Hepatitis C virus transmission and its risk factors within families of patients infected with hepatitis C virus in southern Iran: Khuzestan

Hajiani, Eskandar; Masjedizadeh, Rahim; Hashemi, Jalal; Azmi, Mehrdad; Rajabi, Tahereh

doi:10.3748/wjg.v12.i43.7025

Cited by 45 publications

(25 citation statements)

References 19 publications

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“…Intrafamilial transmission of HCV is considered as a nonsignificant route of transmission, and sexual transmission does not seem to play a role in the intrafamilial spread of HCV infection 18,19 . However, same studies have demonstrated significant anti-HCV prevalence rates in family members of patients with chronic HCV and/or in household contacts of anti-HCV-positive individuals 20 .…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B and C virus infection among Brazilian Amazon riparians

Oliveira

Silva

Santos

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Viral hepatitis is a major public health concern in Brazil. There are few past studies on this issue, especially among riparian communities. This study aims at determining the seroprevalence of viral hepatitis B and C in the riparian community of Pacuí Island, within the Cametá municipality of Pará State, Brazil. Moreover, this study aims to investigate the principal risk factors that this community is exposed to. Methods: The current study has accessed blood samples from 181 volunteers who have answered an epidemiological questionnaire. Analyses on serological markers have been tested with commercial ELISA kits for detecting HBsAg, total anti-HBc, anti-HBs, and anti-HCV. Within seroreactive patients for HCV, RT-PCR and line probe assay have been performed to identify the viral genotype. Results: In the serological marker analysis for hepatitis B, no reactivity for HBsAg, rate of 1.1% for total anti-HBc, and rate of 19.3% for anti-HBs have been observed. On hepatitis C, 8.8% seroprevalence has been found, in which 62.5% have gotten viral RNA. Among the risk factors studied, the following have been highlighted: non-use of condoms, sharing of cutting instruments, use of illicit drugs, and reports of family disease with HBV or HCV. Conclusions: The vaccination coverage against HBV is low, and the high prevalence of HCV within this community has been observed.

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Section: Discussionmentioning

confidence: 99%

Hepatitis B and C virus infection among Brazilian Amazon riparians

Oliveira

Silva

Santos

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…6 On the other hand, according to some other published data, the prevalence of HCV infection in Iran is 0.59% to 0.8%. 7 Moreover, HCV infection among Iranian prisoners is high, despite low HCV seroprevalence in the general population. 8 According to some reports, up to 40% of Iranian prisoners who are intravenous drug users (IDUs or IVDAs) are positive for anti-HCV antibody (Ab).…”

Section: Hepatitis Cmentioning

confidence: 99%

Seroprevalence of and Risk Factors Associated With Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus Among Prisoners in Iran

Pourahmad¹,

Javady²,

Karimi³

et al. 2007

Infectious Diseases in Clinical Practice

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“…This infection is a virulent health problem affecting more than 170 million people worldwide. The prevalence rate of HCV infection is from 0.2 up to 40% in different countries (2, 3) (about 0.2 to 2.2% in developed countries and nearly 7% in developing countries) (4). The prevalence of HCV infection is less than 0.5% (0.1% in women and 1.0% in men) in the general population of Iran (5) and this infection is common in hemophilia, thalasemia, hemodialysis patients and in intravenous drug users (IVDU) (6, 7).…”

Section: Introductionmentioning

confidence: 99%

Distribution of Hepatitis C Virus Genotypes in Iranian Chronic Infected Patients

et al. 2013

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BackgroundHepatitis C virus (HCV) has different genotypes throughout the world. Since the determination of which antiviral treatment to be applied is related to HCV genotypes, identification of an individual’s HCV genotypes prior to antiviral therapy is critical.ObjectivesThe purpose of this study was to investigate the distribution of HCV genotypes in a large population of Iranian HCV infected patients.Patients and MethodsEleven thousand, five hundred and sixty one patients with chronic HCV infection which referred to hospitals related to the Tehran University of Medical Sciences and Tehran Hepatitis Center-Clinical Department of Baqiyatallah Research Center for Gastroeneterology and Liver Disease from March 2003 to December 2011 were enrolled. Following extraction of viral RNA of the serum, HCV-RNA was detected using reverse transcriptase-nested polymerase chain reaction (RT-nested PCR) and then HCV genotypes analyzed by restriction fragment length polymorphism (RFLP) assay.ResultsThe mean age of patients was 37.6 ± 14.2 years (range: 1-87). The highest frequency was noted for subtype 1a (44.9%) followed by subtype 3a (39.6%), and 1b (11.3%). Mixed HCV genotypes were also found in 2.5% of the total cases. Subtype 1a was the most frequent genotype in patients over 40 years of age (46.1% versus 42.4%) and subtype 3a was the most frequent in patients under 40 years old (41.5% versus 38.9%).ConclusionsThis study suggested that the dominant HCV subtype among Iranian patients was 1a followed by subtype 3a.

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Hepatitis C virus transmission and its risk factors within families of patients infected with hepatitis C virus in southern Iran: Khuzestan

Abstract: Intrafamilial transmission of HCV is not the significant transmission route and sexual transmission does not seem to play a role in the intrafamilial spread of HCV infection. Intrafamilial transmission of HCV is possible but occurs at a low rate.

Cited by 45 publications

References 19 publications

Hepatitis B and C virus infection among Brazilian Amazon riparians

Hepatitis B and C virus infection among Brazilian Amazon riparians

Seroprevalence of and Risk Factors Associated With Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus Among Prisoners in Iran

Distribution of Hepatitis C Virus Genotypes in Iranian Chronic Infected Patients

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