Hepatitis C Virus‐related Lymphomas

Silvestri, Federico; Baccarani, Michele

doi:10.1046/j.1365-2141.1997.4023216.x

Cited by 65 publications

(49 citation statements)

References 44 publications

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“…However, the prevalence of HCV infection in B-cell NHL is variable as observed in various reported reviews. Two meta-analyses showed that the incidence of NHL and concurrent HCV infection range from 13% to 19.1% [10,11]. In some cases, there seems to be some geographic variance in the incidence of infection in NHL patients.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, lymphoplasmacytoid lymphoma is believed to be the most frequent histological subtype with concurrent HCV infection (26-49% of cases). Other subtypes that have been reported to have a high incidence of HCV infection include follicular center (8.6%), marginal zone (21.9%), and primary hepatosplenic lymphoma (71.4%) [11]. Also, extranodal involvement of lymphomas are more commonly seen in cases of HCV-related NHL than in non-HCV-related disease (65% vs. 19%), with involvement of the liver, GI mucosa (especially gastric MALToma), and salivary glands as the more common sites [8].…”

Section: Discussionmentioning

confidence: 99%

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Remission of natural-killer cell lymphoma of the liver with anti-hepatitis C therapy

Armor

Fazili

Toubia³

et al. 2005

Am. J. Hematol.

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Non-Hodgkin lymphomas (NHL) consist of a diverse group of lymphoproliferative neoplasms with unique patterns of biology, behavior, and differing responses to therapy. A rare subtype of malignancy arising from cells of putative natural killer (NK) origin is being recognized as a distinct clinicopathological entity. Viruses including hepatitis C have been reported in association with various types of NHL but not the NK-cell subtype. We hereby report a unique case of a patient with hepatitis C who developed hepatic NK-cell lymphoma and chronic NK-cell leukemia. Interestingly, we observed clinical and radiologic remission of the neoplasm following treatment with anti-hepatitis C therapy. Am.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Remission of natural-killer cell lymphoma of the liver with anti-hepatitis C therapy

Armor

Fazili

Toubia³

et al. 2005

Am. J. Hematol.

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“…In particular, lymphoplasmacytoid lymphoma/immunocytoma, the most frequent histological type among HCV-related lymphoma (26-49%), occurred more frequently in the studies from Italy. 1 Our HCV-positive cohort had an even distribution of low-, intermediate-, and high-grade lymphoma. However, the quota of patients with high grade lymphoma was very poor.…”

Section: To the Editormentioning

confidence: 99%

“…Regression of B cell expansion in HCV patients affected by cryoglobulinemia has also been reported in patients responsive to interferon therapy. 1 It has also been demonstrated that HCV is both a hepatotrophic and a lymphotrophic virus, and that the persistence of HCV stimulation in these cells may chronically cause a clonal expansion eventually resulting in malignant B cell lymphoproliferative diseases. Several Italian studies, 1 and more recently studies from North America 2 have postulated a direct relationship between HCV infection and the development of these tumors.…”

Section: To the Editormentioning

confidence: 99%

“…1 It has also been demonstrated that HCV is both a hepatotrophic and a lymphotrophic virus, and that the persistence of HCV stimulation in these cells may chronically cause a clonal expansion eventually resulting in malignant B cell lymphoproliferative diseases. Several Italian studies, 1 and more recently studies from North America 2 have postulated a direct relationship between HCV infection and the development of these tumors. The overall prevalence of HCV evaluated in 2274 B cell non Hodgkin lymphoma patients reviewed by Silvestri, is 19.1%, and in almost half of those analysed an association with the production of cryoglobulins was present.…”

Section: To the Editormentioning

confidence: 99%

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Hepatitis C virus infection in patients with B-cell lymphoproliferative disorders

Guida

D’Elia

Benvestito³

et al. 2002

Leukemia

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Hepatitis C virus infection and lymphoproliferative diseases in France: A national study

et al. 2000

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The putative role of hepatitis C virus (HCV) infection in the pathophysiology of lympho-proliferative diseases (LPD) is supported by North American and southern European studies reporting high HCV seroprevalence in patients with B-cell-non-Hodgkin lym-phoma (NHL). In order to evaluate the situation in France, we conducted a retrospective national study about the association of chronic HCV infection and LPD. 72 Internal Medicine and Infectious Diseases departments were contacted. Response rate was 51.4%. We recorded 43 LPD (19 males, 24 females): 31 B-cell-NHL, 4 Waldenströ m's macroglobulin-emia, 3 chronic lymphocytic leukemia, 2 multiple myeloma, 2 lymphomas of the mucosa-associated lymphoid tissue, and 1 Hodgkin's disease. Mean age at HCV diagnosis was 62 years (range 33-84). In 16 cases, LPD occurred in patients known to be HCV-infected. For 11 patients, LPD diagnosis preceded the diagnosis of HCV infection, whereas diagnosis was done simultaneously in 11 patients. For those with accurate infection date, mean interval between both events was 15.2 years. Fourteen patients had HCV extrahepatic manifestations: 9 mixed cryoglobulinemia, including 7 with NHL, 5 sicca syndrome (5 NHL), and both in one patient. Cohort of HCV-infected patients could be accurately determined for 16 departments, totaling 1,485 patients and 37 cases. Thus, from our data the frequency of LPD among HCV-infected patients approximates 2.49%. Despite possible bias inherent to this retrospective study, our data support the hypothesis of HCV-associated LPD and particularly B-cell-NHL. In France, this association is much lower than in Italy. Further studies are needed to assess the precise role of HCV in the multistep process leading to monoclonal proliferation. Am.

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Hepatitis C Virus‐related Lymphomas

Cited by 65 publications

References 44 publications

Remission of natural-killer cell lymphoma of the liver with anti-hepatitis C therapy

Remission of natural-killer cell lymphoma of the liver with anti-hepatitis C therapy

Hepatitis C virus infection in patients with B-cell lymphoproliferative disorders

Hepatitis C virus infection and lymphoproliferative diseases in France: A national study

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