Hepatitis C virus antibody in patients with primary liver cancer (hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma) in Japan

Tomimatsu, Masahiko; Ishiguro, Nozomu; Taniai, Makiko; Okuda, Hiroyuki; Saito, Akiko; Obata, Hiroshi; Yamamoto, Masakazu; Takasaki, Ken; Nakano, Masayuki

doi:10.1002/1097-0142(19930801)72:3<683::aid-cncr2820720310>3.0.co;2-c

Cited by 99 publications

(78 citation statements)

References 20 publications

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“…A US cohort of individuals found HBV nucleic acids in ICC. Furthermore, recent studies show that HBV has been suggested to be involved in the pathogenesis of ICC through the inflammatory process (Tomimatsu et al, 1993;Reeves and DeMatteo, 2000;Liu et al, 2003). These strongly support the notion that HBV can be associated with ICC even in the absence of cirrhosis (Perumal et al, 2006) and further support the potential role of HBV infection in the pathogenesis of biliary cancers.…”

Section: Discussionmentioning

confidence: 99%

The Metabolic Syndrome and Risk Factors for Biliary Tract Cancer: A Case-control Study in China

Wu¹,

He²,

Yu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objectives: Recent data show that the metabolic syndrome may play a role in several cancers, but the etiology for biliary tract cancer is incompletely defined. The present aim was to evaluate risk factors for biliary tract cancer in China. Methods: A case-control study in which cases were biliary tract cancer patients referred to Peking Union Medical College Hospital (PUMCH). Controls were randomly selected from an existing database of healthy individuals at the Health Screening Center of PUMCH. Data on the metabolic syndrome, liver diseases, family history, and history of diabetes and hypertension were collected by retrospective review of the patients' records and health examination reports or by interview. Results: A total of 281 patients (102 intrahepatic cholangiocarcinoma (ICC), 86 extrahepatic cholangiocarcinoma (ECC) and 93 gallbladder carcinoma (GC)) and 835 age-and sex-matched controls were enrolled. HBsAg + /anti-HBc + (P=0.002), history of diabetes (P=0.000), cholelithiasis (P=0.000), TC (P=0.003), and HDL (P=0.000) were significantly related to ICC. Cholelithiasis (P=0.000), Tri (P=0.001), LDL (P=0.000), diabetes (P=0.000), Apo A (P=0.000) and Apo B (P=0.012) were significantly associated with ECC. Diabetes (P=0.017), cholelithiasis (P=0.000) and Apo A (P=0.000) were strongly inversely correlated with GC. Conclusion: Cholelithiasis, HBV infection and metabolic symptoms may be potential risk factors for the development of biliary tract cancer.

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Section: Discussionmentioning

confidence: 99%

The Metabolic Syndrome and Risk Factors for Biliary Tract Cancer: A Case-control Study in China

Wu¹,

He²,

Yu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Only three similar cases [19,22,30] have been previously reported, and this condition is considered to be very rare. According to several earlier reports [37][38][39] , hepatitis C virus (HCV)-related chronic hepatitis and cirrhosis are major risk factors for both HCC and CCC. The patient described in this report was found to be positive for HCV.…”

Section: Discussionmentioning

confidence: 99%

Synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type C liver cirrhosis

Watanabe

Sakata²,

Ishikawa³

et al. 2009

WJH

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As a result of having undergone computed tomography (CT), a 75-year-old woman with type-C liver cirrhosiswas shown to have two tumors on the ventral and dorsal sides of subsegment 3 (S3). The tumor on the ventral side was diagnosed as a classic hepatocellular carcinoma (HCC), while that on the dorsal side was considered atypical for a HCC. Although the indocyanine green (ICG) findings indicated poor hepatic reserve, the prothrombin time (PT) was relatively good. An operation was performed in February 2007; however, this resulted in exploratory laparotomy. Dynamic CT performed 12 mo after the operation revealed that the tumor on the dorsal side of S3 had apparently increased. The marginal portion of the tumor was shown to be in the early and parenchymal phases, while the internal portion was found to have grown only slightly in the delayed phase. We diagnosed this tumor as a cholangiocellular carcinoma (CCC). S3 subsegmentectomy was performed in April 2008. The tumor on the ventral side was pathologically diagnosed as a moderately differentiated HCC, and that on the dorsal side was diagnosed as a CCC. We can therefore report a rare case of synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type-C liver cirrhosis. We also add a literature review for all the reported cases published in Japan and around the world, and summarize the features of double cancer exhibiting both HCC and CCC.

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“…While a¯atoxin B, a major etiological factor from speci®c region in China, is usually not considered as a risk factor in Hong Kong and Taiwan. On the contrary, chronic hepatitis C infection is more commonly observed in Japan, United States and Europe and recently, the association of chronic HCV infection and HCC has been reported from these regions (Tomimatsu et al, 1993;Gerber et al, 1992). Furthermore, HCC associated with chronic alcoholic liver disease and hemochromatosis are more commonly reported from Western populations such as Australia, Europe and United States.…”

Section: Discussionmentioning

confidence: 99%

High frequency of p16INK4A gene alterations in hepatocellular carcinoma

et al. 1999

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The tumor suppressor gene p16 (CDKN2/MTS-1/ INK4A) is an important component of the cell cycle and inactivation of the gene has been found in a variety of human cancers. In order to investigate the role of p16 gene in the tumorigenesis of hepatocellular carcinoma (HCC), 48 cases of HCC were analysed for p16 alterations by: methylation-speci®c PCR (MSP) to determine the methylation status of the p16 promoter region; comparative multiplex PCR to detect homozygous deletion; PCR ± SSCP and DNA sequencing analysis to identify mutation of the p16 gene. We found high frequency of hypermethylation of the 5' CpG island of the p16 gene in 30 of 48 cases (62.5%) of HCC tumors. Moreover, homozygous deletion at p16 region were present in ®ve of 48 cases (10.4%); and missense mutation were detected in three of 48 cases (6.3%). The overall frequency of p16 alterations, including homozygous deletion, mutation and hypermethylation, in HCC tumors was 70.8% (34 of 48 cases). These ®ndings suggest that: (a) the inactivation of the p16 is a frequent event in HCC; (b) the p16 gene is inactivated by multiple mechanisms including homozygous deletion, promoter hypermethylation and point mutation; (c) the most common somatic alteration of the p16 gene in HCC is de novo hypermethylation of the 5' CpG island; and (d) in contrast to other studies, high frequency of genomic alterations are not uncommon in the 9p21 of the p16 gene. Our results strongly suggest that the p16 gene plays an important role in the pathogenesis of HCC.

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Hepatitis C virus antibody in patients with primary liver cancer (hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma) in Japan

Cited by 99 publications

References 20 publications

The Metabolic Syndrome and Risk Factors for Biliary Tract Cancer: A Case-control Study in China

The Metabolic Syndrome and Risk Factors for Biliary Tract Cancer: A Case-control Study in China

Synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type C liver cirrhosis

High frequency of p16INK4A gene alterations in hepatocellular carcinoma

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