Hepatitis C virus antibodies in a long-term follow-up of beta-thalassaemic children with acute and chronic non-A non-B hepatitis

Resti, Massimo; Azzari, Chiara; Rossi, Maria Elisabetta; Vullo, C; Zammarchi, Enrico; Vierucci, A

doi:10.1007/bf01957724

Cited by 38 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hence HCV was transmitted at high frequency to children under treatment for P-thalassemia. This finding is consistent with earlier results (10,11). The finding of increased transaminase levels in serum samples of patients 2 and 7 before the appearance of anti-HCV (Table 1) suggests that these HCV infections were antibody negative or that the liver damage in these cases was caused by something other than HCV.…”

Section: Resultssupporting

confidence: 92%

Pathogenesis of posttransfusion viral hepatitis in children with β-thalassemia

et al. 1994

View full text Add to dashboard Cite

The pathogenesis of posttransfusion hepatitis was determined in 14 children with beta-thalassemia. All had blood samples obtained in 1980 or 1981, were vaccinated against hepatitis B virus in 1983 and had another serum sample collected in 1989. Seven children had detectable antibodies against hepatitis C virus before vaccination, and all were positive in 1989. With specific solid-phase enzyme immunoassays, all children had antibodies against hepatitis B virus, X and polymerase antigens in 1981, and six had one or both antibodies in 1989. Hepatitis B virus infection was confirmed by means of polymerase chain reaction, which demonstrated virus DNA in 13 of the 14 children. The amplification products spanning the X/precore region were smaller than expected, suggesting mutations in this region. Cloning and sequencing of these products revealed deletions spanning part or all of the X gene. The results show that these children were infected with hepatitis B virus even without other markers in serum, that hepatitis B persists years after vaccination and that such infections are associated with the presence of X deletion mutants. Coinfection with hepatitis B and C viruses, the former containing a new class of variants, is common in children with beta-thalassemia.

show abstract

Section: Resultssupporting

confidence: 92%

Pathogenesis of posttransfusion viral hepatitis in children with β-thalassemia

et al. 1994

View full text Add to dashboard Cite

show abstract

“…Interestingly, although the It is also possible that underlying disease such as thalassemia and human immunodeficiency virus infection may have ag-majority of our pediatric patients had underlying diseases and/or complications and possessed various risk factors such gravated the hepatic lesion. 10,20,21 Taking into consideration the reports from Japan that patients with CHC in their 20s as drug-induced hepatic injury 9,23 and chronic passive congestion, few children had overt pathological changes reand 30s without complications usually do not develop cirrhoflecting these factors, and the severity of the eight characteristic lesions of CHC was also mild in the children. However, there were 4 children in stage 3.…”

Section: Methodsmentioning

confidence: 99%

Pathology of chronic hepatitis C in children

et al. 1997

View full text Add to dashboard Cite

Extensive studies on hepatitis C have been conducted since Limited information is available regarding the histology of the specific serological test for hepatitis C virus (HCV) infechepatitis C virus infection in children. The aim of this study tion was developed, and the characteristics of this disease was to determine the histological pattern of chronic hepatitis have been established. [1][2][3][4] Recent pathological studies have C (CHC) in children, and liver biopsy specimens from 109 clearly defined the histological characteristics of chronic heppediatric patients with CHC were examined. Each biopsy atitis C (CHC), e.g., lymphoid aggregates in the portal tract, specimen was evaluated based on a numerical scoring system bile duct damage, and large-droplet fatty changes, in comparfor the stage of fibrosis (1-4), the grade of portal/periportal ison to chronic hepatitis B (CHB). [5][6][7] However, in-depth studnecroinflammation (0-4), the grade of lobular necroinflammaies of CHC in children have not been conducted, and the tion (0-4), and their sum (final grade). The histological lesions histological characteristics of this disease in pediatric patients considered to be characteristic of chronic hepatitis were also remained to be identified, although it is well known that evaluated. None of the children had liver cirrhosis, and 105 even pediatric patients with CHB have various degrees of cases (97%) were stage 1 or 2. Only 4 children were stage 3.hepatic lesions ranging from mild fibrosis to liver cirrhosis. 8 Two of these 4 cases showed hemosiderosis. A significant Some studies have reported histopathology of CHC in pediatcorrelation was observed between the staging score and the ric patients, 9-13 but they examined only a small number of final grade in the pediatric patients (r Å .59; P õ .0001). The liver biopsy specimens, and their histological evaluation histological characteristics of adult CHC, such as lymphoid methods differed. For example, Inui et al. 9 examined the aggregate, bile duct injury, and fatty changes, were also obliver biopsy specimens of 25 pediatric patients with CHC served in the children. In conclusion, the majority of children who were all transfusion associated, but the investigators did with CHC presented with mild fibrosis, but a few showed not find liver cirrhosis. In contrast, Lai et al. 10 followed up CHC with lobular distortion and hemosiderosis. Frequent 46 thalassemic children who were treated with blood transfublood transfusion may aggravate hepatic lesions in pediatric sions and found that 5 patients (11%) developed liver cirrho-CHC. (HEPATOLOGY 1997;26:771-775.) sis during the following 8 years.The present study was designed to clarify the histological changes in the liver of pediatric patients with CHC. PATIENTS AND METHODSAbbreviations: HCV, hepatitis C virus; CHC, chronic hepatitis C; CHB, chronic hepatitis B.Patients. We collected 109 biopsy specimens from 109 pediatric men and 62 women who ranged in age from 23 to 95 years old Received September 27, 1996; accept...

show abstract

“…In fact, high morbidity has been observed in cases of severe immunosuppression (transplanted patients receiving organs from HCVseropositive donors) [22], in drug abusers [10] and in [3-thalassaemic patients exposed to iron overload [24].…”

Section: Discussionmentioning

confidence: 99%

“…However, the frequency of these sequelae, the rate of development and the clinical features in children with ALL remain to be defined since current data come largely from long-term survivors with CLD, rather than from prospectively followed patients [ 16,24].…”

Section: Introductionmentioning

confidence: 98%

Incidence and morbidity of infection by hepatitis C virus in children with acute lymphoblastic leukaemia

et al. 1994

View full text Add to dashboard Cite

A group of 90 patients with acute lymphoblastic leukaemia (ALL) in first continuous complete remission (CCR), admitted in our hospital between January 1986 and September 1992, were tested for the presence of antibodies against hepatitis C virus (HCV), antibodies against hepatitis B virus and antibodies against HIV-1 during maintenance therapy or thereafter. They were compared with a group of 71 children with other malignancies in first CCR who had been diagnosed consecutively from January 1986 to September 1992. No patient with ALL or any other malignancy was found to be positive for hepatitis B surface antigen or HIV-1. HCV-specific antibodies were detected in 28 out of 87 children (32.1%) with ALL and in 4 out of 44 patients (9%) with malignancies other than ALL who had received at least one transfusion of blood or platelets (P < 0.01). HCV-specific antibodies were also detected in one out of three untransfused children with ALL but in none of the untransfused children with malignancies other than ALL. HCV-specific seropositivity influenced the management of children with ALL during maintenance therapy. In fact, as a result of abnormal liver function tests, maintenance therapy had to be suspended significantly more often in the case of HCV-seropositive patients with ALL than in HCV-seronegative ones. Despite the high morbidity during maintenance therapy, chronic liver disease (CLD) was uncommon in both groups: five children with ALL (17.2% of HCV-seropositive children) and one child with a malignancy other than ALL (25%) had CLD.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Hepatitis C virus antibodies in a long-term follow-up of beta-thalassaemic children with acute and chronic non-A non-B hepatitis

Cited by 38 publications

References 29 publications

Pathogenesis of posttransfusion viral hepatitis in children with β-thalassemia

Pathogenesis of posttransfusion viral hepatitis in children with β-thalassemia

Pathology of chronic hepatitis C in children

Incidence and morbidity of infection by hepatitis C virus in children with acute lymphoblastic leukaemia

Contact Info

Product

Resources

About