Hepatitis C virus serotype II responds more favorably to interferon-α therapy

Orito, Etsuro; Mizokami, Masashi; Mizoguchi, Naoto; Ohba, Ken‐ichi; Tohnai, Miyako; Yamanaka, H; Oguri, Tetsuya; Hirashima, Noboru; Koide, Tsuneo; Kano, Hideyuki; Tsukiyama-Kohara, Kyoko; Kohara, Michinori; Lau, Johnson Y.N.

doi:10.1016/s0168-8278(94)80149-5

Cited by 28 publications

(10 citation statements)

References 8 publications

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“…Improved responses are found in those patients infected with HCV 2118 155 or HCV 2 and 3 compared with patients infected with genotype 1 117. In a review of 15 IFN trials, sustained response was seen in 18.1% of HCV 1 infected patients compared with 54.9% of patients infected with other genotypes 156.…”

Section: 0 Treatmentmentioning

confidence: 99%

Clinical guidelines on the management of hepatitis C

Booth¹,

O’Grady²,

Neuberger³

2001

Gut

137

116

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Section: 0 Treatmentmentioning

confidence: 99%

Clinical guidelines on the management of hepatitis C

Booth¹,

O’Grady²,

Neuberger³

2001

Gut

137

116

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“…Human hepatitis C virus (HCV) was divided into 4 genogroups, and IFN is more effective for Genotypes III and IV, whereas IFN is ineffective for many strains in Genotype II (Orito et al 1994). In FCV, moderately and high-sensitive strains accounted for 77%, showing that the effect does not markedly vary among the genogroups, unlike HCV.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity of FCV to recombinant feline interferon (rFeIFN)

et al. 2007

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Feline calicivirus cause feline respiratory diseases, and inactivated and attenuated vaccines are available for its prevention. Moreover, the presence of vaccine breakdown strains (VBS) is problematic. In Japan, feline recombinant interferon (rFeIFN) has been used for its treatment. However the method of compare with each strains has not established. To examine the relationship between the breakdown vaccine strain and rFeIFN sensitivity, the sensitivity of 47 field isolates to rFeIFN was determined. The Log PDD(50) values were normally distributed within the range 1.1-3.7, with a mean value of 2.3 +/- 0.64. Since 68.3% of the PDD values fell in the range of the mean +/- standard deviation, the values in the range 1.7-2.9, the lower values, and the higher values were defined as representing moderate, low, and high sensitivity, respectively. Among the 15 vaccine breakdown strains, strain Fukuoka9 showed a low sensitivity, but strains ML89, T58, and N74 were highly sensitive, showing no association with vaccine breakdown. The amino acid sequence changes specific to the low rFeIFN-sensitive Fukuoka-9 strain were found, suggesting that these sites are involved in rFeIFN sensitivity.

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“…With respect to HCV genotypes, the patients with HCV genotype 2 have a greater tendency to lose HCV RNA by IFN therapy than do those with other genotypes [Orito et al, 1994]. However, it has been reported that the natural course of HCV infection does not depend upon genotypes [Inoue et al, 2000].…”

Section: Discussionmentioning

confidence: 99%

Loss of hepatitis C virus RNA after parturition in female patients with chronic HCV infection

Hattori

Orito

Ohno

et al. 2003

Journal of Medical Virology

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It is unclear whether pregnancy has any influence on chronic hepatitis C virus (HCV) infection. The aim of this study was to investigate the relationship between pregnancy and parturition with HCV viremia levels and the natural resolution of HCV RNA. Twenty-two pregnant patients and 120 nonpregnant control female patients, both positive for anti-HCV and HCV RNA, were studied. The HCV core protein levels were quantified by enzyme immunoassay, and HCV RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR). Of the pregnant group, two females whose HCV RNA was negative continuously for more than 6 months lost HCV RNA permanently after parturition, and one female whose level of HCV core protein was intermittently under the limit of detection level lost HCV RNA intermittently. In the control group, only one female lost HCV RNA persistently, and one lost HCV RNA intermittently after she developed liver cirrhosis. At 3 months after parturition, the HCV core protein level was <15 fmol/L in all patients who lost HCV RNA, while the HCV core protein level was >/=15 fmol/L in 81.3% of the patients who persistently had HCV RNA (P = 0.03). Significantly more pregnant patients lost HCV RNA than did nonpregnant controls. These findings suggest that pregnancy and parturition appear to influence the clinical course of HCV infection.

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Hepatitis C virus serotype II responds more favorably to interferon-α therapy

Cited by 28 publications

References 8 publications

Clinical guidelines on the management of hepatitis C

Clinical guidelines on the management of hepatitis C

Sensitivity of FCV to recombinant feline interferon (rFeIFN)

Loss of hepatitis C virus RNA after parturition in female patients with chronic HCV infection

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