Hepatitis C virus infection prevalence in lichen planus: examination of lesional and normal skin of hepatitis C virus-infected patients with lichen planus for the presence of hepatitis C virus RNA

Erkek, Emel; Bozdogan, Ö.; Olut, Ali Ilgın

doi:10.1046/j.1365-2230.2001.00885.x

Cited by 42 publications

(38 citation statements)

References 27 publications

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“…These data are in open contrast with the data from other southern countries where HCV prevalence among OLP patients was as high as 25.7% (Italy) [6,8,29,41,54,55,57], 19.1% (Spain) [25,39,40,56] and 5.8% (Turkey) [35,37,42,44,48,49], respectively. Such HCV prevalence values are higher than the values reported for the general population in these countries, which range between 1 and 2.5% [11].…”

Section: Case-control Studycontrasting

confidence: 80%

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

et al. 2011

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Although hepatitis C virus (HCV) infection is associated with oral lichen planus (OLP), a case-control study and a meta-analysis were designed to investigate the magnitude of such an association. A total of 413 presumptive OLP patients (18-75 years) who referred to a dental clinic in Rasht (Iran) were consecutively selected. OLP was diagnosed clinically (typical forms) and histologically (atypical forms) by a calibrated examiner. A total of 487 adults (20-77 years) attending the same dental clinic were the controls. The two groups were homogeneous in terms of age, gender and occupation. Subjects were tested for anti-HCV antibodies. The odds ratio (OR) for OLP attributable to HCV infection was non-significant [OR 1.2, 95% confidence interval (95CI) 0.3-4.8], suggesting that the association between HCV and OLP was weak in the Iranian context. Meta-analysis of observational studies characteristics of primary studies were that cases were diagnosed clinically (only typical forms) and histologically and exposure was assessed through anti-HCV antibodies. Exposed/unexposed cases/controls were extracted and zero values were appropriately transformed. As much as 44 studies, including the present, were located. Publication bias could not be totally excluded. The pooled OR, estimated using the random-effect model, was 2.8 (95CI 2.4-3.2). Sensitivity analysis confirmed the robustness of results. Subgroup analysis showed non-significant differences between American/European and Asian/African studies. The fraction of global OLP cases associated with HCV (population attributable fraction) was 2.1% (95CI 1.9-2.2%). Although HCV and OLP were significantly associated, the majority of OLP patients were not affected by HCV.

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Section: Case-control Studycontrasting

confidence: 80%

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

et al. 2011

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“…In recent years, both mucosal and cutaneous lichen planus have been reported to occur in the setting of chronic HCV infection [14]. However, there are wide geographical variations in the reported prevalence of HCV infection in patients with LP, varying from 0% in England [16] to 63% in Japan [17].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a more widespread and chronic viral disease, hepatitis C (HCV), has been implicated in triggering LP. While some studies of selected populations with LP have confirmed a significant association with HCV [3,6-9], other investigations have failed to document this finding [10-14]. This study was conducted to determine the frequency of hepatitis C in patients with LP at Razi hospital, in Tehran, Iran.…”

Section: Introductionmentioning

confidence: 99%

Lichen planus and Hepatitis C: a case-control study

et al. 2004

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BackgroundThe association of lichen planus with hepatitis C (HCV) has been widely reported in the literature. However, there are wide geographical variations in the reported prevalence of HCV infection in patients with lichen planus. This study was conducted to determine the frequency of hepatitis C in Iranian patients with lichen planus at Razi hospital, Tehran.MethodsDuring the years 1997 and 1998, 146 cases of lichen planus, 78 (53.1%) women and 69 (46.9%) men were diagnosed. They were diagnosed on the basis of the usual clinical features and, if necessary, typical histological findings. The patients were screened for the presence of anti-HCV antibodies by third generation ELISA and liver function tests. We used the results from screening of blood donors for anti HCV (carried out by Iranian Blood Transfusion Organization) for comparison as the control group.ResultsAnti-HCV antibodies were detected in seven cases (4.8%). This was significantly higher than that of the blood donors' antibodies (p < 0.001). The odds ratio was 50.37(21.45–112.24). A statistically significant association was demonstrated between erosive lichen planus and HCV infection. Liver function tests were not significantly different between HCV infected and non-infected patients.ConclusionHCV apears to have an etiologic role for lichen planus in Iranian patients. On the other hand, liver function tests are not good screening means for HCV infection.

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“…However, in the study of Cribier et al (22) with 52 patients with LP, out of which 4 had oral localization, HCV prevalence was not found to be higher in LP patients than in patients with other type of dermatosis. In a study from Turkey, the prevalence of HCV infection was not found to be increased in Turkish patients with LP (23). However in another study from (J^ukurova region co-association of LP with HCV was found to be significant (24).…”

Section: Discussionmentioning

confidence: 88%

Cutaneous Manifestations in Patients Positive for Anti-Hepatitis C Virus Antibodies

Soylu¹,

Gül²,

Kılıç³

2007

Acta Derm Venereol

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Cutaneous diseases can indicate the presence of hepatitis C virus (HCV) infection. The aim of this study was to analyse the frequency of cutaneous findings in HCV infection and HCV RNA positive cases in Turkey. Fifty consecutive patients positive for anti-HCV antibodies,negative controls, and patients positive and negative for HCV RNA were examined for any cutaneous findings that could be associated with HCV infection. The risk of infected patients developing cutaneous finding was higher than for non-infected individuals. Only pruritus showed a statistically significant difference in separate assessment of cutaneous symptoms. There were no differences in cutaneous findings in HCV RNA positive and negative cases. The risk of developing a dermatological finding, especially pruritus, was increased in HCV infection.However, because the number of patients in this study was too low to allow statistical evaluation of the prevalence of dermatological symptoms and diseases, multicentre studies including large numbers of patients are needed.

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Hepatitis C virus infection prevalence in lichen planus: examination of lesional and normal skin of hepatitis C virus-infected patients with lichen planus for the presence of hepatitis C virus RNA

Cited by 42 publications

References 27 publications

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

Lichen planus and Hepatitis C: a case-control study

Cutaneous Manifestations in Patients Positive for Anti-Hepatitis C Virus Antibodies

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