Hepatitis C Virus Entry into Macrophages/Monocytes Mainly Depends on the Phagocytosis of Macrophages

Liu, Yuan; Wang, Wenbo; Zou, Ziying; Hu, Zonghai; Fan, Quanshui; Xiong, Jie

doi:10.1007/s10620-018-5401-0

Cited by 18 publications

(12 citation statements)

References 35 publications

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“…In vitro studies have shown a low expression of NKG2D, NKp30, and IFNγ on NK cells together with a decrease in their cytolytic activity when directly co-cultured in HCV-infected hepatocytes [ 113 ]. Unlike hepatocytes, HCV uptake by macrophages is not CD81-dependent; rather, macrophages engulf HCV particles, leading to the release of the inflammatory cytokines IL6 and IL-1β into the surrounding microenvironment [ 114 ]. HCV uptake eventually triggered macrophage apoptosis and death [ 114 ].…”

Section: Host Immune Response To Hepatitis C Infectionmentioning

confidence: 99%

Innate and Adaptive Immunopathogeneses in Viral Hepatitis; Crucial Determinants of Hepatocellular Carcinoma

Zaki

Fathi

Samir

et al. 2022

Cancers

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Viral hepatitis B (HBV) and hepatitis C (HCV) infections remain the most common risk factors for the development of hepatocellular carcinoma (HCC), and their heterogeneous distribution influences the global prevalence of this common type of liver cancer. Typical hepatitis infection elicits various immune responses within the liver microenvironment, and viral persistence induces chronic liver inflammation and carcinogenesis. HBV is directly mutagenic but can also cause low-grade liver inflammation characterized by episodes of intermittent high-grade liver inflammation, liver fibrosis, and cirrhosis, which can progress to decompensated liver disease and HCC. Equally, the absence of key innate and adaptive immune responses in chronic HCV infection dampens viral eradication and induces an exhausted and immunosuppressive liver niche that favors HCC development and progression. The objectives of this review are to (i) discuss the epidemiological pattern of HBV and HCV infections, (ii) understand the host immune response to acute and chronic viral hepatitis, and (iii) explore the link between this diseased immune environment and the development and progression of HCC in preclinical models and HCC patients.

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Section: Host Immune Response To Hepatitis C Infectionmentioning

confidence: 99%

Innate and Adaptive Immunopathogeneses in Viral Hepatitis; Crucial Determinants of Hepatocellular Carcinoma

Zaki

Fathi

Samir

et al. 2022

Cancers

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“…Apoptosisa form of cell damage in various liver diseasesis worthy of study with regard to its role and significance in the pathogenesis and progression of viral hepatitis [42,43]. Studies have shown that hepatocyte apoptosis is an effective defense mechanism against infection by pathogenic microorganisms and the spread of infection; moreover, it plays an important regulatory role in the malignant transformation of hepatocytes [44]. The caspase family plays an important role in hepatocellular apoptosis.…”

Section: Discussionmentioning

confidence: 99%

A bioinformatics investigation into the pharmacological mechanisms of the effect of the Yinchenhao decoction on hepatitis C based on network pharmacology

Zhang

Liu

et al. 2020

BMC Complement Med Ther

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Background Globally, more than 170 million people are infected with hepatitis C virus, a major cause of cirrhosis and hepatocellular carcinoma. The Yinchenhao Decoction (YCHD) is a classic formula comprising three herbal medicines. This decoction have long been used in China for clinically treating acute and chronic infectious hepatitis and other liver and gallbladder damp heat-accumulation disorders. Methods In this study, we identified 32 active ingredients and 200 hepatitis C proteins and established a compound-predicted target network and a hepatitis C protein–protein interaction network by using Cytoscape 3.6.1. Then, we systematically analyzed the potential targets of the YCHD for the treatment of hepatitis C. Finally, molecular docking was applied to verify the key targets. In addition, we analyzed the mechanism of action of the predicted targets by the Kyoto Encyclopedia of Genes and Genomes and gene ontology analyses. Results This study adopted a network pharmacology approach, mainly comprising target prediction, network construction, module detection, functional enrichment analysis, and molecular docking to systematically investigate the mechanisms of action of the YCHD in hepatitis C. The targets of the YCHD in the treatment of hepatitis C mainly involved PIK3CG, CASP3, BCL2, CASP8, and MMP1. The module and pathway enrichment analyses showed that the YCHD had the potential to influence varieties of biological pathways, including the TNF signaling pathway, Ras signaling pathway, PI3K-Akt signaling pathway, FoxO signaling pathway, and pathways in cancer, that play an important role in the pathogenesis of hepatitis C. Conclusion The results of this study preliminarily verified the basic pharmacological effects and related mechanisms of the YCHD in the treatment of hepatitis C.

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“…HPβCD and/or RAMEB also interfere with the infectivity of viruses responsible for chronic infections, namely the varicela-zooster virus (VZV) that causes chickenpox [59], and the hepatitis C virus (HCV) [60,61]. For the treatment of hepatitis C, new cyclodextrins are being developed based on fullerene conjugation (in a similar way to some CDs described for influenza treatment).…”

Section: Other Pathogenic Viruses Targeted By Cdsmentioning

confidence: 99%

Cyclodextrins: Emerging Medicines of the New Millennium

2019

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Cyclodextrins, since their discovery in the late 19th century, were mainly regarded as excipients. Nevertheless, developments in cyclodextrin research have shown that some of these hosts can capture and include biomolecules, highlighting fatty acids and cholesterol, which implies that they are not inert and that their action may be used in specific medicinal purposes. The present review, centered on literature reports from the year 2000 until the present day, presents a comprehensive description of the known biological activities of cyclodextrins and their implications for medicinal applications. The paper is divided into two main sections, one devoted to the properties and applications of cyclodextrins as active pharmaceutical ingredients in a variety of pathologies, from infectious ailments to cardiovascular dysfunctions and metabolic diseases. The second section is dedicated to the use of cyclodextrins in a range of biomedical technologies.

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Hepatitis C Virus Entry into Macrophages/Monocytes Mainly Depends on the Phagocytosis of Macrophages

Cited by 18 publications

References 35 publications

Innate and Adaptive Immunopathogeneses in Viral Hepatitis; Crucial Determinants of Hepatocellular Carcinoma

Innate and Adaptive Immunopathogeneses in Viral Hepatitis; Crucial Determinants of Hepatocellular Carcinoma

A bioinformatics investigation into the pharmacological mechanisms of the effect of the Yinchenhao decoction on hepatitis C based on network pharmacology

Cyclodextrins: Emerging Medicines of the New Millennium

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