2016
DOI: 10.12659/msm.899591
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Hepatitis C Virus Increases Free Fatty Acids Absorption and Promotes its Replication Via Down-Regulating GADD45α Expression

Abstract: BackgroundHepatitis C virus (HCV) infection, as a major cause of chronic hepatic diseases, is always accompanied with an abnormality of lipid metabolism. The aim of this study was to investigate the pathogenic role of free fatty acids (FFA) in human HCV infection.Material/MethodsPeripheral blood lipid indexes among HCV patients with different viral loads (199 samples) and healthy donors (80 samples) were detected by clinical biochemistry tests. HCV replication and the expression of growth arrest and DNA-damage… Show more

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Cited by 10 publications
(7 citation statements)
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“…In addition, the neutral lipid droplet content increases and the radial distribution of the lipid droplets shifts outward from the nucleus toward the plasma membrane. Increased lipid accumulation has been observed previously in hepatitis C virus-infected Huh7 cells ( 13 ). The CellMask intensity is increased in infected cells due to the prevalence of syncytia where the disappearance of cell boundaries increases staining intensity at the cell edge.…”
Section: Resultssupporting
confidence: 73%
“…In addition, the neutral lipid droplet content increases and the radial distribution of the lipid droplets shifts outward from the nucleus toward the plasma membrane. Increased lipid accumulation has been observed previously in hepatitis C virus-infected Huh7 cells ( 13 ). The CellMask intensity is increased in infected cells due to the prevalence of syncytia where the disappearance of cell boundaries increases staining intensity at the cell edge.…”
Section: Resultssupporting
confidence: 73%
“…The binding of lipoproteins with their receptor leads to the internalization of CT by endocytosis. The decrease of CT, HDL, and LDL, in COVID-19 patients ( Wei et al, 2016 ) could be associated to the formation of viral membrane and to reparation of the host’s membrane after of the budding process to avoid the loss of cell homeostasis. Since the membranes contain especially high amounts of CT, up to a proportion of more than one CT molecule for each PL molecule, this reinforces the permeable characteristic of the lipid bilayer.…”
Section: Discussionmentioning
confidence: 99%
“…Although the exact mechanism for this increase is unknown, it could be related to an elevation in the anaerobic glycolysis caused by SARS-CoV-2 ( Soria-Castro et al, 2020 ). As an example, the HCV induces lipid accumulation in hepatocytes by inhibiting microsomal TG transfer protein activity ( Chen et al, 2016 ). However, in patients with sepsis, hypolipidemia is usually found, and the possible mechanism behind this lipid alteration is a tissue lipoprotein lipase inhibition, an upregulated hepatic TG production, disruption of the synthesis-utilization balance and interaction with cytokines or endotoxins ( Ilias et al, 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…Fatty acids have been shown to support HCV replication in replicon cells (77,78). On the other hand, several recent papers showed that fatty acids inhibit HCV replication (77,(79)(80)(81).…”
Section: Discussionmentioning
confidence: 99%