Hepatitis C virus co-infection among people living with HIV/AIDS in a Nigerian Teaching Hospital

Mabayoje, V. O.; Muhibi, Musa Abidemi; Akindele, Rasaq Akintunde; Akinleye, C.A.; Mabayoje, P.S.; Babatunde, O.S.

doi:10.1016/j.hivar.2013.09.003

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…The disease has evolved from a life-threatening diagnosis to a chronic aliment though, with attendant problems of chronic diseases including side effects of long-term therapy. Notable among these is the metabolic syndrome (lipodystrophy), co-infection with other viruses, hepatitis C virus co-infection being the most notorious [4]. In previous studies carried out among our HIV positive clients, 23.2% were found to be co-infected with hepatitis C virus [4].…”

Section: Introductionmentioning

confidence: 82%

“…Notable among these is the metabolic syndrome (lipodystrophy), co-infection with other viruses, hepatitis C virus co-infection being the most notorious [4]. In previous studies carried out among our HIV positive clients, 23.2% were found to be co-infected with hepatitis C virus [4]. Most populations of HIV patients worldwide are generally thought to be co-infected with hepatitis C virus with figures as high as a third of whole populations.…”

Section: Introductionmentioning

confidence: 83%

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Validity and Reliability of Total Lymphocyte Count as Alternative Biomarker for CD4 Count in the Management of HIV Positive Patients on HAART in Osogbo, Nigeria

Egbewale¹,

Oyedeji²,

Mabayoje³

et al. 2015

WJA

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Introduction: To determine the possibility of utilizing total lymphocyte counts (TLC) instead of CD4 counts in the initiation and management of patients with HIV on highly active antiretroviral therapy (HAART). The commencement of HAART CD4 lymphocytes has been employed in the management HIV. However it has been found that determination of CD4 counts is expensive and somewhat laborious to perform in already overburdened healthcare systems especially in the developing countries. Methodology: Five hundred and three (503) consenting patients already on HAART (commenced at CD4 count < 350 cells/µl) who attended our HIV clinic between February 2014 and February 2015 were enrolled into the study. The patients had already been diagnosed as HIV positive. Kappa statistic was computed as a measure of reliability of TLC. Various cutoff marks for TLC in respect of the CD4 counts were determined in addition to the computation of both sensitivity and specificity. Receiver operating curves (ROC), showing area under the curve indicating agreement in classification, were plotted. Results: Majority of patients were female (73.8%). Most of the patients were in the age range of 25-34 years (37.2%). Males were found to * Corresponding author. B. E. Egbewale et al. 314 be significantly older than females (P < 0.05). Area under the receiver operating curves (ROC) revealed that 4 out of 10 patients would be missed using total lymphocyte count (TLC) as the indicator for commencement of HAART. A low correlation coefficient and Kappa statistic r = 0.18, and K = 0.20 respectively, were observed between TLCs and CD4 counts. Conclusion: Total lymphocyte count is not a suitable alternative to CD4 counts in the management of HIV/AIDS.

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Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 83%

Validity and Reliability of Total Lymphocyte Count as Alternative Biomarker for CD4 Count in the Management of HIV Positive Patients on HAART in Osogbo, Nigeria

Egbewale¹,

Oyedeji²,

Mabayoje³

et al. 2015

WJA

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“…Drugs associated with this include starvudine [3], lopinavir/ritonavir. Other complications are co-infection with tuberculosis and co-infection with other viruses [4] [5] [6].…”

Section: Introductionmentioning

confidence: 99%

“…A lot of emphasis has been placed on co-infection with hepatitis C because of the effect of HIV/HCV has on the hepatic system. It could lead to liver fibrosis, cirrhosis and a particular aggressive form of hepatic carcinoma [4]. Since it is possible for other viruses to be present alongside HIV in a patient who is HIV positive, it is important to investigate such a patient for the presence of other viruses especially the hepatic viruses.…”

Section: Introductionmentioning

confidence: 99%

“…Once HIV is diagnosed in a patient the patient is then screened for these viruses and managed based on the findings [5]. In a study carried out in our facility it was found that 23.2% were found to be co-infected with HCV [4]. These patients are therefore prone to the more aggressive effects of HIV/HCV mentioned above, and should be managed appropriately.…”

Section: Introductionmentioning

confidence: 99%

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Screening Outcomes of Hepatitis B and E among HIV Patients on HAART in Osogbo, South Western Nigeria

Egbewale¹,

Mabayoje²,

Muhibi³

et al. 2016

WJA

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Background: The lives of patients living with HIV/AIDs have improved in terms of longer life expectancy and quality. This has seen the emergence of complications of the disease and the drugs such as metabolic syndrome and re-emergence of tuberculosis. Co-infection with other viruses especially the hepatic viruses has also become a major source of concern. The aim of this research is to determine the incidence of hepatitis B and E among this group of patients. Methods and Findings: Blood samples were collected from 156 consecutive HIV positive patients on HAART, informed consent having been obtained previously. The patients were screened both for hepatitis B and E using standard procedures. A questionnaire was administered to all participants. The results are illustrated with tables following analysis with SPSS version 10. It was found that 24.5% were positive for hepatitis E while 7.8% were positive for hepatitis B. It was also found that educational status was the only statistical significant variable for HEV co-infection. Taking the value of alanine transaminase to be 12 U/L as upper limit of normal, the mean value for HEV positive patients obtained was 13.8U/L while for those HBV positive was 10U/L. Conclusion: From the findings, more emphasis should be placed on improving education of the populace. More research should be carried out to determine what subtypes of the viruses are present and their effects on the hepatic system using preferably non-invasive techniques. Also the variability of hepatic enzymatic activity needs more analysis.

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Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis

Platt

Easterbrook

Gower

et al. 2016

The Lancet Infectious Diseases

611

503

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Hepatitis C virus co-infection among people living with HIV/AIDS in a Nigerian Teaching Hospital

Cited by 8 publications

References 20 publications

Validity and Reliability of Total Lymphocyte Count as Alternative Biomarker for CD4 Count in the Management of HIV Positive Patients on HAART in Osogbo, Nigeria

Validity and Reliability of Total Lymphocyte Count as Alternative Biomarker for CD4 Count in the Management of HIV Positive Patients on HAART in Osogbo, Nigeria

Screening Outcomes of Hepatitis B and E among HIV Patients on HAART in Osogbo, South Western Nigeria

Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis

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