Hepatitis C virus does not infect muscle, the intervertebral disk, or the meniscus in patients with chronic hepatitis C

Bartolomé, Javier; Rodríguez‐Iñigo, Elena; Erice, Alejo; Vidal, Sonia; Castillo, Inmaculada; Carréño, Vicente

doi:10.1002/jmv.21005

Cited by 1 publication

(1 citation statement)

References 15 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, apart from a specific role for MC in some cases of arthralgia, there is no overarching evidence for a pathogenic role of the virus in most presentations of chronic pain. For example, histopathological presence of HCV in muscles of myalgia sufferers [13, 20] and an increased prevalence of HCV in fibromyalgia patients have not been consistently found [21, 22]. …”

Section: Introductionmentioning

confidence: 99%

Measuring the Response of Extrahepatic Symptoms and Quality of Life to Antiviral Treatment in Patients with Hepatitis C

Isaacs

Abdelaziz

Keller

et al. 2013

Hepatitis Research and Treatment

View full text Add to dashboard Cite

Background. HCV infection is associated with musculoskeletal manifestations such as chronic widespread pain, sicca syndrome, polyarthritis, and a reduced HRQOL. Little data is available on the effect of treatment on these manifestations. This study measured changes in extrahepatic symptoms and HRQOL before and after antiviral treatment in a large UK patient cohort. Methods. 118 patients completed HQLQ and rheumatological questionnaires before and after treatment with pegylated interferon-α and ribavirin, with specific regard to chronic widespread pain, sicca syndrome, and sustained virological response. Results. There was significant improvement in HQLQ domains of physical functioning, physical disability, social functioning, limitations and health distress due to hepatitis, and general health. There was significant deterioration in domains of positive well-being, health distress, and mental health. There was a significant decline prevalence of CWP (26.3% versus 15.3%, P = 0.015). Sicca syndrome prevalence fell insignificantly (12.7% versus 11%). SVR was associated positively with all HRQOL changes and significantly with CWP remission. Conclusions. HCV antivirals significantly improve poor HRQOL scores and CWP. Before treatment, both were common, coassociated, and unaccounted for through mixed cryoglobulinemia alone. Although a role of the hepatitis C virus in CWP cannot be deduced by these results, symptomatic improvement via antiviral treatment exists for this subset of patients.

show abstract

Section: Introductionmentioning

confidence: 99%