Hepatitis C virus and human immunodeficiency virus coinfection in Spain

Roca, Bernardino; Suárez, Ignacio; González, Juan; Garrido, Myriam; Fuente, Belén de la; Teira, Ramón; Geijo, Paloma; Cosín, Jaime; Pérez-Cortés, Salvador; Galindo, Marı́a José; Lozano, Fernando; Domingo, Peré; Viciana, Pompeyo; Ribera, Esteban; Vergara, Antonio; Sánchez, Trinitario

doi:10.1016/s0163-4453(03)00067-7

Cited by 37 publications

(34 citation statements)

References 26 publications

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“…Many of the 200 million individuals infected with hepatitis C (HCV) and the 50 million individuals infected with HIV are co-infected with both viruses [5][6][7][8][9]. As well as shared routes of transmission, there are many interactions between these small RNA viruses in which infection is often characterised by parenteral transmission followed by a seroconversion illness and then a long latent period lasting many years.…”

Section: Introductionmentioning

confidence: 99%

Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

et al. 2004

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There is increasing recognition of the potential morbidity and mortality associated with HIV-1 and hepatitis C (HCV) co-infection. HIV appears to adversely affect HCV disease while the reciprocal effect of HCV on HIV remains controversial. We therefore studied the effect of co-infection on dendritic cell function versus HIV infection alone, as previous work has shown that HCV impairs dendritic cell (DC) function. HIV-1 positive individuals with HCV were matched for CD4 count, HIV-1 RNA viral load and therapy, to HIV-1 positive patients without HCV. Monocyte-derived DC were generated and mixed leukocyte reactions were performed. We assessed allostimulatory capacity with and without administration of exogenous Th1 cytokines, using thymidine uptake and cell division analyses with the vital dye CFSE. We found that monocyte-derived DC from co-infected individuals showed no significant differences in allostimulatory capacity to ex vivo generated DC from HIV-1 infected individuals without HCV. Unlike the situation with HCV infection alone, this impairment was not reversed by increasing concentrations of either interleukin-2 or -12. Monocyte-derived DC from HIV-1 and HCV co-infected individuals have a similar allostimulatory capacity to DC from matched patients with HIV-1 alone. These findings are compatible with results of prior clinical studies that found no evidence that HCV co-infection altered HIV disease progression and has implications for immunotherapeutic approaches in co-infected individuals.

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Section: Introductionmentioning

confidence: 99%

Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

et al. 2004

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“…epatitis C virus (HCV) infection is one of the most common comorbid conditions in patients with human immunodeficiency virus (HIV) infection (25). Its prevalence is especially high in southern European countries, and its importance is highlighted by the fact that end-stage liver disease is an important cause of death in HCV/HIV-coinfected patients (2,25).…”

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confidence: 99%

Association of ITPA Gene Polymorphisms and the Risk of Ribavirin-Induced Anemia in HIV/Hepatitis C Virus (HCV)-Coinfected Patients Receiving HCV Combination Therapy

Domingo

Guardiola

Salazar

et al. 2012

Antimicrob Agents Chemother

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“…Resultados  En 253 pacientes (0,82 %) no está disponible la serología de la hepatitis C. Dada la alta asociación entre la infección por el virus de la hepatitis C y el factor de riesgo de infección por el VIH parenteral [55], a los 253 pacientes con este factor de riesgo se les considera en el presente estudio infectados por el virus de la hepatitis C, y a los pacientes sin ese factor de riesgo parenteral se les considera no infectados por el virus de la hepatitis C. …”

Section: Resultsunclassified

“…Se trata en la mayoría de casos de pacientes de mediana edad, entre los que predominan los hombres, el contagio del VIH por vía parenteral o sexual, y la alta prevalencia de coinfección por el virus de la hepatitis C [55]. Llama la atención en los pacientes de la Cohorte la alta prevalencia del tabaquismo, cercana al doble de la existente en la población general española adulta [60].…”

Section: Características Generales De Los Pacientes Del Estudiounclassified

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Factores relacionados con el insuficiente control de la infección por el VIH en la Cohorte Española VACH

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Hepatitis C virus and human immunodeficiency virus coinfection in Spain

Cited by 37 publications

References 26 publications

Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

Association of ITPA Gene Polymorphisms and the Risk of Ribavirin-Induced Anemia in HIV/Hepatitis C Virus (HCV)-Coinfected Patients Receiving HCV Combination Therapy

Factores relacionados con el insuficiente control de la infección por el VIH en la Cohorte Española VACH

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