2015
DOI: 10.1016/j.canlet.2015.03.032
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Hepatitis C virus core protein induces epithelial–mesenchymal transition in human hepatocytes by upregulating E12/E47 levels

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Cited by 20 publications
(18 citation statements)
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“…EDIL3 interacts with avb3 integrin to promote EMT, metastasis and angiogenesis through the activation of MAPK/ Erk and TGF-b signalling [65]. Studies focusing on HCV-associated HCC revealed that the transcriptional E-cadherin repressors E12 and E47 are increased upon expression of the HCV core protein, which blocks their degradation and contributes to EMT progression [66].…”
Section: Mechanisms Of Emt In Hccmentioning
confidence: 99%
“…EDIL3 interacts with avb3 integrin to promote EMT, metastasis and angiogenesis through the activation of MAPK/ Erk and TGF-b signalling [65]. Studies focusing on HCV-associated HCC revealed that the transcriptional E-cadherin repressors E12 and E47 are increased upon expression of the HCV core protein, which blocks their degradation and contributes to EMT progression [66].…”
Section: Mechanisms Of Emt In Hccmentioning
confidence: 99%
“…21 TCF3 was recognized to inactivate the E-cadherin promoter and repress E-cadherin expression. [22][23][24] MMP9 were reported to have the ability to induce EMT, 25 and to grow HCC, 26 and they are related to poor prognosis. 27 As well as TMN staging system, this risk scoring system using these four EMT-related genes could predict prognosis among patients with HCC with HCV infection.…”
Section: Discussionmentioning
confidence: 99%
“…The ubiquitin‐proteasome system (UPS) is a selective proteolytic system in which substrates are recognized and tagged with ubiquitin for processive degradation by the proteasome . UPS is in charge of degrading 80‐90% of proteins, which is central to regulating cellular function and maintaining protein homeostasis including cell cycle . S‐phase kinase‐associated protein‐1 (SKF‐1)‐cullin 1 (CUL1)‐F‐box protein (SCF) is the largest subfamily of E3 ligases regulating cell cycle progression at the G1/S transition .…”
Section: Discussionmentioning
confidence: 99%
“…21,22 UPS is in charge of degrading 80-90% of proteins, which is central to regulating cellular function and maintaining protein homeostasis including cell cycle. 23,24 S-phase kinase-associated protein-1 (SKF-1)-cullin 1 (CUL1)-F-box protein (SCF) is the largest subfamily of E3 ligases regulating cell cycle progression at the G1/S transition. 25 SKP2 is well known as the F-box of the SCFSkp2 ligase and was found to be an oncoprotein in HCC.…”
Section: Discussionmentioning
confidence: 99%