Hepatitis C viraemia and liver disease in symptom-free individuals with anti-HCV

Alberti, Alfredo; Morsica, Giulia; Chemello, Liliana; Cavalletto, D.; Noventa, Franco; Pontisso, Patrizia; Ruol, A

doi:10.1016/0140-6736(92)92234-7

Cited by 384 publications

(141 citation statements)

References 7 publications

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“…8,12,13,16,17,[28][29][30] This discrepancy has been attributed to the intermittent viremia in patients with chronic HCV infection. The lack of relationship between HCV RNA levels and liver fibrosis in our study may be due to a single HCV RNA value.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Ceylan¹,

Yardimci²,

Fincancı³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study was to investigate the independent variables for the degree of liver fibrosis in patients with chronic hepatitis C virus (HCV) infection. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this cross-sectional retrospective study, the patients were divided in two groups as Group A (patients with fibrosis score 0-2) and Group B (patients with fibrosis score 3-4) and they were compared in terms of age, gender, body mass index, alcohol consumption, presence of diabetes, serum HCV RNA, alanine aminotransferase, gamma-glutamyl transferase, and aspartate aminotransferase, total bilirubin, albumin, globulin and alkaline phosphatase levels, prothrombin time, blood thrombocyte count, splenomegaly in ultrasonographic examination, HCV genotype and liver steatosis. R Re es su ul lt ts s: : Of 201 patients, 93 (46.3%) were males; the median age was 51 (range: 18-77) years. It was found that serum gamma-glutamyl transferase and aspartate aminotransferase levels, age, prothrombin time and the presence of splenomegaly were independent variables predictive of advanced liver fibrosis. Odds ratio and p values were 1.984 and 0.013 for gamma-glutamyl transferase, 1.633 and 0.018 for aspartate aminotransferase, 1.861 and 0.003 for age, 5.598 and 0.008 for splenomegaly and 0.541 and 0.007 for prothrombin time, respectively. C Co on nc cl lu us si io on n: : The results of this study suggested that advanced age, elevated serum gamma-glutamyl transferase and, aspartate aminotransferase levels, prolonged prothrombin time and the presence of splenomegaly are independent variables determining severe liver fibrosis. K Ke ey y W Wo or rd ds s: : Liver cirrhosis; hepacivirus Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı kronik hepatit C virüsü (HCV) enfeksiyonlu olgularda karaciğer fibrozunun derecesini belirleyen bağımsız değişkenleri araştırmaktı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu geriye dönük kesitsel çalışmada hastalar Grup A (fibroz skoru 0-2 olanlar) ve Grup B (fibroz skoru 3-4 olanlar) olarak iki gruba ayrıldı ve gruplar yaş, cinsiyet, beden kitle indeksi, alkol kullanımı, diyabet varlığı, serum HCV RNA, alanin aminotransferaz, gama-glutamil transferaz, aspartat aminotransferaz, total bilirubin, albumin, globulin ve alkalen fosfataz seviyeleri, protrombin zamanı, kan trombosit sayısı, ultrasonografide splenomegali varlığı, HCV genotip ve karaciğer yağlanması açısın-dan karşılaştırıldı. B Bu ul lg gu ul la ar r: : İkiyüz bir hastadan 93 (%46,3)'ü erkekti ve ortanca yaş 51 (alt ve üst sınırlar: 18-77 yıl) idi. Serum gama-glutamil transferaz ve aspartat aminotransferaz düzeyleri, yaş, protrombin zamanı ve splenomegalinin ileri karaciğer fibrozunu belirleyen bağımsız değişkenler olduğu bulundu. Odds oranı ve p değerleri gamaglutamil transferaz için 1,984 ve 0,013; aspartat aminotransferaz için 1,633 ve 0,018; yaş için 1,861 ve 0,003; splenomegali için 5,598 ve 0,008 ve protrombin zamanı için 0,541 ve 0,007 idi. S So on nu uç ...

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Section: Discussionmentioning

confidence: 99%

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Ceylan¹,

Yardimci²,

Fincancı³

et al. 2012

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

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“…However, it is notable that the patients with resolved infection (HCV-RNA-negative) were not included in this computation. Because these patients usually have a normal histologic pattern on liver biopsy, 15,16 the actual proportion of cirrhosis among the initially infected patients could be slightly lower. On the other hand, we excluded from the histologic evaluation 8 patients with clinical evidence of cirrhosis because of the presence of thrombocytopenia: this leads to an underestimate in the frequency of liver cirrhosis that, however, was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Age at infection affects the long-term outcome of transfusion-associated chronic hepatitis C

Minola

Prati

Suter

et al. 2002

Blood

132

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“…In this respect, these data corroborate and extend the existing literature regarding other chronic liver diseases, e.g., hepatitis C and normal ALT values. 17 An important question is the following: How does one identify subjects with clinically significant NAFLD in the absence of symptoms, signs, or abnormal ALT values? It is clearly both unreasonable and impractical to perform routine liver biopsies for this purpose.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Histologic Spectrum of Nonalcoholic Fatty Liver Disease Associated With Normal Alt Values

2003

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A retrospective study was performed to (1) characterize the clinical and histologic features of those with nonalcoholic fatty liver disease (NAFLD) and normal alanine aminotransferase (ALT) values, (2) compare the spectrum of NAFLD associated with normal versus elevated ALT levels, and (3) determine whether there were differences in the clinical or histologic spectrum of NAFLD between those with a low normal versus high normal ALT value. A total of 51 subjects with NAFLD and normal ALT were identified and compared with 50 consecutive subjects with NAFLD and elevated ALT. The major indications for liver biopsy in those with normal ALT were unexplained hepatomegaly (n ‫؍‬ 21) and evaluation as a potential donor for living donor liver transplantation (n ‫؍‬ 16). The 2 groups were comparable with respect to age, gender distribution, and ethnicity. Approximately 80% of cases in both groups had at least 1 feature of the metabolic syndrome, the major risk factor for NAFLD. The 2 groups were also comparable with respect to the grade of the individual histologic parameters of NAFLD. A total of 12 subjects with normal ALT levels had bridging fibrosis, whereas 6 had cirrhosis. Diabetes was the only factor independently associated with an increased risk of advanced fibrosis (bridging fibrosis or cirrhosis) by multivariate analysis (relative risk: 2.3, P < .01). The mean steatosis (1.6 vs. 2.16, P < .04) and perisinusoidal fibrosis scores (0.35 vs. 0.9, P < .049) were lower in those with low normal (<30 IU/L) ALT versus high normal ALT. However, the prevalence of advanced fibrosis was similar (5 of 15 vs. 13 of 36, respectively). In conclusion, (1) the entire histologic spectrum of NAFLD can be seen in individuals with normal ALT values, (2) the histologic spectrum in these individuals is not significantly different from those with elevated ALT levels, and (3) a low normal ALT value does not guarantee freedom from underlying steatohepatitis with advanced fibrosis.

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Hepatitis C viraemia and liver disease in symptom-free individuals with anti-HCV

Cited by 384 publications

References 7 publications

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Predictors of Liver Fibrosis in Patients with Chronic HCV Infection

Age at infection affects the long-term outcome of transfusion-associated chronic hepatitis C

Clinical and Histologic Spectrum of Nonalcoholic Fatty Liver Disease Associated With Normal Alt Values

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