2020
DOI: 10.1007/s40506-020-00231-8
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Hepatitis C Virus in the Elderly in the Direct-Acting Antiviral Era: from Diagnosis to Cure

Abstract: Purpose of review Hepatitis C (HCV) is the most common cause of viral hepatitis in elderly individuals. This patient population previously experienced suboptimal outcomes with interferon-based regimens. Unfortunately, patients aged 65 years and older were underrepresented in phase 2 and 3 clinical trials with newer direct acting antiviral (DAA) therapies. Since the advent of second-generation DAA in 2013, numerous robust real-world experiences highlighting the efficacy and safety of DAA in the eld… Show more

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Cited by 6 publications
(2 citation statements)
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“…In a previous study including nationwide Korean CHC patients, the mean age was around 57. This suggests an aging trend in Korean patients with HCV wherein, risk factors associated with aging should be taken into consideration when treating CHC patients of older age [17].…”
Section: Discussionmentioning
confidence: 99%
“…In a previous study including nationwide Korean CHC patients, the mean age was around 57. This suggests an aging trend in Korean patients with HCV wherein, risk factors associated with aging should be taken into consideration when treating CHC patients of older age [17].…”
Section: Discussionmentioning
confidence: 99%
“…Generally, our findings are consistent with the observation that fibrosis may not compromise SOF/VEL and SOF/DCV efficacy, but decompensated cirrhosis may undermine SVR 28 . To illustrate these points, Abdul and colleagues noted a significant difference in treatment outcomes between patients with disparate Child-Turcotte-Pugh (CTP) classification (95.5% in CTP A vs. 90.8% in CTP B, p value = 0.010) 29 . Literature also suggests that specific HCV genotypes (e.g., HCV-GT4 subtype 4k, 4q, 4p, and 4r) and the emergence of resistance-associated mutations (RAM) 30 may contribute to virological failure.…”
Section: Discussionmentioning
confidence: 99%