Hepatitis C-Z: recent advances

Kelly, Déirdre; Skidmore, Susan J.

doi:10.1136/adc.86.5.339

Cited by 23 publications

(8 citation statements)

References 72 publications

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“…This is in agreement with Kumar et al (2009), Kaplowitz (2004, Kelly and Skidmore (2002), Basu (2003), Manibusan, Odin and Eastmond (2007) and Planaguma et al (2005) who reported significant increase in the enzyme activity on administration of CCl 4 . The reduction of the ALT, AST and ALP values decreased with increase in dose of neem oil when compared with the CCl 4 group only.…”

Section: Discussionsupporting

confidence: 93%

Protective effects of neem (<i>Azadirachta indica A. Juss</i>) seed oil on carbon tetrachloride-induced hepatotoxicity in Wistar rats

Idu¹,

Oghale²,

Okojie³

2017

JOMPED

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Background: Azadirachta indica (neem) seed oil was evaluated for its hepatoprotective effect. Liver damage was induced using carbon tetrachloride (CCl4) while silymarin served as a positive control.Aim: This study is aimed at testing the hepatoprotective potentials of A. indica seed oil on Wistar rats.Method: Hepatotoxicity was induced by the administration of 1.0 mL/kg of CCl4 subcutaneously to 72 healthy Wistar rats of both sexes (weight range: 145 g – 315 g). The seed oil of A. indica was orally administered daily in various doses of 0.25 mL/kg, 0.5 mL/kg and 1.0 mL/kg for 14 days. Animal body and organ weights were recorded, while blood and liver tissues were collected for biochemical, haematological and histological analyses.Results: Treatment with neem seed oil lowered the aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels significantly (P < 0.05) in a dose-dependent manner compared to the control. The haematological parameters, organ weight index and animal body weight showed no significant difference (P > 0.05) when compared with the control. Histology assessment was in agreement with the biochemical result as tissues of CCl4 exhibited significant fatty tissue accumulation, as opposed to that of 0.25 mL/kg neem treatment, which showed only moderate accumulation of fatty tissues, while higher doses, 0.5 mL/kg and 1.0 mL/kg, showed a healthy liver as compared with the control.Conclusion: The result of this study revealed that neem seed oil had a dose-dependent hepatoprotective effect on the experimental rats.

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Section: Discussionsupporting

confidence: 93%

Protective effects of neem (<i>Azadirachta indica A. Juss</i>) seed oil on carbon tetrachloride-induced hepatotoxicity in Wistar rats

Idu¹,

Oghale²,

Okojie³

2017

JOMPED

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“…Several studies of pediatric HCV cohorts suggest that HCV infection follows a benign course of disease (2–4), yet other studies have shown a more aggressive clinical course in pediatric HCV populations (3, 5–11). In addition, pediatric patients with HCV remain a vulnerable population because of the limited knowledge available on the progression of the disease (12). …”

Section: Introductionmentioning

confidence: 99%

Symptomatic and Pathophysiologic Predictors of Hepatitis C Virus Progression in Pediatric Patients

Henderson¹,

Shankar²,

Feld³

et al. 2009

Pediatric Infectious Disease Journal

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“…HCV (hepatitis C virus) infection occurs less frequently in children than in adult patients. The natural history, prognosis and clinical significance of HCV infection are poorly defined in childhood [ 11 ]; in contrast, HCV infection in adults presents a high degree of chronicity, with up to 50% of all HCV-infected adults developing progressive liver disease [ 21 ]. Results from prospective studies show that 20–30% of chronically infected adults develop compensated and eventually decompensated cirrhosis or hepatocellular carcinoma, or both, within 20 years of the initial infection [ 1 ].…”

Section: Introductionmentioning

confidence: 99%