Hepatitis E virus infection in HIV‐infected patients: A large cohort study in Yunnan province, China

Zhou, Shi-Yi; Ren, Li; Xia, Xueshan; Miao, Zhijiang; Huang, Fen; Li, Yunlong; Zhu, Mingzhao; Xie, Zhenrong; Xu, Yü; Qian, Yuan; Pan, Qiuwei; Wang, Kunhua

doi:10.1002/jmv.25060

Cited by 14 publications

(11 citation statements)

References 33 publications

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“…The majority of these studies found a similar HEV seroprevalence between patients with a CD4+ cell count that was either higher or lower than 200 cells/mL (Kaba et al, 2011; Kenfak-Foguena et al, 2011; Jardi et al, 2012; Pineda et al, 2014; Bura et al, 2017b; Ferreira et al, 2018), or when a cut-off of 250 cells/mm 3 was applied (Zeng et al, 2017). Nevertheless, there are studies that found a higher HEV seroprevalence in patients with a total CD4+ cell count higher than 200 cells/mL (Kenfak-Foguena et al, 2011), while other studies found the opposite effect, in that patients with a CD4+ count below 200 cells/mL showed a higher seroprevalence of IgG antibodies (Renou et al, 2010; Debes et al, 2016; Zhou et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, one outbreak, which was linked to the consumption of wild boar meat in Spain, that involved HIV-infected patients has been recently reported (Rivero-Juarez et al, 2017c). Other factors associated with HEV seroprevalence in the general population, such as older age (Feldt et al, 2013; Rapicetta et al, 2013; Pineda et al, 2014; Rivero-Juarez et al, 2015b; Shrestha et al, 2017; Zeng et al, 2017; Zhou et al, 2018), geographical location or habitat (Renou et al, 2010; Feldt et al, 2013; Rapicetta et al, 2013; Junaid et al, 2014; Scotto et al, 2014; Yong et al, 2014; Rivero-Juarez et al, 2017a; Shrestha et al, 2017; Zeng et al, 2017), and male sex (Pineda et al, 2014; Zeng et al, 2017; Boon et al, 2018), have also been associated with HIV-infected patients. Consequently, the main route of HEV, including all viral genotypes, does not differ between the general and HIV populations.…”

Section: Resultsmentioning

confidence: 99%

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Hepatitis E Infection in HIV-Infected Patients

2019

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Background The hepatitis E virus (HEV) represents a major cause of acute hepatitis worldwide. The majority of HEV cases occur in low-income countries, mainly Asia and Africa, where HEV causes large outbreaks associated with the consumption of contaminated water and high mortality in specific populations. In high-income countries, HEV infection is considered a zoonotic disease that is linked to the consumption of contaminated food. Although a high proportion of cases have self-limiting asymptomatic or subclinical infections, immunosuppression may modify the pathogenesis and clinical impact of this emerging disease. Results and Discussion Here, we review the current knowledge about the epidemiology, diagnosis, clinical manifestations, management and prevention of HEV infection in HIV-infected subjects. Conclusions Despite the increasing knowledge about the pathogenesis, epidemiology and clinical impact of HEV infection, several major factors are faced by HIV-infected patients, including treatment recommendations, immunization and risk practices.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hepatitis E Infection in HIV-Infected Patients

2019

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“…Levels of CD4+ T-cells in peripheral blood seem to be the most widely associated risk factor for HEV infection in HIV-infected patients 6,23,24 , although there are also articles that this association does not find 25 . The CD4+ T-cell counts reflect the level of immune suppression; and when CD4+ T-cells fall below 350 cells/μL, the risk of death, AIDS, and/or non-AIDS-defining conditions increases 26–29 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012–2014)

Vázquez-Morón

Berenguer

González-García

et al. 2019

Sci Rep

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Hepatitis E virus (HEV) has emerged as a relevant pathogen for HIV-infected patients. However, there is scarce data on HEV infection in HIV/HCV-coinfected individuals with advanced fibrosis, which seems to increase the risk of HEV infection and worsen the prognosis of liver disease. We aimed to determine the prevalence of anti-HEV antibodies, acute hepatitis E, resolved hepatitis E, and exposure to HEV in HIV/HCV-coinfected patients and to evaluate associations with clinical and epidemiological characteristics. We performed a cross-sectional study on 198 HIV/HCV-coinfected patients, 30 healthy controls and 36 HIV-monoinfected patients. We found a low concordance between techniques used for detection of anti-HEV antibodies (ELISA versus Immunoblot), particularly in HIV/HCV-coinfected patients. HIV/HCV-coinfected patients showed the highest prevalence of IgG against HEV, resolved hepatitis E, and exposure to HEV (19.2%, 17.2%, and 22.2% respectively). However, we did not find any samples positive for HEV-RNA nor significant differences between groups. Moreover, HIV/HCV-coinfected patients with CD4 T-cells <350 cells/mm3 had higher prevalence for anti-HEV IgG antibodies, resolved hepatitis E, and exposure to HEV than healthy controls or those with CD4 T-cells ≥ 350 cells/mm3 (p = 0.034, p = 0.035, and p = 0.053; respectively). In conclusion, HIV/HCV-coinfected patients in Spain have a high prevalence for IgG anti-HEV antibodies, resolved hepatitis E, and exposure to HEV; particularly patients with CD4+T-cells <350 cells/mm3.

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“…Over all rate of HEV among the HIV patients in China were 44.68% and the anti-HEV prevalence expanded by 4.1% every year with patient's age. Beside age the other factors such as gender, CD4 cell count, WHO stage, marital status and total cholesterol levels are other risk factors that are associated with HEV co-infection in HIV-infected population 90 . Another investigation from China additionally detailed the HEV among disease patients and the rate was 26.0% and the highest HEV seropervalence occurred in patients with leukemia followed by liver and gastric cancer.…”

Section: Cases Related To High Risk Patientsmentioning

confidence: 99%

Hepatitis E: Current Status in India and Other Asian Countries

Kumar¹,

Kamar²,

Kumar³

2019

J Pure Appl Microbiol

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Six types of hepatitis infections are accounted for the inflammation of liver in human throughout the world and assigned the letter A, B, C, D, E and G. Out of these, Hepatitis E, caused by Hepatitis E virus (HEV), currently categorized as a member of the genus Hepevirus in the family Hepeviridae. Hepatitis E is considered highly significant, on account of its predominance in both developed and developing nations, due to poor sanitation and cleanliness condition related to drinking water. This review focuses on general epidemiological study update of hepatitis E virus in India and rest of Asia for the selected period and also throws light on some diagnostic approaches available for the same. An extensive literature search was performed with published work and search in PubMed using term "HEV" combined with "country name" restricting the search publication between year 2008 to 2018 for India and 2013 to 2018 for the rest of Asia. The data was analyzed in detail to meet the requirements of the objectives. Study showed that in India the major causes of Hepatitis E was water contaminated with fecal matter. Reports from East and Southeast Asia signified the role of animal reservoir especially the pigs for HEV. Whereas in Indian neighboring countries like Nepal, Pakistan and Western Asia the major cases of Hepatitis E were associated with blood transfusion and pregnancy related cases. Majority of the diagnostic approaches used in India at medical facilities are based on anti-HEV IgM detection. However, the molecular based approaches played very crucial role in HEV detection. It is observed that the incidence of HEV is gradually expanding and its objective range is not only just developing countries, but also showing an enhancement. In overall, there is need for improvements in detection of HEV disease and methodologies used for the development of HEV vaccines.

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Hepatitis E virus infection in HIV‐infected patients: A large cohort study in Yunnan province, China

Cited by 14 publications

References 33 publications

Hepatitis E Infection in HIV-Infected Patients

Hepatitis E Infection in HIV-Infected Patients

Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012–2014)

Hepatitis E: Current Status in India and Other Asian Countries

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