Hepatitis C virus RNA dynamics during antiretroviral therapy

Bruno, Raffaele; Sacchi, Paolo; Filice, G.

doi:10.1182/blood.v97.10.3318

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…Others have argued that HCV treatment should be undertaken first, since HAART may in fact increase HCV load, cause hepatotoxicity, and interact with HCV medications in a manner that may limit compliance (3). The data in our study support, in part, both arguments.…”

Section: Discussionsupporting

confidence: 79%

Impact of Highly Active Antiretroviral Therapy and Immunologic Status on Hepatitis C Virus Quasispecies Diversity in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Patients

Babik

Holodniy

2003

J Virol

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This study analyzes the effect of highly active antiretroviral therapy (HAART), and thus immunologic status, on hepatitis C virus (HCV) load and quasispecies diversity in patients coinfected with the human immunodeficiency virus (HIV) and HCV. Three cohorts of coinfected patients were analyzed retrospectively over a period of 7 to 10 months: group A was antiretroviral drug naïve at baseline and then on HAART for the remainder of the study, group B did not receive antiretroviral therapy at any point, and group C was on HAART for the entire study. HCV quasispecies diversity was analyzed by sequencing hypervariable region 1. In a longitudinal analysis, there was no significant change from baseline in any immunologic, virologic, or quasispecies parameter in any of the three groups. However, in comparison to groups A and B, group C had significantly higher CD4؉ -and CD8 ؉ -cell counts, a trend toward a higher HCV load, and significantly increased number of HCV clones, entropy, genetic distance, and ratio of nonsynonymous substitutions per nonsynonymous site to synonymous substitutions per synonymous site (K a /K s ). In addition, CD4؉ -cell count was positively correlated with HCV load, genetic distance, and K a . Interestingly, patients infected with HCV genotype 2 or 3 had a significantly higher CD4؉ -cell count, HCV load, genetic distance, and K a /K s than those infected with genotype 1. These results suggest that there is no immediate effect of HAART on HCV but that, with prolonged HAART, immune restoration results in an increase in HCV load and quasispecies diversity.

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Section: Discussionsupporting

confidence: 79%

Impact of Highly Active Antiretroviral Therapy and Immunologic Status on Hepatitis C Virus Quasispecies Diversity in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Patients

Babik

Holodniy

2003

J Virol

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HIV and Hepatitis C Virus: Facts and Controversies

et al. 2003

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Hepatitis C virus (HCV) infection occurs in about one-third of HIV-seropositive patients and in about 90% of HIVpositive drug abusers. After the introduction of highly active antiretroviral therapy (HAART) and the subsequent reduction in mortality from opportunistic infections, HCV-related liver failure has become a frequent cause of death in HIV-positive patients. In HIV-seropositive patients, the course of HCV infection is accelerated and there is evidence that HCV is an important factor for HIV progression. Consequently, it is important to establish the appropriate treatment for HCV infection in HIV-seropositive patients. This review examines the epidemiology, physiopathology, diagnostics and treatment of HIV/HCV coinfection with particular regard to the impact of HAART.

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