Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana

Adjei, Andrew A.; Tettey, Yao; Aviyase, John T; Adu-Gyamfi, Clement; Obed, Samuel A.; Mingle, J. A. A.; Ayeh‐Kumi, Patrick F.; Adiku, Theophilus

doi:10.1186/1743-422x-6-108

Cited by 65 publications

(71 citation statements)

References 22 publications

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“…Our finding, though higher than 0% rate reported in a similar cohort in France [45], is lower than rates ranging from 2.6% to 33% recorded by several authors in a similar cohort in different regions of the world [46][47][48][49][50]. Variation in the performance of different ELISA kits employed in these studies may account for the difference in rates reported.…”

Section: Discussioncontrasting

confidence: 56%

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Ijeoma

Faleye

Bakarey

et al. 2017

Preprint

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Hepatitis E virus (HEV) remains a major public health concern in resource limited regions of the world. Yet data reporting is suboptimal and surveillance system is inadequate. In Nigeria, there is dearth of information on prevalence of acute HEV infection. This study was therefore designed to describe acute HEV infection among antenatal clinic attendees and community dwellers from two geographical regions in Nigeria. Seven hundred and fifty plasma samples were tested for HEV IgM by Enzyme Linked Immunosorbent Assay (ELISA) technique. The tested samples were randomly selected from a pool of 1,115 blood specimens previously collected for viral hepatitis studies among selected populations (pregnant women, 272; Oyo community dwellers, 438; Anambra community dwellers, 405) between September 2012 and August 2013. One (0.4%) pregnant woman in her 3rd trimester had detectable HEV IgM, while community dwellers from the two study locations had zero prevalence rates of HEV IgM. Detection of HEV IgM in a pregnant woman, especially in her 3rd trimester, is of clinical and epidemiological significance. The need therefore exists for establishment of a robust HEV surveillance system in Nigeria and especially amidst the pregnant population in a bid to improve maternal and child health.

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Section: Discussioncontrasting

confidence: 56%

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Ijeoma

Faleye

Bakarey

et al. 2017

Preprint

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“…Reports from Africa demonstrated a rate of 12% in Tunisia (17), 14% in Gabon (18), 28% in Ghana (19), and 84% in Egypt (20) for anti-HEV seroprevalence among pregnant women. In addition, a study in Indian pregnant women showed a prevalence of 33% for anti-HEV seropositivity (21).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Antibodies to Hepatitis E Virus Among Pregnant Women

Mamani¹,

Zamani²,

Hashemi³

et al. 2015

Avicenna J Clin Microbiol Infect

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Background: Hepatitis E virus (HEV) infection is a major public health problem in developing countries, which could progress to an acute self-limited hepatitis. Young adults and middle-aged people are more likely to be infected than children and elderly persons. The disease is usually mild in general population; severe infection is more seen among pregnant women and leads to a high rate of mortality in this population. Objectives: This study aimed to assess seroprevalence of HEV infection and related risk factors among pregnant women referred to Fatemieh Hospital in Hamadan, Iran. Patients and Methods: A total of 1050 pregnant women were included in this prospective cross-sectional study, conducted from 2010 to 2011. Anti-HEV specific IgG was measured with ELISA method. A questionnaire containing research purposes was also fulfilled for each participant. Results:The mean age of pregnant women was 27.2 ± 5.6 years. The overall seroprevalence of anti-HEV was 7.4%. There was a significant association between anti-HEV seropositivity and age (P < 0.001), degree of education (P = 0.017), number of household members (P = 0.002), siblings (P = 0.005), and parities (P = 0.007). However, no significant relationship was observed between positive anti-HEV and variables such as place of residence, occupation, history of animal contacts, agricultural activities, type of drinking water, and the method of washing vegetables (P > 0.05). Conclusions: According to the results, 92.6% of pregnant women were anti-HEV negative. However, there is no available effective vaccine for its prevention in human yet. Therefore, education about environmental and personal hygiene before and during pregnancy may be helpful for decreasing the rate of HEV infection in this high risk population.

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“…While there is much published literature on HEV infection during pregnancy from other African countries, 11,12 there are few published data on HEV infection during pregnancy in Sudan. 13,14 The current study was conducted to investigate the epidemiology, and maternal and perinatal outcomes of HEV infection among pregnant women at Port Sudan Hospital, Eastern Sudan to provide a better understanding of maternal and perinatal outcomes of communicable diseases in general, as well as viral hepatitis, during pregnancy in this region of Sudan.…”

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confidence: 99%

An outbreak of hepatitis E and high maternal mortality at Port Sudan, Eastern Sudan

Rayis

Jumaa

Gasim

et al. 2013

Pathogens and Global Health

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During 4 months (November 2010-March 2011) of an outbreak of hepatitis E virus (HEV), 39 pregnant women presented at Port Sudan Hospital, Sudan, with various symptoms of viral hepatitis. The diagnosis of viral hepatitis was confirmed by serology using ELISA anti-HEV IgG and IgM. The mean (SD) maternal age and gestational age were 24.0 (4.2) years and 33.6 (3.7) weeks, respectively. Eight (20.5%) women were primigravidae. There were 11 (28.2%) maternal deaths, 14 (36.0%) intrauterine fetal deaths, and eight (20.5%) cases of postpartum haemorrhage. There were nine (23.0%) cases of preterm (,37 weeks of gestation) deliveries. Fulminant hepatitis with hepatic encephalopathy was the most common cause of death among these patients. Nine of these women died before delivery and the other two died immediately following the delivery due to severe haemorrhage. There were no significant differences in clinical and biochemical data between the women who died (11) and those who survived.

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Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana

Abstract: Consistent with similar studies worldwide, the results of our studies revealed a high prevalence of HEV infection in pregnant women.

Cited by 65 publications

References 22 publications

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Acute Hepatitis E Virus infection in two geographical regions of Nigeria

Seroprevalence of Antibodies to Hepatitis E Virus Among Pregnant Women

An outbreak of hepatitis E and high maternal mortality at Port Sudan, Eastern Sudan

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