Hepatitis of unknown origin in children: Updated evidence and concise review

Abstract

The rapid emergence of severe acute hepatitis across several European countries and several geographical regions in the United States has created panic among health institutions, local authorities, governmental organizations and regulatory bodies. Early reporting, stringent surveillance and supportive care can temporarily help tackle this crisis. However, definitive containment measures and management require characterization of the clinical spectrum, epidemiological assessment and extensive investigations. Furthermore, a sound management strategy requires randomized trials to explore the treatment options.

MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology

“…Until now, 26 children required liver transplantation, whereas 10 died. 6 To date, liver replacement is the sole successful procedure for diseases causing cirrhosis and consecutively organ failure in end-stage disease. 7 Despite rescue potential, liver transplantation remains a non-specific approach that is limited by donor organ shortage and a life-long immunosuppressive therapy with related risks.…”