Hepatitis E

Purdy, Michael A.; Krawczynski, Krzysztof

doi:10.1016/s0889-8553(21)00152-7

Cited by 18 publications

(2 citation statements)

References 46 publications

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“…"HEV infection is an enterically transmitted liver disease that is typically self-limited [6,7], but it can trigger fulminant hepatitis in pregnant women where it causes 20-25% mortality" [8]. "Infection with HEV can also progress and become either rapidly fatal or chronic in immunosuppressed individuals" [9].…”

Section: Introductionmentioning

confidence: 99%

Aggravating Effects of Hepatitis E Virus Infection on Patients with Chronic Liver Disease in Ibn-Sina Hospital Sudan

Ismail,

Enan,

El-Hussein

et al. 2023

AJRID

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Background: Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis. Sudan is considered as hyper-endemic for HEV. HEV infection in patients with preexisting chronic liver diseases (CLDs) has been reported to result in severe clinical manifestations and poor outcomes. However data on the role of HEV infection in worsening of pre-existing CLD are limited. Objective: To determine hepatitis E virus (HEV) infection and its effect on severity of CLD. Methods: A descriptive cross-sectional study that consecutively enrolled 87 CLD patients in Ibn-Sina Specialized Hospital was carried out during the period from August 2020 to December 2020. Data regarding demographics, CLD causes, clinical manifestations and comorbidities were collected. The screening for anti-HEV antibodies was performed in all patients by using enzyme linked immuno-sorbent assay (ELISA). Results: Hepatitis B virus (HBV) was the commonest etiology of chronic liver diseases being detected in 45/87(51.7%) patients. On the other hand;among all subjects; 43/87(49.4%) patients were HEV seropositive with anti-HEV Ig-G being detected in 32(36.8%) and concurrent anti-HEV Ig-M and Ig-G in 11(12.6%) patients. Jaundice (OR= 3.8, CI95%: 1.5-9.4; P. value=0.004), HCC (OR= 4.1, CI95%: 1.4-11.9; P. value=0.008), child-Pugh class-C (OR= 26, CI95%: 5.4-94.0; P. value=0.000) and child-Pugh class-B (OR= 5.3, CI95%: 1.6-17.0; P. value=0.000) were associated independently with anti-HEV positivity. Conclusion: The frequency of hepatitis E virus (HEV) among Sudanese patients with chronic liver disease (CLD) was considerably high (mainly past infection- Ig-G). Furthermore, HEV was associated with advanced liver failure statuses (child-Pugh class-B & C), jaundice, and hepatocellular carcinoma.

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Section: Introductionmentioning

confidence: 99%

Aggravating Effects of Hepatitis E Virus Infection on Patients with Chronic Liver Disease in Ibn-Sina Hospital Sudan

Ismail,

Enan,

El-Hussein

et al. 2023

AJRID

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“…Data from Pakistan showed that samples obtained from sewerage water in Rawalpindi and Islamabad discovering 40. 7% of the sewerage samples to be contaminated with HEV [1,2]. HEV has eight genotypes.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Cholestasis Among the Patients Suffering from Hepatitis E Virus

Shahid¹,

Ali²,

Hamid³

2022

PJMHS

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Introduction: Acute viral hepatitis (AVH) is a major health concern in developing nations in regard to morbidity and mortality. Cholestasis in the form of bile thrombi in canaliculi is common in acute hepatitis but rare in chronic hepatitis This study was designed to find the influence of cholestasis among the patients suffering from hepatitis E virus. The aim of this study was to determine the frequency of cholestasis among the patients suffering from viral hepatitis E. Methods: The design of this study was Descriptive Cross-Sectional Study design, and the duration of this study was from 30 January 2022 to 20 September 2022 at Department of Gastroenterology Sheikh Zayed Hospital Lahore. A total of 189 patients were enrolled were observed to determine the frequency of cholestasis among the patients suffering from viral hepatitis E. Consecutive non-probability sampling technique was ___ used to collect data from the patients. All the collected data were entered and analyzed into SPSS version 24. Data were stratified for age, gender and history of diabetes. Post stratification Chi-square test were applied taking p value of <0. 05 as statistically significant. Results: Age wise distribution among 189 patients were analyzed as n= 15-20 Years 11(5. 8%) 21-30 Years 13(6. 9%) 31-40 Years 45(23. 8%)41-50 Years 86(45. 5%) 51-60 Years16(8. 5%) 61-70 Years18(9. 5%). Mean age was 47. 95 years+ 14. 176 SD. Gender wise distribution among 189 patients were analyzed as n= Male was110(58. 2%) Female was 79(41. 8%). Duration of Disease among 189 patients were analyzed as n= Less than 3 months was 103(54. 5%) and more than 3 months was 86(45. 5%). History of diabetes among 189 patients were analyzed as n= Yes was found 94(49. 7%) and No was found 95(50. 3%). Distribution of cholestasis among 189 patients were analyzed as n= Yes was found 90 (47. 6%) and No was found 99(52. 4%). Conclusion: Based on our findings, the prevalence of cholestasis was 49. 7% is in the range of that found in general population. However, this is an evolving area with ongoing research and further assessments in prospective large studies are warranted. It is not possible to differentiate viral hepatitis based on clinical features, biochemical parameters, and severity of illness. Serological markers are essential for correct etiological diagnosis. However, cholestasis is found to be significantly associated with hepatitis-E infection. Keywords: cholestasis, viral hepatitis E, infection, ELISA

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Risk Assessment of Environmental Exposure to Viruses

Mena

2003

Encyclopedia of Environmental Microbiology

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Hepatitis E

Cited by 18 publications

References 46 publications

Aggravating Effects of Hepatitis E Virus Infection on Patients with Chronic Liver Disease in Ibn-Sina Hospital Sudan

Aggravating Effects of Hepatitis E Virus Infection on Patients with Chronic Liver Disease in Ibn-Sina Hospital Sudan

Frequency of Cholestasis Among the Patients Suffering from Hepatitis E Virus

Risk Assessment of Environmental Exposure to Viruses

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