Hepatitis C Virus Infections From a Contaminated Radiopharmaceutical Used in Myocardial Perfusion Studies

Patel, Priti R.; Larson, A. Kirsten; Castel, Amanda D.; Ganova-Raeva, Lilia; Myers, Robert A.; Roup, Brenda J.; Farrell, Katherine P.; Edwards, Leslie; Nainan, Omana V.; Krick, John P.; Blythe, David; Fiore, Anthony E.; Roche, Jeffrey C.

doi:10.1001/jama.296.16.2005

Cited by 65 publications

(33 citation statements)

References 31 publications

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“…Medical procedures associated with HCV infection are inevitable due to low compliance with universal precautions [104] including surgical procedures [114], gastrointestinal endoscopy [115], radiopharmaceuticals [116], and oncology procedures. Low compliance with universal precautions also contributed to hemodialysisassociated HCV infection [117].…”

Section: Prevention In Healthcare Settingsmentioning

confidence: 99%

APASL consensus statements and recommendations for hepatitis C prevention, epidemiology, and laboratory testing

et al. 2016

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The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on ''APASL consensus statements and recommendations for management of hepatitis C'' in March 2015 to revise the ''APASL consensus statements and management algorithms for hepatitis C virus infection'' (Hepatol Int 6:409-435, 2012). The working party consisted of expert hepatologists from the Asian-Pacific region gathered at the Istanbul Congress Center, Istanbul, Turkey on 13 March 2015. New data were presented, discussed, and debated during the course of drafting a revision. Participants of the consensus meeting assessed the quality of the cited studies. The finalized recommendations for hepatitis C prevention, epidemiology, and laboratory testing are presented in this review.

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Section: Prevention In Healthcare Settingsmentioning

confidence: 99%

APASL consensus statements and recommendations for hepatitis C prevention, epidemiology, and laboratory testing

et al. 2016

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“…116 Finally, there was a serious incident in which a number of patients were infected with Hepatitis C because of crosscontamination in the preparation of sestamibi using a saline container that had previously been handled as part of a cell labeling procedure. 117 This resulted from inadequate segregation of procedures and poor practice.…”

Section: Adverse Reactionsmentioning

confidence: 99%

Pitfalls and Limitations of SPECT, PET, and Therapeutic Radiopharmaceuticals

Ballinger

2015

Seminars in Nuclear Medicine

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“…As this procedure is now commonly performed at a commercial radiopharmacy offsite from the imaging center, the time between harvesting of the cells and reinjection into the patient is 3 to 4 hours. 18 Rare outbreaks of hepatitis C have been traced to radiopharmaceuticals contaminated at the time of preparation, 19 and the multiple transfers required by the complicated leukocyte labeling requires close adherence to proper aseptic techniques. Leukopenia may impair leukocyte harvesting, precluding the procedure in patients with white blood cell (WBC) counts below 2 Â10 6 cells/mL.…”

Section: Gallium-citratementioning

confidence: 99%

Nuclear Medicine Procedures in the Diagnosis of Orthopedic Infections

Rosenberg¹

2011

Techniques in Orthopaedics

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Nuclear medicine imaging procedures provide a unique physiological view of disease processes that may frequently precede anatomic changes visualized by other modalities. Orthopedic infections are particularly well served by these procedures because the presence of traumatic deformities or hardware in the musculoskeletal structures may significantly interfere with interpretation of images obtained using other modalities, such as computed tomography or magnetic resonance imaging. Several radiopharmaceuticals are currently available which can be imaged in either planar or tomographic formats. When appropriate, multiple radiopharmaceuticals can be imaged either sequentially or simultaneously to better clarify the disease process present in a particular patient. In addition to diagnosing active infection, some of these procedures can be used to follow the response to therapy, or to detect residual infection which may indicate further therapy is required. Newer hybrid imaging techniques which combine nuclear medicine procedures with anatomic imaging show great promise in better localizing infections, and in differentiating infection from noninfectious lesions such as arthritis. Nuclear medicine imaging procedures usually expose the patient to lower radiation doses than computed tomography, and are usually less expensive to perform than other modalities.Key Words: osteomyelitis-orthopedic infections-prosthesis infection-tagged leukocytes-bone gallium subtraction-three phase bone scan-positron emission tomography/computed tomography-single photon emission computed tomography/computed tomography. (Tech Orthop 2011;26: 271-289) N uclear medicine imaging procedures take advantage of the ability to image various radiopharmaceuticals injected into patients. A radiopharmaceutical is a drug that has a radioisotope attached to it in some manner. Radiopharmaceuticals may be molecules that have a radioactive atom incorporated into their structure, or may be complexes of molecules, including proteins, that are bound tightly to radioisotopes by mechanisms that are not always well understood. The clinically useful properties derive from the fact that the distribution of these radiopharmaceuticals in the body differs significantly in disease states compared with normal, and that the radioisotopes which are incorporated into them can be imaged by various detection devices.It is the altered physiology of disease states that nuclear medicine imaging procedures take advantage of. Although the spatial resolution of most nuclear medicine images is lower than other modalities, the latter most commonly image anatomy, whereas nuclear medicine images show physiology. A common nuclear medicine aphorism is that "physiology changes before anatomy." An example of this is a bone metastasis: the body's attempts at rebuilding bone invaded by malignancy are detected by 99m Tc-bisphosphonate uptake long before the demineralization caused by the metastasis can be detected by plain radiographs or computed tomography (CT). Before the availability of the...

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Hepatitis C Virus Infections From a Contaminated Radiopharmaceutical Used in Myocardial Perfusion Studies

Cited by 65 publications

References 31 publications

APASL consensus statements and recommendations for hepatitis C prevention, epidemiology, and laboratory testing

APASL consensus statements and recommendations for hepatitis C prevention, epidemiology, and laboratory testing

Pitfalls and Limitations of SPECT, PET, and Therapeutic Radiopharmaceuticals

Nuclear Medicine Procedures in the Diagnosis of Orthopedic Infections

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