Hepatitis in vervet monkeys caused by Fusarium moniliforme

Jaśkiewicz, K.; Marasas, Walter F. O.; Taljaard, Jantjie

doi:10.1016/0021-9975(87)90092-2

Cited by 60 publications

(22 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar correlations also have been reported to exist in the Linxian area of China (Li et al, 1980;Lin & Tang, 1980;Yang, 1980). F. moniliforme is acutely toxic to pigs, sheep, horses, baboons (Kriek et ai, 1981), ducks (Engelhart et ai, 1989), chickens (Fritz et al, 1973;Sharby et al, 1973), turkeys (Engelhart et al, 1989), rats (Kriek et al, 1981) and monkeys (Jaskiewich et al, 1987). Utilizing a bioassay for the cancer-promoting activity of the MRC 826 strain of F. moniliforme as a guide, compounds named fumonisins Bi and B2 were isolated and chemically characterized (Bezuidenhout et al, 1988).…”

Section: Modeling Of Fb! Fb 2 Fb 3 and Hb-fbimentioning

confidence: 99%

“…This fungus has been linked to several human 0954-0105/95/020109-14 ©1995 Journals Oxford Ltd Downloaded by [University of Auckland Library] at 12:01 08 February 2015 and animal diseases (Li et al, 1980;Lin et al, 1980;Yang, 1980;Kriek et al, 1981;Marasas et al, 1984;Jaskiewich et al, 1987;Engelhart et al, 1989;Maruanovic et al, 1991). Crude extracts of cultured F. moniliforme have produced leukoencephalomalacia in horses and other equidae, pulmonary edema in swine and hepatotoxicity and hepatic tumors in horses, swine and rats (Kriek et al, 1981).…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Development of an improved monoclonal antibody‐based Elisa for fumonisin b_1–3and the use of molecular modeling to explain observed detection limits

Elissalde

Kamps‐Holtzapple

Beier

et al. 1995

Food and Agricultural Immunology

View full text Add to dashboard Cite

1995) Development of an improved monoclonal antibody-based Elisa for fumonisin b 1-3 and the use of molecular modeling to explain observed detection limits, Food and Agricultural Immunology, 7:2, 109-122, Monoclonal antibodies were prepared against the fumonisins, a group of mycotoxins produced by the plant pathogen, Fusarium moniliforme. Splenic lymphocytes, from Balb/c mice immunized with fumonisin B 1 -ovalbumin conjugate, were fused with SP2/O myeloma cells, and 14 hybridomas were selected. In a competitive enzyme-linked immunosorbent assay, fumonisin B 1 -bovine serum albumin and free fumonisin B 1 (FB 1 ) competed for the monoclonal antibody. The concentrations of FB 1 required to inhibit 50% antibody binding (IC 50 ) ranged from 300 to 670 ppb. Antibodies also cross-reacted with fumonisins B 2 and B 3 (FB 2 , FB 3 ), and the hydrolyzed backbone of fumonisin B 1 (HB-FB 1 ). None of the 14 monoclonal antibodies recognized the sphingolipids, sphingosine and sphinganine, that are structurally similar to the backbone of the fumonisins. Three-dimensional computer models of FB 1 , FB 2 and FB 3 show the amine backbone folding with the two esterified trimethylpropane-1,2,3-tricarboxylic acid side-chains to form a cage into which the hydroxyl and acid groups of these fumonisins extend. The HB-FB 1 molecule, with the two trimethylpropane-1,2,3-tricarboxylic acid esterified moieties at carbons 14 and 15 removed, does not possess two of the three branches which are folded together with inter-hydrogen bonding to formulate the three-dimensional structure that makes up the cage feature of FB 1 , FB 2 and FB 3 . Because of the unexpected folding of the three arms to make a cage of FB 1 , attachment of the protein to the amine group, which is close to, or appears to be pari of, the epitope, may have allowed the immune system of the mouse to produce antibodies more specific for the FB 1 -protein conjugate than to free FB 1 .

show abstract

Section: Modeling Of Fb! Fb 2 Fb 3 and Hb-fbimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Development of an improved monoclonal antibody‐based Elisa for fumonisin b_1–3and the use of molecular modeling to explain observed detection limits

Elissalde

Kamps‐Holtzapple

Beier

et al. 1995

Food and Agricultural Immunology

View full text Add to dashboard Cite

show abstract

“…We and others have experimentally reproduced the porcine pulmonary edema syndrome by feeding corn or corn screenings naturally contaminated with FB1 and by the intravenous (iv) administration of purified FB~ [9][10][11]. In these studies, liver and pancreatic injury were also reported [9-111 . Although the liver is affected in all species examined including horses [12], pigs [9][10][11], rats [13,14], and primates [15], other target organs appear to be more species specific. These are the lung and pancreas in pigs [9][10][11], brain in horses [12], and kidney in rats [13,14] and, perhaps, sheep [16].…”

Section: Introductionmentioning

confidence: 99%

Temporal and dose-response features in swine fed corn screenings contaminated with fumonisin mycotoxins

et al. 1994

View full text Add to dashboard Cite

Fumonisin B1 (FB1), a mycotoxin produced by Fusarium moniliforme and F. proliferatum, induces liver damage and pulmonary edema in swine. We examined the temporal and dose-response features of FB1 toxicosis in male weanling crossbred pigs fed nutritionally balanced diets, containing corn screenings naturally contaminated with fumonisins, for 14 days. Total fumonisins (FB1 and FB2) in diets 1 through 6 were assayed at 175, 101, 39, 23, 5, and < 1 ppm (below detectable concentrations), respectively. Clinical signs, serum biochemical alterations, and morphologic changes were evaluated. Pigs were weighed, and bled for hematologic and clinical chemistry evaluation on days 5 and 14. They were euthanized on day 14, or earlier if respiratory distress was observed. Respiratory distress developed in 3/5 pigs fed diet 1 between days 4 and 6 due to severe pulmonary edema and pleural effusion. Histologic evidence of hepatic injury was present in all pigs fed diets 1 and 2, 3/5 on diet 3, and 1/5 on diet 4. Serum bilirubin and cholesterol concentrations, gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and arginase (ARG) activities were elevated in pigs fed diets 1 and 2. Based on liver histopathology, the no observed adverse effect level (NOAEL) for fumonisin toxicity in swine was < 23 ppm total fumosins for the 14-day period. Based on regression analyses of the clinical chemistry profiles at 14 days, the NOAEL was < 12 ppm, with ALP being the most sensitive parameter. In conclusion, pulmonary edema occurred only at the highest fumonisin concentration (175 ppm), while liver damage occurred at much lower concentrations with a NOAEL of < 12 ppm.

show abstract

“…It has also been suggested that fumonisins are a risk factor for liver cancer (29), and FB 1 , like some F. moniliforme isolates (30,31), was hepatocarcinogenic when fed (50 ppm) to male BD IX rats (32). Studies are limited, but hepatotoxicity and atherogenic serum lipid profiles, perhaps secondary to liver dysfunction, were found in nonhuman primates fed diets containing fumonisin (13,33,34). Finally, a possible link between fumonisin exposure and neural tube defects in humans has been proposed (35).…”

mentioning

confidence: 99%

An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme.

Voss

Riley

Norred

et al. 2001

Environ Health Perspect

122

View full text Add to dashboard Cite

Fumonisins are produced by Fusarium moniliforme F. verticillioides) and other Fusarium that grow on corn worldwide. They cause fatal toxicoses of horses and swine. Their effects in humans are unclear, but epidemiologic evidence suggests that consumption of fumonisin-contaminated corn contributes to human esophageal cancer in southern Africa and China. Much has been learned from rodent studies about fumonisin B1(FB1), the most common homologue. FB1 is poorly absorbed and rapidly eliminated in feces. Minor amounts are retained in liver and kidneys. Unlike other mycotoxins, fumonisins cause the same liver cancer promotion and subchronic (studies (3/4) 90 days) liver and kidney effects as (italic)F. moniliforme. FB 1 induces apoptosis of hepatocytes and of proximal tubule epithelial cells. More advanced lesions in both organs are characterized by simultaneous cell loss (apoptosis and necrosis) and proliferation (mitosis). Microscopic and other findings suggest that an imbalance between cell loss and replacement develops, a condition favorable for carcinogenesis. On the molecular level, fumonisins inhibit ceramide synthase, and disrupt sphingolipid metabolism and, theoretically, sphingolipid-mediated regulatory processes that influence apoptosis and mitosis. Liver sphingolipid effects and toxicity are correlated, and ceramide synthase inhibition occurs in liver and kidney at doses below their respective no-observed-effect levels. FB1 does not cross the placenta and is not teratogenic in vivoin rats, mice, or rabbits, but is embryotoxic at high, maternally toxic doses. These data have contributed to preliminary risk evaluation and to protocol development for carcinogenicity and chronic toxicity studies of FB1 in rats and mice.

show abstract

Hepatitis in vervet monkeys caused by Fusarium moniliforme

Cited by 60 publications

References 11 publications

Development of an improved monoclonal antibody‐based Elisa for fumonisin b_1–3and the use of molecular modeling to explain observed detection limits

Development of an improved monoclonal antibody‐based Elisa for fumonisin b_1–3and the use of molecular modeling to explain observed detection limits

Temporal and dose-response features in swine fed corn screenings contaminated with fumonisin mycotoxins

An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme.

Contact Info

Product

Resources

About

Hepatitis in vervet monkeys caused by Fusarium moniliforme

Cited by 60 publications

References 11 publications

Development of an improved monoclonal antibody‐based Elisa for fumonisin b1–3and the use of molecular modeling to explain observed detection limits

Development of an improved monoclonal antibody‐based Elisa for fumonisin b1–3and the use of molecular modeling to explain observed detection limits

Temporal and dose-response features in swine fed corn screenings contaminated with fumonisin mycotoxins

An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme.

Contact Info

Product

Resources

About

Development of an improved monoclonal antibody‐based Elisa for fumonisin b_1–3and the use of molecular modeling to explain observed detection limits

Development of an improved monoclonal antibody‐based Elisa for fumonisin b_1–3and the use of molecular modeling to explain observed detection limits