Hepatitis G virus in multitransfused thalassaemics from India

Panigrahi, Aswini K.; Saxena, Alka; Acharya, Subrat Kumar; Panda, Subrat Kumar

doi:10.1111/j.1440-1746.1998.tb00759.x

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…In this study, it was observed that all the Indian isolates of HGV clustered together on a distinct phylogenetic branch, suggesting that all isolates are genetically identical and showed maximum homology with the Chinese strain, in contrast with an earlier study from India which showed two strains with maximum homology with those from the USA [27]. This demonstrates that, because of high heterogeneity, strains from the same geographical area might belong to different lineages and show genetic relatedness to isolates from different parts of the world.…”

Section: Discussioncontrasting

confidence: 80%

Hepatitis-G Virus Infection in Multi-transfused Patients and Intravenous Drug Abusers: New Delhi Experience

et al. 2007

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Hepatitis G virus (HGV) is a newly described virus that has been implicated in transfusion-associated hepatitis. HGV-RNA indicating current infection has frequently been isolated from the sera of multi-transfused patients (MTPs) and that of intravenous drug abusers (IVDAs). There is insufficient data on its prevalence among these high-risk groups in India. Hence this study was designed to evaluate the prevalence of HGV infection in MTPs and IVDAs. A total of 90 (57 males and 33 females) MTPs and 65 (44 males and 21 females) IVDAs were recruited in the study. Patients' sera were tested for liver function profile, HGV-RNA, anti-HCV, HCV-RNA, HBsAg, and HBV-DNA. HGV-RNA was detected in 17.7% (16/90) MTPs and 23% (15/65) IVDAs, and 93.5% of our HGV-positive patients were found to be co-infected with either HBV (38.7%) or HCV (74.1%). The sero-prevalence of HBV was found out to be 40% and 21.5%, respectively, in the two groups, that of HCV was 32.2% and 32.3%, respectively, and dual infection was observed in 15.5% and 10.7% of the subjects, respectively. There were no statistically significant differences between the clinical, biochemical, and serological profiles of HGV-positive and negative patients. The prevalence of HGV infection in these high-risk groups is significantly higher than in controls. HGV is found to be co-infected more frequently with HCV than with HBV.

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Section: Discussioncontrasting

confidence: 80%

Hepatitis-G Virus Infection in Multi-transfused Patients and Intravenous Drug Abusers: New Delhi Experience

et al. 2007

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“…However, TTV and HGV infections were also recorded in as many as 24% and 4 % respectively of control subjects indicating involvement of non-parenteral routes of transmission (Schrotter et al, 2000;Okamoto et al, 1998). In the present study, prevalence of TTV and HGV co-infections with HCV infection among thalassemic subjects were found to be comparable to that reported in studies from India (Panigrahi, Saxena, Acharya & Panda, 1998;Asim, Potukuchi, Arora, Singh & Kar, 2008). Several studies based on liver enzyme profile concluded that neither HGV nor TTV has any pathogenic role in liver damage (Sampeitro et al,1997;Irshad, Joshi, Sharma & Dhar 2006;Matsumoto et al,1999).…”

Section: Discussionsupporting

confidence: 79%

Divergent Pro-Inflammatory Cytokine Response Induced by GB Virus C/ Hepatitis G virus (GBV-C/HGV) and Torque Teno Virus (TTV) Co-Infections in Hepatitis C Virus (HCV) Infected Thalassemia Patients

Verghese¹,

Arora²,

Sharma³

et al. 2018

JMBR

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Despite common incidence of GB virus C/Hepatitis G virus (GBV-C/HGV) and Torque Teno Virus (TTV) co-infections in subjects with Hepatitis C virus (HCV) infection, pathogenic role of these co-infections in HCV infected subjects has not been clear since studies have mostly been based on liver enzyme profile yielding variable results. Pro-inflammatory cytokines that participate in host immune response against viruses are generated as a consequence of triggering of related genes by Nuclear Factor Kappa B (NF-kB) that is a member of transcription family. Study of three pro-inflammatory cytokines e.g. interleukin 1 beta (IL-1β), Interleukin-6 (IL-6), interleukin-8 (IL-8) in a group of multi-transfused thalassemic subjects in relation to positivity for HCV, HGV and TTV infections showed elevated levels of these cytokines in serum as well as in supernatant of peripheral blood mononuclear cell (PBMCs) cultures in HCV-GBV-C/HGV co-infected subgroup compared to HCV mono-infected subgroup (p <0.05 for comparison of all three cytokines) while HCV-TTV co-infected subgroup showed lowering of these levels compared to HCV mono-infected subgroup (p <0.05 for comparison of all three cytokines). Levels of p65 component of NF-kB i.e.NF-kB p65 in nuclear extracts of lipopolysaccharide stimulated PBMCs correlated positively with the levels of pro-inflammatory cytokines in serum as well as that in supernatants of PBMC cultures in both HCV- GBV-C/HGV co-infected and HCV-TTV co-infected subgroups (p values ranging from <0.001 to 0.004). Levels of NF-kB p65 in nuclear extracts and levels of pro-inflammatory cytokines in serum as well as in supernatants of PBMC culture did not show any alteration compared to thalassemic subjects with HGV or TTV infections alone and healthy non-transfused subjects. Based on the inhibitory role of TTV on activation of NF-kB in TTV-HCV co-infected cases observed in the present study and the reported contribution of NF-kB towards development of hepatocellular carcinoma (HCC) due to establishment of chronicity, it may be worth evaluating if TTV or any component of TTV can be utilized as therapeutic vaccine against development of HCC in HCV infected subjects.

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Viral Hepatitis in India

Abraham

2012

Clinics in Laboratory Medicine

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Hepatitis G virus in multitransfused thalassaemics from India

Cited by 7 publications

References 18 publications

Hepatitis-G Virus Infection in Multi-transfused Patients and Intravenous Drug Abusers: New Delhi Experience

Hepatitis-G Virus Infection in Multi-transfused Patients and Intravenous Drug Abusers: New Delhi Experience

Divergent Pro-Inflammatory Cytokine Response Induced by GB Virus C/ Hepatitis G virus (GBV-C/HGV) and Torque Teno Virus (TTV) Co-Infections in Hepatitis C Virus (HCV) Infected Thalassemia Patients

Viral Hepatitis in India

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