Hepatitis Following Injection of Mumps Convalescent Plasma

Outbreak of Hepatitis in a Diabetic Clinic

“…Similar conclusions are suggested by two instances of apparent spread to contacts who did not attend the diabetic clinic. The incubation period in the first case suggests that the disease was infective hepatitis, while the second is perhaps another instance of the long incubation period occasionally observed in the contacts of cases of homologous serum hepatitis (Propert, 1938;Beeson, Chesney, and McFarlan, 1944;Neefe et al, 1944).…”

“…There were no instances of second attacks to suggest the activity in this epidemic of two immunologically disttnct icterogenic agents, and the data available suggest an identity rather than a difference between the agents of infective hepatitis and homologous serum hepatitis. This may, however, apply only to the present epidemic, because other workers have recorded data suggesting differences between the agents (Witts, 1944;Beeson, Chesney, and McFarlan, 1944). Graham (1938) published the first account of an epidemic of jaundice in a diabetIc clinic.…”

Viral Hepatitis

“…The strongest supporting evidence is derived from the results of protection and cross-protec tion tests carried out by a number of investigators (1)(2)(3)(4)(5)(6)(7)(8)(9). Basically, the findings indicate that some degree of protection against virus A develops following a previous natural or experimental attack, 286 B r i o d y .…”

Homologous Serum Hepatitis and Measles Prophylaxis

“…Findlay andMacCallum (1937, 1938) described cases due to the use of small amounts of human serum in yellow fever vaccfne, and outbreaks due to the same cause were noted by Fox et al (1942) in Brazil. Beeson et al (1944) reported 101 cases in 266 soldiers inoculated with mumps convalescent serum. Beeson (1943), Morgan and Williamson (1943), and Bradley, Loutit, and Maunsell (1944) published records of cases in peksons who had been transfused with whole blood or pooled plasma, and numerous reports have since appeared, including detailed follow-up investigations of groups of transfused persons by Spurling, Shone, and Vaughan (1946) and Lehane et al (1949) in Britain, andby Brightman andKorns (1947) in the United States of America.…”

“…Beeson et al (1944) reported 101 cases in 266 soldiers inoculated with mumps convalescent serum. Beeson (1943), Morgan and Williamson (1943), and Bradley, Loutit, and Maunsell (1944) published records of cases in peksons who had been transfused with whole blood or pooled plasma, and numerous reports have since appeared, including detailed follow-up investigations of groups of transfused persons by Spurling, Shone, and Vaughan (1946) and Lehane et al (1949) in Britain, andby Brightman andKorns (1947) in the United States of America. Apart from the outbreak described by the Ministry of Health, however, we have not foufd in the literature any other cases due to the administration of adult serum or plasma to measles contacts.…”