Hepatitis C virus infection in Jeddah city, Saudi Arabia: Seroprevalence and knowledge

Al‐Raddadi, Rajaa; Dashash, Noha A.; Alghamdi, Hani A; AlRaddadi, Zeyad; Alzahrani, Hanan; Alsahafi, Abdullah J.; Algarni, Abdullah; Alghamdi, Majed; Hakim, Raghad F.; Al‐Zalabani, Abdulmohsen H.; Hakim, Fanar; Moria, Feras A.

doi:10.1002/jmv.24973

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Despite the high rate of HBcAb positivity in our cohort, the prevalence of HBsAg positivity was only 0.2%, indicating a marked reduction in the incidence of HBV infection. In a 2017 study conducted in primary health centers, hepatitis HCV seroprevalence was estimated to be 0.38%, with a higher prevalence attributed to those aged > 37 years, which is consistent with our findings of HCV positivity (0.4%) [25].…”

Section: Plos Onesupporting

confidence: 91%

Blood utilization and quality indicators at a university hospital in the Eastern Province of Saudi Arabia

et al. 2022

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Background Blood transfusion is a common, essential procedure when treating many different medical and surgical conditions. Efficient utilization of blood bank facilities by frequent auditing is crucial; however, few studies have examined blood utilization in Saudi Arabia. We aimed to review the blood ordering patterns and transfusion practices, and blood bank audit effectiveness at a single center in Saudi Arabia and compare our results with those of a similar study performed in the same center 20 years ago. Materials and methods This study was a retrospective descriptive chart review of all healthy blood donors and recipients from January 1, 2016, to December 31, 2020. We evaluated the crossmatching-to-transfusion ratio (C/T) as an indicator of blood bank utilization and compared the findings with those of the previous study. We also evaluated changes in blood bank utilization during the coronavirus disease 2019 pandemic. Results Findings from 27,414 donors (men, 94.9%; mean age, 32.2 + 9.6 years) showed a 71% increase in blood donations compared to that of 2000. The donations gradually increased over the years, peaking just before COVID-19 pandemic started in March 2020. For 3,836 patients, 13,324 units of blood were crossmatched (average, 3.47 crossmatch/patient), with 23% of the crossmatch requests from surgical departments. The average C/T ratio, transfusion index, and transfusion probability (T%) were 1.37, 2.55, and 73.2%, respectively. The C/T ratio decreased by 54% between 2000 and 2020. During the pandemic, crossmatching decreased by 26% between 2019 and 2020, but with comparable C/T ratio in 2019 (1.45) and 2020 (1.39). Conclusion Our hospital blood bank utilization improved over the past 20 years, showing increased donations, reduced C/T ratio, and increased T%. This improvement emphasizes the importance of blood donation campaigns, blood bank auditing, restrictive transfusion guidelines, and physician education.

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Section: Plos Onesupporting

confidence: 91%

Blood utilization and quality indicators at a university hospital in the Eastern Province of Saudi Arabia

et al. 2022

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“…Despite that epidemiological data on HCV in Saudi Arabia is deficient [12,13] and also limited by small sample size [14], it has been speculated that viral hepatitis is highly endemic in the southwestern region in Saudi Arabia [15]. However, estimating the overall prevalence of HCV in the country is difficult due to lack of more studies in different geographical regions [16] with conflicting results regarding the actual prevalence [17]. It was identified that genotype 4 is the most predominant in Saudi Arabia followed by genotype 1 [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis C Virus Genotypes in the Southern Region, Saudi Arabia

Alkahtani

Alsultan

Hakami

et al. 2019

Preprint

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Aim: The aim of this study was to investigate the prevalence of HCV genotypes in the Southern Region, Saudi Arabia. Materials & methods: A total of 76 HCV-positive individuals were selected for this study, including 34 males and 42 females, both acute and chronic patients. All HCV isolates were genotyped by direct sequencing of the 5´UTR region. The Chemistry profile, viral load and history of blood transfusion were collected from the hospital record. Results: The most common genotype was gt 4 (48.7%) followed by gt 1 (34.2%) and gt 3 (14.5%). Genotype 2 (2.6%) was only found in elderly male individuals. Patients with history of blood transfusion showed a high percentage of genotype 1 compared to the total number of all patients with genotype 1 (23% and 11% respectively).Biochemical assay showed high level of ALT particularly in genotype 4. No significant relationship was observed between HCV genotype and AST level between genotypes. The viral load was higher in HCV patients received blood transfusion than other genotypes. Conclusion: The prevalence of genotypes in this study confirmed the observation of other investigations, but no link was found between sex and genotype. There might be an association between blood donation in the past and infections with genotype 1.

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Hepatitis A virus knowledge and immunization attitudes and practices in the United Arab Emirates community

Samara

Barqawi

Aboelsoud

et al. 2021

Sci Rep

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Annually, 1.5 million cases of hepatitis A infection occur worldwide. The United Arab Emirates (U.A.E.) has seen a decrease in infection rates and seroprevalence coupled with an increase in the average age of infection. This study aimed to assess the U.A.E. society’s hepatitis A knowledge, and attitudes and vaccination practices, with the applicability of its introduction into the local immunization schedule. A self-administered, 50-item questionnaire was used to collect data from the four most populous cities in the U.A.E., between January and March 2020. A total of 458 responses were collected and analysed using IBM-SPSS-26, R-4.0.0 and Matplotlib-v3.2.1. Females had better attitudes (P = 0.036), practices (P < 0.0005), immunization schedule knowledge (AOR = 3.019; CI 1.482–6.678), and appreciation of the immunization schedule (AOR = 2.141; CI 1.310–3.499). A higher level of perceived knowledge was associated with an actual better knowledge (P < 0.0005), better practices (P = 0.011), and increased willingness to get vaccinated (AOR = 1.988; CI 1.032–3.828). Respondents were more likely to vaccinate their children against HAV if the vaccine were introduced into the National Immunization Program (P < 0.0005). Overall, disease knowledge was lacking but with positive attitudes and poor practices. There is high trust in the National Immunization Program and a potential for improving poor practices through local awareness campaigns.

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Hepatitis C virus infection in Jeddah city, Saudi Arabia: Seroprevalence and knowledge

Cited by 5 publications

References 18 publications

Blood utilization and quality indicators at a university hospital in the Eastern Province of Saudi Arabia

Blood utilization and quality indicators at a university hospital in the Eastern Province of Saudi Arabia

Prevalence of Hepatitis C Virus Genotypes in the Southern Region, Saudi Arabia

Hepatitis A virus knowledge and immunization attitudes and practices in the United Arab Emirates community

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