Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Fabrizi, Fabrizio; Verdesca, Simona; Messa, Piergiorgio; Martin, Paul

doi:10.1007/s10620-015-3801-y

Cited by 119 publications

(116 citation statements)

References 55 publications

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“…Most comorbid conditions and unadjusted outcome rates increased across groups from patients with no evidence of renal disease to non-ESRD There is an established relationship between HCV and CKD. Patients with HCV are at risk of developing certain types of renal disease (e.g., mixed cryoglobulinemia with membranoproliferative glomerulonephritis) [11] and may be more likely to develop CKD [12] , and CKD may progress faster in patients with HCV than in those without HCV [13][14][15] . In ESRD patients on maintenance dialysis, the prevalence of HCV increases with dialysis duration [16] , potentially due to transmission from blood products or contaminated equipment [11] .…”

mentioning

confidence: 99%

Impact of Renal Disease on Patients with Hepatitis C: A Retrospective Analysis of Disease Burden, Clinical Outcomes, and Health Care Utilization and Cost

Solid

Peter

Natwick

et al. 2017

Nephron

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Background/Aims: Few studies explore the magnitude of the disease burden and health care utilization imposed by renal disease among patients with hepatitis C virus (HCV). We aimed to describe the characteristics, outcomes, and health care utilization and costs of patients with HCV with and without renal impairment. Methods: This retrospective analysis used 2 administrative claims databases: the US commercially insured population in Truven Health MarketScan® data (aged 20-64 years), and the US Medicare fee-for-service population in the Medicare 20% sample (aged ≥65 years). Baseline characteristics and comorbid conditions were identified from claims during 2011; patients were followed for up to 1 year (beginning January 1, 2012) to identify health outcomes of interest and health care utilization and costs. Results: In the MarketScan and Medicare databases, 35,965 and 10,608 patients with HCV were identified, 8.5 and 26.5% with evidence of renal disease (chronic kidney disease [CKD] or end-stage renal disease [ESRD]). Most comorbid conditions and unadjusted outcome rates increased across groups from patients with no evidence of renal disease to non-ESRD CKD to ESRD. Health care utilization followed a similar pattern, as did the costs. Conclusions: Our findings suggest that HCV patients with concurrent renal disease have significantly more comorbidity, a higher likelihood of negative health outcomes, and higher health care utilization and costs.

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mentioning

confidence: 99%

Impact of Renal Disease on Patients with Hepatitis C: A Retrospective Analysis of Disease Burden, Clinical Outcomes, and Health Care Utilization and Cost

Solid

Peter

Natwick

et al. 2017

Nephron

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“…In this study patients with T2DM and chronic hepatitis B virus infection were more likely to develop end-stage renal disease than patients without hepatitis B virus 49 . Further support for the notion that liver inflammation (irrespective of its aetiology) is important in mediating a link between NAFLD and CKD is found in other studies that have investigated the known links between hepatitis C virus infection and atherosclerosis and kidney disease [50][51][52] .…”

Section: Predisposing Factors Contributing To Nash: Diet Insulin Resmentioning

confidence: 66%

“…To date, the potential anti-fibrogenic effect of these drugs is increasingly recognized in both animal and human studies 50 . Some preliminary clinical trials demonstrated that losartan or valsartan improved insulin resistance, serum liver enzymes and other surrogate markers of NASH, whereas telmisartan improved hepatic necroinflammation and fibrosis 132,133 .…”

Section: Management and Treatment Options For Nafldmentioning

confidence: 99%

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

2017

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“…12,13 Information on HBsAg status was registered at the time of enrollment. If similar data were reported in more than one study, the recent study was involved in the analysis of results.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Relationship between hepatitis B virus infection and chronic kidney disease in Asian populations: a meta-analysis

et al. 2016

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Purpose: To evaluate the association of Chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD). Methods: We searched Embase, Grateful Med, Ovid, PubMed, and the China Biological Medicine Database. A meta-analysis was performed to assess whether HBV infection plays an independent impact on the development of CKD in the general population. Relative risks of CKD (defined as reduced glomerular filtration rate or proteinuria) according to HBsAg serologic status were studied. Results: Six eligible clinical studies (189,709 individuals in total) were included in the analysis. There was no association between HBsAg seropositive status and prevalence of CKD, the summary estimate for adjusted relative risk (RR) was 1.16 (95% confidence interval (CI), 0.78, 1.71; p ¼ .46) according to the random-effects model, and between studies heterogeneity was noted (p values by Q test <0.001). Also, there were no significant associations between positive HBV serologic status and low eGFR (adjusted relative risk, 0.95; 95% CI, 0.72, 1.26; p ¼ .72) or proteinuria (adjusted relative risk, 1.00; 95% CI, 0.83, 1.20; p ¼ .99).Conclusions: This meta-analysis shows that there was no association between exposure to HBV and the risk of developing CKD in Asian populations. ARTICLE HISTORY

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Hepatitis C Virus Infection Increases the Risk of Developing Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Abstract: HCV infection is associated with an increased risk of developing chronic kidney disease in the adult general population.

Cited by 119 publications

References 55 publications

Impact of Renal Disease on Patients with Hepatitis C: A Retrospective Analysis of Disease Burden, Clinical Outcomes, and Health Care Utilization and Cost

Impact of Renal Disease on Patients with Hepatitis C: A Retrospective Analysis of Disease Burden, Clinical Outcomes, and Health Care Utilization and Cost

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

Relationship between hepatitis B virus infection and chronic kidney disease in Asian populations: a meta-analysis

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