publications

References 27 publications

The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co‐infected with HIV‐1 in Yunnan, China

The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co‐infected with HIV‐1 in Yunnan, China

Hepatitis C virus seropositivity in a South African Cohort of HIV co‐infected, ARV naïve patients is associated with renal insufficiency and increased mortality

Factors Associated with Liver Biopsy Performance in HCV-HIV Coinfected Injecting Drug Users With HCV Viremia: Results From a Five-Year Longitudinal Assessment

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