Hepatitis E virus infection and risk of hepatocellular carcinoma: A systematic review and meta-analysis

Hepatitis E virus infection upregulates ING5 expression invitroandvivo

“…HEV infection causes a self-limiting disease, but acute liver failure or fulminant hepatic failure were occurred in HEV-infected pregnant women [3, 4]. HEV infection is associated with chronic hepatitis and liver cirrhosis, and increases the risk of HCC [29]. However, the relationship between HEV and HCC was rarely reported, and the role of HEV in developing HCC is unclear.…”

Immunological pathways in viral hepatitis-induced hepato-cellular carcinoma

“…同时，不同的肝炎病毒感染导致肝细胞癌发生的过程也存在一些差异。如在HBV感染患者中，肝细胞癌也可以发生于不存在肝硬化或明显炎症的慢性肝病患者中，这表明HBV感染有直接致癌作用 ［ 23 ］ 。然而，在HCV感染者中，如果不伴有重度肝纤维化，则肝细胞癌很少发生 ［ 46 ］ 。此外，相较于其他肝炎病毒，HCV还可导致脂肪性肝炎，从而加速肝纤维化和肝硬化的进程 ［ 58 - 59 ］ 。HEV在器官移植和获得性免疫缺陷综合征等免疫缺陷人群中的慢性感染是其特殊的临床问题 ［ 71 - 72 ］ 。尽管鲜有HEV感染导致细胞增殖和凋亡相关的细胞信号通路激活从而诱导肝细胞癌发生的报道，已有流行病学和临床研究提示HEV慢性感染可能是导致肝细胞癌发生的因素之一 ［ 73 ］ 。…”