Hepatitis C virus incidence among young street-involved IDUs in relation to injection experience

Roy, Élise; Boudreau, Jean-François; Boivin, Jean‐François

doi:10.1016/j.drugalcdep.2009.01.006

Cited by 63 publications

(50 citation statements)

References 21 publications

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“…In examining this question prospectively in this study, we calculated time to seroconversion for each incident case using the interval between age at first injection and date of seroconversion. For IDUs injecting 4 years or less at baseline, the mean time to HCV seroconversion from onset of injecting was 1.2 years, earlier than detected in previously HCV studies 25,26 and indicating a significantly narrower window of opportunity for behavioral interventions for new heroin-using populations 27 . Three general arenas should be targeted for early intervention:…”

Section: Hcv Incidencementioning

confidence: 59%

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Prevalence and Incidence of HCV Infection among Vietnam Heroin Users with Recent Onset of Injection

et al. 2009

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HCV infection continues to spread at an alarming rate among IDU populations. The available evidence suggests that HCV is acquired relatively quickly following onset of injection. However, there are few prospective studies of HCV acquisition, particularly among IDU populations in resource-poor settings. A sample of young male heroin injectors with recent onset of injection (<4 years) was recruited in Hanoi, Vietnam for a prospective assessment of the early course of injection (n = 179). Both behavioral and biological assessments (including detailed retrospective assessment of injection initiation) were conducted at baseline and repeated at 6-month intervals for a period of 16 months. Variables associated with HCV infection (p value < 0.05) in bivariate analyses were considered for inclusion in logistic regression models to identify risk factors independently associated with HCV infection. HCV incidence was calculated by using the incidence density approach and was expressed in terms of person-years of observation. The baseline of prevalence of HCV was 46%. HCV significantly increased in relation to time since first injection, from 30% in subjects with /=30 months injection risk (p value = 0.0005). In multivariate logistic regression analysis, increasing age, incarceration in a drug detention facility (OR = 2.54; 95%CI 1.05, 6.15), and time since first injection remained significantly associated with HCV infection. Use of injection as primary mode of administration (OR = 2.56; 95%CI 0.98, 6.69) achieved marginal significance. After 16 months of follow-up, the incidence rate of HCV was 23.35 per 100 person-years and the mean time between first injection and first positive HCV test was 1.2 years. HCV is acquired much more rapidly among new injector populations than previously recognized, demonstrating the need for early behavioral intervention among new heroin-user populations. Particularly critical are interventions that target new heroin user populations, including interventions that improve understanding of viral transmission dynamics, that promote alternative strategies for drug sharing, and that delay initiation of injection.

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Section: Hcv Incidencementioning

confidence: 59%

“…Mean age of first injection was 19.69 years (range [13][14][15][16][17][18][19][20][21][22][23][24][25][26]. At the time of their first injection, the vast majority (91.62%) received some form of technical assistance from another person (typically a somewhat older injector) in preparing a heroin solution and injecting it.…”

Section: Patterns Of Heroin Initiationmentioning

confidence: 99%

Prevalence and Incidence of HCV Infection among Vietnam Heroin Users with Recent Onset of Injection

et al. 2009

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“…In 2015, there were 1.7 million new HCV infections globally, with 23% attributable to current injecting drug use (WHO, 2017b), related to the high HCV incidence among PWID in many settings (Hagan, Pouget, Des Jarlais, & Lelutiu-Weinberger, 2008;Morris, et al, 2017;Page, Morris, Hahn, Maher, & Prins, 2013;Wiessing, et al, 2014), particularly in the initial years of injecting (Hagan, et al, 2008;Roy, Boudreau, & Boivin, 2009), and in key vulnerable populations.…”

Section: Epidemiology and Prevention Of Hcv Infection Among Pwidmentioning

confidence: 99%

Elimination of hepatitis C virus infection among PWID: The beginning of a new era of interferon-free DAA therapy

Grebely

Bruneau

Bruggmann

et al. 2017

International Journal of Drug Policy

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“…Injection is one aspect of this behavior (Guichard et al, 2004;Guichard et al, 2006;Toufik et al, 2008). Therefore, the current harm reduction strategies may not be reaching these new groups of injectors and may thus lead to a higher prevalence of HVC, which is often acquired shortly after initiation into injection (Hagan et al, 2004;Maher et al, 2006;Maher et al, 2007;Roy et al, 2009;van den Berg et al, 2007;Bravo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Changing patterns of first injection across key periods of the French Harm Reduction Policy: PrimInject, a cross sectional analysis

Guichard

Guignard

Michels

et al. 2013

Drug and Alcohol Dependence

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Hepatitis C virus incidence among young street-involved IDUs in relation to injection experience

Cited by 63 publications

References 21 publications

Prevalence and Incidence of HCV Infection among Vietnam Heroin Users with Recent Onset of Injection

Prevalence and Incidence of HCV Infection among Vietnam Heroin Users with Recent Onset of Injection

Elimination of hepatitis C virus infection among PWID: The beginning of a new era of interferon-free DAA therapy

Changing patterns of first injection across key periods of the French Harm Reduction Policy: PrimInject, a cross sectional analysis

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