Hepatitis E virus infection may be transmitted through blood transfusions in an endemic area

Khuroo, Mohammad Sultan; Kamili, Saleem; Yattoo, Ghulam Nabi

doi:10.1111/j.1440-1746.2004.03437.x

Cited by 192 publications

(168 citation statements)

References 23 publications

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“…Further, Kamar et al suggested that HEV infection in kidney transplant recipients is more severe that HCV infection [17][28]. Some studies have proposed blood transfusion as a potential route of HEV transmission, particularly in areas of high endemicity [14][15][29]. However, in this study, we did not find any correlation between a history of blood transfusion and HEV infection.…”

Section: Discussioncontrasting

confidence: 77%

Seroprevalence of Hepatitis E among Iranian Renal Transplant Recipients

Khameneh

Sepehrvand²,

Masudi

2011

Hepat Mon

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BackgroundRenal transplant recipients are known to be susceptible to viral infections, with more severe clinical presentations compared to healthy persons. Hepatitis E is generally a self-limited disease, which is caused by hepatitis E virus. Recently, hepatitis E has become more important in organ transplant recipients, because of new findings regarding the potential for chronic infections in this patient group.ObjectivesThis study aimed to evaluate the seroprevalence of anti-HEV IgG among kidney transplant recipients in Urmia, in the north-western region of Iran.Patients and Methods91 patients were selected randomly from amongst patients who had undergone kidney transplantation in Urmia, Iran. Each patient was tested for the presence of anti-HEV IgG antibody using an enzyme-linked immunosorbent assay (ELISA, Dia.Pro; Diagnostic Bioprobes, Italy).Results28 subjects (30.8%) were seropositive for anti-HEV IgG. Seropositive patients were generally older than seronegative patients (P = 0.009). There was no correlation between HEV infection and the level of education (P = 0.206), the history of blood transfusion (P = 0.164), or history of pre-transplantation hemodialysis (P = 0.228). There was no significant difference in the serum alanine aminotransferase (ALT) levels of the anti-HEV seropositive and seronegative patients. Multinomial logistic regression analysis indicated no significant relationship between HEV infection and increase in ALT levels, even after controlling for treatment with azathioprine (P = 0.79, OR = 1.12; 95% CI: 0.45–2.76).ConclusionThe anti-HEV IgG antibody has a high prevalence in Iranian kidney transplant recipients, and it is significantly higher in comparison with previous studies in the general population or in hemodialysis patients.

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Section: Discussioncontrasting

confidence: 77%

Seroprevalence of Hepatitis E among Iranian Renal Transplant Recipients

Khameneh

Sepehrvand²,

Masudi

2011

Hepat Mon

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“…A proportion of healthy blood donors in endemic regions have detectable HEV viremia and transfusion of their blood has been shown to lead to HEV infection among recipients. 50 Similarly, a proportion of babies born to mothers with acute hepatitis E during the third trimester of pregnancy have showed evidence of HEV infection in the form of detectable HEV RNA or IgM anti-HEV antibodies in cord blood. 51 However, the contribution of these routes to the overall burden of hepatitis E appears to be small.…”

Section: Reservoir Of Infection and Routes Of Transmissionmentioning

confidence: 99%

Hepatitis E: Epidemiology and Natural History

Aggarwal

2013

Journal of Clinical and Experimental Hepatology

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“…Eine retrospektive Untersuchung von Transfusionsempfängern lässt vermuten, dass HEV in Endemiegebieten durch Transfusion übertragen werden kann [180]. Zu einem vergleichbaren Schluss kommt eine weitere Studie, in der gezeigt wurde, dass Transfusionsempfänger nach der Transfusion Marker einer HEV-Infektion aufwiesen [181]. In Ägypten, einem Land mit einer hohen HEV-Antikörperprävalenz von bis zu 80 % in der ländlichen Bevöl-kerung, wiesen 2/760 Spenden (0,26 %) HEV-RNA auf [182].…”

Section: Prävalenz Und Inzidenz Bei Spenderkollektivenunclassified

“…Über transfusionsassoziierte HEV-Übertragun-gen wurde aus Saudi-Arabien berichtet, einem Land, in dem HEV-1 endemisch ist [181]. Erste Berichte aus Japan, das nicht als HEV-Endemiegebiet eingestuft wird, über transfusionsassoziierte HEV-Infektionen erfolgten etwa zeitgleich [188,190].…”

Section: üBertragbarkeitunclassified