Hepatitis in a Family Infected by Chlamydia Psittaci

Samra, Z; Pik, Arie; Guidetti-Sharon, Ahuva; Yona, E; Weisman, Y

doi:10.1177/014107689108400614

Cited by 12 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These were complement fixation tests (CFT), enzyme(−linked) immunosorbent assay tests (ELISA/EIA including recombinant ELISA), (micro-)immunofluorescence tests and whole cell immunofluorescence tests (IF/MIF/WHIF) and immuno-peroxidase tests (IPA). IF/MIF (including IPA [15, 31, 32] and WHIF [34]) was used in the majority of the articles (27/37, 73%), followed by CFT (20/37, 54%) and EIA/ELISA testing (5/37, 14%). CFT and IF were used regularly in outbreak investigations from 1985 up to 2014 in contrast to ELISA/EIA.…”

Section: Resultsmentioning

confidence: 99%

Laboratory methods for case finding in human psittacosis outbreaks: a systematic review

et al. 2018

View full text Add to dashboard Cite

BackgroundPsittacosis outbreak investigations require rapid identification of cases in order to trace possible sources and perform public health risk assessments. In recent outbreaks in the Netherlands, such investigations were hampered by the non-specificity of laboratory testing methods to identify human Chlamydia psittaci infections.MethodA systematic search of PubMed and Scopus databases of literature published between 01 January, 1986 and 03 July, 2017 was done to find best practices of laboratory-testing methods used in psittacosis outbreaks of two or more human cases. Reference lists of included articles were hand searched to identify additional articles.ResultsThirty-seven eligible articles were identified, describing 44 human psittacosis outbreaks in 12 countries. Laboratory tests performed were PCR (with various targets), serologic tests (complement binding reactions, ELISA’s, immunofluorescence tests and immuno-peroxidase tests) and culture, in various combinations. The literature provided no ‘gold standard’ laboratory testing strategy to identify recent human C. psittaci infections. In most psittacosis outbreaks, for a considerable number of cases (or tested individuals in an exposed cohort), C. psittaci infection could not be confirmed, nor excluded as causative pathogen. None of the testing strategies was found to be suitable for (nearly) full case finding.ConclusionPCR enables rapid identification of human psittacosis patients and helps source finding by genotyping but has the disadvantage that sensitivity is high only in the acute phase. In outbreak situations, there is often a time delay and therefore, there is a need for new serologic testing methods next to PCR, with good specificity and sensitivity. Moreover, serum is easier to collect than the preferred diagnostic materials for PCR. A serologic test that can reliably confirm infection status without the necessity of convalescent serum sampling would enhance case finding, source tracing, identification of risk factors and assessment of burden of disease in various settings.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3317-0) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultsmentioning

confidence: 99%

Laboratory methods for case finding in human psittacosis outbreaks: a systematic review

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There were a few reports of human psittacosis outbreaks in European countries, USA, Australia, Japan etc [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] . There were even fewer reports of family outbreaks of psittacosis 8,10,12,[43][44][45][46][47] Hitherto, there has been no report of an outbreak of human psittacosis from China, and nor family outbreak.…”

Section: Discussionmentioning

confidence: 99%

“…Other early outbreaks occured in Europe and Faroe Islands, which were traced to sick parrots and fulmar petrels. 3,6,7 Since Ritter's original description, there were only some scattered reports of family outbreaks of psittacosis [8][9][10][11][12]46 . However, there was no report of family outbreak of psittacosis in China until now.…”

Section: Introductionmentioning

confidence: 99%

Metagenomic next-generation sequencing in the family outbreak of psittacosis: the first reported family outbreak of psittacosis in China under COVID-19

Tan

et al. 2021

Emerging Microbes & Infections

View full text Add to dashboard Cite

Chlamydia psittaci infection in humans, also known as psittacosis, is usually believed to be an uncommon disease which mainly presents as community-acquired pneumonia (CAP). It is usually sporadic, but outbreaks of infection may occasionally occur. In outbreaks, diagnosis and investigations were usually hampered by the non-specificity of laboratory testing methods to identify C. psittaci. In this study, we use metagenomic next-generation sequencing (mNGS) in the diagnosis of a family outbreak of psittacosis under COVID-19. Three members of an extended family of 6 persons developed psittacosis with pneumonia and hepatic involvement with common symptoms of fever and weakness. Two newly purchased pet parrots which had died successively were probably the primary source of infection. Imagings show lung consolidations and infiltrates, which are difficult to be differentiated from CAP caused by other common pathogens. mNGS identified the infecting agent as C. psittaci rapidly within 48h. The results of this work suggest that there are not characteristic clinical manifestations and imagings of psittacosis pneumonia which can differentiate from CAP caused by other pathogens.The use of mNGS can improve accuracy and reduce the delay in diagnosis of psittacosis especially during the outbreak, which can shorten the course of the disease control. Family outbreak under COVID-19 may be related to the familial aggregation due to the epidemic. To our knowledge, this is the first reported family outbreak of psittacosis in China, and the first reported psittacosis outbreak identified by the method of mNGS in the world.

show abstract

“…Other symptoms described are non‐specific rash or gastro‐intestinal problems such as vomiting, abdominal pain and diarrhoea [37]. In rare cases, complications such as myocarditis, endocarditis [38], encephalitis [39], icterus [40], adult respiratory distress syndrome (ARDS) [41] and multi‐organ failure [42] have been described. Among pregnant women, atypical pneumonia, hepatitis, renal insufficiency, sepsis, premature birth or foetal death have been observed (overview in Refs [43,44]).…”

Section: Diagnosis Of Psittacosismentioning

confidence: 99%

Zoonotic Chlamydophila psittaci infections from a clinical perspective

Beeckman

Vanrompay

2009

Clinical Microbiology and Infection

242

203

View full text Add to dashboard Cite

Human psittacosis is a zoonotic infectious disease which is caused by the obligate intracellular bacterium Chlamydophila psittaci. Transmission of the disease usually originates from close contact with infected birds, most frequently in the context of the poultry industry, and from contact with Psittaciformes (cockatoos, parrots, parakeets and lories). Due to a low awareness of the disease and a variable clinical presentation psittacosis is often not recognised as such by general practitioners. This review therefore gives an overview of the epidemiology, symptoms, diagnosis and possible treatments for psittacosis in humans. The current case definition for epidemiological surveillance, as issued by the CDC, is discussed, as well as the possible emergence of Cp. psittaci antibiotic-resistant strains. There is an urgent need for information and for awareness campaigns directed at professional health care workers and the general public. In addition, a broader use of new diagnostic methods in medical laboratories and the development of prophylactics are called for.

show abstract

Hepatitis in a Family Infected by Chlamydia Psittaci

Cited by 12 publications

References 10 publications

Laboratory methods for case finding in human psittacosis outbreaks: a systematic review

Laboratory methods for case finding in human psittacosis outbreaks: a systematic review

Metagenomic next-generation sequencing in the family outbreak of psittacosis: the first reported family outbreak of psittacosis in China under COVID-19

Zoonotic Chlamydophila psittaci infections from a clinical perspective

Contact Info

Product

Resources

About