Hepatitis C Virus (HCV) Occult Infection or Occult HCV RNA Detection?

Lerat, Hervé; Hollinger, F. Blaine

doi:10.1086/380203

Cited by 35 publications

(24 citation statements)

References 31 publications

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“…In addition, PBMCs from 40 of the 57 patients (70%) were found positive for HCV RNA. 10 Genotyping, a test which typically requires the presence of at least 20,000 IU/mL, 41,42 was successful. Core antigen, however, was not detected in liver samples, possibly due to low expression levels.…”

Section: Disease Of Unknown Originmentioning

confidence: 99%

Occult hepatitis C: How convincing are the current data? #

Welker

Zeuzem

2009

Hepatology

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Section: Disease Of Unknown Originmentioning

confidence: 99%

Occult hepatitis C: How convincing are the current data? #

Welker

Zeuzem

2009

Hepatology

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“…Occult HCV infection is recognized as an important cause of persistently elevated liver enzymes in seronegative cases of hepatitis, and of cryptogenic cirrhosis. [10][11][12][13][14][15][16][17] Hepatitis C has the ability to modulate the immune response, which may lead to EM in susceptible individuals. Viral serine protease 3 I inhibits host IFN regulatory factor-3.…”

Section: Discussionmentioning

confidence: 99%

Severe erythema multiforme responding to interferon alfa

Geraminejad¹,

Walling²,

Voigt

et al. 2006

Journal of the American Academy of Dermatology

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“…Chronic HCV infection mostly leads to hepatic cirrhosis before developing HCC [14] . Additionally, occult HCV was also reported in patients with chronic un-explained hepatitis [15] . Thus, both occult HBV and HCV infections contribute to HCC prevalence.…”

Section: Hcv Infectionmentioning

confidence: 99%

Recent insights on risk factors of hepatocellular carcinoma

Abdel-Hamid

2009

WJH

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Hepatocellular carcinoma (HCC) is a disease prevalent in many populations worldwide. It initiates many economic and health problems in management modalities and leads to increasing mortality rates. Worldwide, trials have attempted to discover specific early markers for detection and prediction of the disease, hoping to set a more precise strategy for liver cancer prevention. Unfortunately, many economic, cultural and disciplinary levels contribute to confounding preventive strategies. Many risk factors contribute to predisposition to HCC, which can present individually or simultaneously. Previous articles discussed many risk factors for hepatocellular carcinogenesis; however, most of them didn't consider collectively the most recent data relating to causes. In this article, the pathogenesis and risk factors of HCC are discussed. Most of the intermediary steps of HCC involve molecular and transcriptional events leading to hepatocyte malignant transformation. These steps are mainly triggered by hepatitis B, C or transfusion-transmitted virus, either alone, or with other factors. Diabetes seems to be a major contributing risk factor. Schistosomiasis, a blood infestation, mostly affects Nile basin inhabitants leading to bladder, renal and hepatic cancers. Alcoholism, food and water pollutants and some drugs can also lead to HCC. Additionally, some hereditary diseases, as hemochromatosis, α-1-antitrypsin deficiency and tyrosinaemia are known to lead to the development of HCC, if not well managed.

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Hepatitis C Virus (HCV) Occult Infection or Occult HCV RNA Detection?

Cited by 35 publications

References 31 publications

Occult hepatitis C: How convincing are the current data? #

Occult hepatitis C: How convincing are the current data? #

Severe erythema multiforme responding to interferon alfa

Recent insights on risk factors of hepatocellular carcinoma

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