Hepatitis C Virus Infection Is Not An Independent Risk Factor For Obstructive Lung Disease

Fischer, William A.; Drummond, M.B.; Merlo, Christian A.; Thomas, David L.; Brown, Robert H.; Mehta, Shruti H.; Wise, Robert A.; Kirk, Greg

doi:10.3109/15412555.2013.800854

Cited by 10 publications

(8 citation statements)

References 26 publications

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“…We did not find any independent correlation with the use of cannabis, IDU, depression, inactive status or long-term illness, probably because these factors were associated with smoking [31]. We did not find any correlation between ART exposure and COPD, nor between hepatitis and COPD, contrary to some previous studies using smaller populations [10,12,14,32]. Some previous studies also discussed an association between pneumocystis pneumonia or tuberculosis pneumonia with COPD [10, 19].…”

Section: Discussioncontrasting

confidence: 99%

COPD in HIV-Infected Patients: CD4 Cell Count Highly Correlated

Risso

Guillouet-de-Salvador

Valério

et al. 2017

PLoS ONE

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BackgroundCOPD is a frequent and significant cause of respiratory morbidity in HIV-infected patients despite the control of HIV. We aimed to analyze the factors correlated with COPD in this population to evaluate the existence of specific indicators of vulnerability in this population.Methods and Findings623 HIV-infected outpatients were enrolled during one year. This population was characterised by a dedicated questionnaire and electronic patient records. COPD screening was performed according to recommended spirometric criteria. The prevalence of COPD was 9.0%. Age and smoking were independently correlated with COPD (OR, 1.61 per 10 years increase, P = 0.007; OR, 1.28 per 10 pack-year increase, P = 0.003, respectively). Body mass index (BMI) and CD4 cell-count were independently and negatively correlated with COPD (OR, 0.78, P < 0.001; 0R, 0.77 per 100 cell/mm3 increase, P < 0.001, respectively). Among COPD patients, 77% did not know their diagnosis. Five COPD-patients never smoked and 44.2% did not have any respiratory symptoms and so were not eligible to perform a spirometry according to the guidelines.ConclusionsIn addition to known risk factors, immune defect through CD4 cell count was independently and strongly correlated with COPD. COPD is largely underdiagnosed and thus unmanaged. However, early management and urgent smoking cessation are essential to improve prognosis. Clinicians’ awareness on the particular vulnerability for COPD in HIV-infected patients is crucial. Moreover, indications to perform conventional spirometry to diagnose COPD may include more parameters than tobacco-smoking and respiratory complaints with a particular concern toward patients with a profound CD4 cell count defect.

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Section: Discussioncontrasting

confidence: 99%

COPD in HIV-Infected Patients: CD4 Cell Count Highly Correlated

Risso

Guillouet-de-Salvador

Valério

et al. 2017

PLoS ONE

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“…Other identified independent factors in some groups have included include low body mass index (BMI) [41, 50, 59] , injection drug use [48, 49] , history of bacterial pneumonia [27] or colonization [61] , Pneumocystis pneumonia [35, 49, 66] , pulmonary tuberculosis [52, 59] , and co-infection with infectious hepatitis C [41, 50, 66] . The contribution of hepatitis C to airflow obstruction beyond injection drug use remains unclear, and not all studies find an independent effect [67] .…”

Section: Non-infectious Pulmonary Complications Of Hivmentioning

confidence: 99%

Pulmonary disease in HIV-infected adults in the era of antiretroviral therapy

Fitzpatrick

Kunisaki

Morris

2018

Aids

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: HIV in the antiretroviral therapy era is characterized by multimorbidity and the frequent occurrence of HIV-associated non-AIDS chronic health conditions. Respiratory symptoms and chronic pulmonary diseases, including chronic obstructive pulmonary disease, asthma, and cardiopulmonary dysfunction, are among the conditions that may present in persons living with HIV. Tobacco smoking, which is disproportionately high among persons living HIV, strongly contributes to the risk of pulmonary disease. Additionally, features associated with and at times unique to HIV, including persistent inflammation, immune cell activation, oxidative stress, and dysbiosis, may also contribute. This review summarizes the available literature regarding epidemiology of and risk factors for respiratory symptoms and chronic pulmonary disease in the current era.

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“…Several epidemiological studies have suggested that HCV could be a risk factor for COPD [18–20]. However, recent findings have suggested that HCV may not be a sole contributor to the increased prevalence of COPD [21]. So, the effect of HCV infection could be magnified in HIV/HCV coinfected patients [22].…”

Section: Introductionmentioning

confidence: 99%

Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)

et al. 2016

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PurposeThe aim of this study was to estimate trends of incidence of hospital admissions and in-hospital mortality (IHM) in HIV-infected patients with COPD in the combination antiretroviral therapy (cART) era in Spain (1997–2012).MethodsA retrospective study with data from nationwide population-based COPD diagnoses in the Spanish Minimum Basic Data Set (MBDS) was performed. We established groups according to their HIV and HCV infections: 1) HIV-uninfected patients; 2) HIV-infected patients (with or without HCV coinfection).Results1,580,207 patients discharge with a COPD diagnosis were included in the study, 8902 of them were HIV-infected patients (5000 HIV-monoinfected patients and 3902 HIV/HCV-coinfected patients). The HIV-infected patients had higher incidence rates of hospital admissions for COPD than the HIV-uninfected patients during the study period. The HIV-monoinfected patients had higher rates of hospitalizations for COPD than the HIV/HCV-coinfected patients in the early-period cART (1997–1999), but these rates decreased in the first group and increased in the second, being even similar in both groups in the late-period cART (2004–2011). On the other hand, the HIV-infected patients with COPD had higher IHM than the HIV-uninfected patients with COPD. The mortality rates were higher in the HIV-monoinfected patients with COPD than in the HIV/HCV-coinfected patients with COPD in the early-period cART; however, in the late-period cART, the mortality rates trends seems higher in the HIV/HCV group. The likelihood of death in HIV/HCV-coinfected patients with COPD was similar to than in HIV-monoinfected patients with COPD.ConclusionsIncidence of hospital admissions for COPD and IHM have decreased among HIV-monoinfected individuals but have increased steadily among HIV/HCV-coinfected individuals in the cART era.

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Hepatitis C Virus Infection Is Not An Independent Risk Factor For Obstructive Lung Disease

Cited by 10 publications

References 26 publications

COPD in HIV-Infected Patients: CD4 Cell Count Highly Correlated

COPD in HIV-Infected Patients: CD4 Cell Count Highly Correlated

Pulmonary disease in HIV-infected adults in the era of antiretroviral therapy

Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)

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