2019
DOI: 10.3390/v11040378
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Hepatitis C Virus-Induced FUT8 Causes 5-FU Drug Resistance in Human Hepatoma Huh7.5.1 Cells

Abstract: Hepatitis C virus (HCV) is a major cause of human chronic liver disease and hepatocellular carcinoma. Our recent studies showed that α1,6-fucosyltransferase (FUT8), a key glycosyltransferase, was the most up-regulated glycosyltransferase after the HCV infection of human hepatocellular carcinoma Huh7.5.1 cells. Here, we further studied the effects and possible mechanism of FUT8 on the proliferation of HCV and chemotherapy-resistance of HCV-infected Huh7.5.1 cells. The effects of FUT8 on the proliferation and dr… Show more

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Cited by 18 publications
(14 citation statements)
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“…For example, FUT8 activates PI3K-Akt-NF- κ B signaling pathway and promotes the proliferation of HCC cells, it also stimulates the expression of drug-resistant proteins. Inhibition of FUT8 can weaken hepatocyte epidermal growth factor (EGF) and hepatocyte growth factor (HGF), and thus reduce the incidence of liver cancer [ 21 , 22 ]. miR-23a may affect the formation of N-glycochain branches on the cell surface through glucose transferase MGAT3, thereby increasing the metastasis potential of liver cancer, which provides a new idea for the mechanism of action of MGAT3 in tumor metastasis [ 23 , 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…For example, FUT8 activates PI3K-Akt-NF- κ B signaling pathway and promotes the proliferation of HCC cells, it also stimulates the expression of drug-resistant proteins. Inhibition of FUT8 can weaken hepatocyte epidermal growth factor (EGF) and hepatocyte growth factor (HGF), and thus reduce the incidence of liver cancer [ 21 , 22 ]. miR-23a may affect the formation of N-glycochain branches on the cell surface through glucose transferase MGAT3, thereby increasing the metastasis potential of liver cancer, which provides a new idea for the mechanism of action of MGAT3 in tumor metastasis [ 23 , 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…For example, FUT8 activates PI3K-Akt-NF-κB signaling pathway and promotes the proliferation of HCC cells, it also stimulates the expression of drug-resistant proteins. Inhibition of FUT8 can weaken hepatocyte epidermal growth factor (EGF) and hepatocyte growth factor (HGF), and thus reduce the incidence of liver cancer [21,22]. miR-23a may affect the formation of Nglycochain branches on the cell surface through glucose transferase MGAT3, thereby increasing the metastasis potential of liver cancer, which provides a new idea for the mechanism of action of MGAT3 in tumor metastasis [23,24].…”
Section: Discussionmentioning
confidence: 99%
“…Human low metastatic liver cell MHCC-97L was a gift from Prof. Fubing Wang from the Hubei Key Laboratory of Tumor Biological Behaviors of the Zhongnan Hospital of Wuhan University School of Medicine, and high metastatic liver cell HCC-LM3 was purchased from the China Center for Type Culture Collection (CCTCC) of Wuhan University, China. Human hepatocellular carcinoma cells Huh7.5.1, normal liver cells L02, MHCC-97L, and HCC-LM3 were maintained in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% fetal bovine serum (FBS, Gibco) (Invitrogen, USA) at 37°C in a 5% CO 2 atmosphere as previously described ( 20 , 21 ).…”
Section: Methodsmentioning
confidence: 99%