Hepatitis D infection in Brazil: prevalence and geographical distribution of anti-Delta antibody

Lago, Bárbara Vieira do; Mello, Francisco Campello do Amaral; Barros, Tairine M; Mello, Vinicius M.; Villar, Lívia Melo; Lewis‐Ximenez, Lia Laura; Pardini, Maria Inês M. C.; Lampe, Elisabeth

doi:10.1002/jmv.25088

Cited by 2 publications

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“…In a similar manner, migrants from Equatorial Guinea in Spain presented high rates of HDV seropositivity (24%) 28. The same pattern of HDV hyperendemicity is observed in adjacent regions of Brazil, Peru and Colombia, corresponding to the peri-equatorial and forested areas of the Amazon basin 29–32. There is no known explanation for the increased HDV prevalence observed in these regions.…”

Section: Discussionmentioning

confidence: 73%

The epidemiology of hepatitis delta virus infection in Cameroon

Besombes

Njouom

Paireau

et al. 2020

Gut

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ObjectiveTo investigate the distribution and risk factors of hepatitis delta virus (HDV) infection in Cameroon.DesignWe tested for hepatitis B virus (HBV) surface antigen (HBsAg) and anti-HDV antibody 14 150 samples collected during a survey whose participants were representative of the Cameroonian adult population. The samples had already been tested for hepatitis C virus and HIV antibodies.ResultsOverall, 1621/14 150 (weighted prevalence=11.9%) participants were HBsAg positive, among whom 224/1621 (10.6%) were anti-HDV positive. In 2011, the estimated numbers of HBsAg positive and HDV seropositives were 1 160 799 and 122 910 in the 15–49 years age group, respectively. There were substantial regional variations in prevalence of chronic HBV infection, but even more so for HDV (from 1% to 54%). In multivariable analysis, HDV seropositivity was independently associated with living with an HDV-seropositive person (OR=8.80; 95% CI: 3.23 to 24.0), being HIV infected (OR=2.82; 95% CI: 1.32 to 6.02) and living in the South (latitude <4°N) while having rural/outdoor work (OR=15.2; 95% CI: 8.35 to 27.6, when compared with living on latitude ≥4°N and not having rural/outdoor work).ConclusionWe found evidence for effective intra-household transmission of HDV in Cameroon. We also identified large differences in prevalence between regions, with cases concentrated in forested areas close to the Equator, as described in other tropical areas. The reasons underlying these geographical variations in HDV prevalence deserve further investigation.

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Section: Discussionmentioning

confidence: 73%

The epidemiology of hepatitis delta virus infection in Cameroon

Besombes

Njouom

Paireau

et al. 2020

Gut

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“…14 Similarly, in Brazil, the highest concentration of HDV patients is found in the Amazon basin compared to the rest of the country. 19…”

Section: Mongolia Andmentioning

confidence: 99%

The medical impact of hepatitis D virus infection in Asia and Africa; time for a reappraisal

Rizzetto

Salehiniya

2020

Liver International

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Although hepatitis D is believed to be an important medical problem in Africa and many areas of Asia, the geographical distribution and prevalence rates of infection with the hepatitis D virus (HDV) vary considerably, are often inconsistent and sometimes conflicting. Discrepancies may depend on methodological problems, primarily on different modalities of patients' recruitment; these are analysed in this mini-review, in order to provide a uniform clinical approach when testing patients with chronic HDV disease. K E Y W O R D S hepatitis D, hepatitis D virus, hepatitis delta How to cite this article: Rizzetto M, Hamid S. The medical impact of hepatitis D virus infection in Asia and Africa; time for a reappraisal.

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Hepatitis D infection in Brazil: prevalence and geographical distribution of anti-Delta antibody

Cited by 2 publications

References 0 publications

The epidemiology of hepatitis delta virus infection in Cameroon

The epidemiology of hepatitis delta virus infection in Cameroon

The medical impact of hepatitis D virus infection in Asia and Africa; time for a reappraisal

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