Hepatitis Viruses in Heamodialysis Patients: An Added Insult to Injury?

Kosaraju, Kranthi; Faujdar, Sameer Singh; Singh, Aashima; Attur, Ravindra Prabhu

doi:10.1155/2013/860514

Cited by 12 publications

(7 citation statements)

References 19 publications

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“…This may be due to sample size, the method of detection and screening blood for antibodies against HCV with control measures in hospitals. Double infection with two viruses (HBV and HCV) in the same patient were not detected in our study while in other studies were 4.4% [ 26 , 27 ]. The lower number of the patients who were positive for anti- HCV after one year of follow-up was due to their deaths.…”

Section: Discussioncontrasting

confidence: 71%

Seroprevalence occurrence of viral hepatitis and HIV among hemodialysis patients

Kamal

Mahdi

2018

Annals of Medicine and Surgery

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BackgroundPatients with chronic renal failure (CRF) were on maintenance invasive hemodialysis (HD) procedure. This procedure by itself affects immunity of the patients and became more susceptible to viral infections.Aim of the studyto investigate the occurrence of HBV, HCV and HIV infections in patients with hemodialysis.Patients and methodsA retrospective study of 430 end-stage renal failure patients, referred to hemodialysis department at XXXX Teaching Hospital, Baghdad-Iraq from January-2015 to January-2017. Patients were investigated for HBs-Ag using enzyme-labeled antigen test (Foresight-EIA-USA), HCV- Abs (IgG) specific immunoglobulin using an HCV enzyme-labeled antigen test (Foresight-EIA-USA)and anti - HIV Abs (IgG) using enzyme-labeled antigen test (Foresight-EIA-USA).ResultsThe frequency of HBV infection in the first year was not significant between males (1.11%) and females (0.00%) (P = 0.295). About HCV also there are no significant differences between males (12.63%) and females (9.31%) (P = 0.347). After one year of follow up the frequencies of HBV and HCV were not significant between two sexes. Additionally, no any one of the patients had HIV infection.ConclusionsThis study brings a light on that HBV and HCV were having the same frequencies in both genders and lower occurrence with time. Furthermore, HIV was not detected in those patients.

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Section: Discussioncontrasting

confidence: 71%

Seroprevalence occurrence of viral hepatitis and HIV among hemodialysis patients

Kamal

Mahdi

2018

Annals of Medicine and Surgery

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“…A recent study by Kosaraju et al highlights the duration of dialysis as an important risk factor for infection among haemodialysis patients. 17 This observation was in agreement with previous reports in Palestine, Moldavia, and other studies from different regions of the world. [20][21][22][23] Duration of dialysis is an important risk factor for acquiring infections as it is related to nosocomial transmission and dissemination of the infections in the dialysis units.…”

Section: Discussionsupporting

confidence: 93%

“…In a recent study conducted by Kumar et al seroconversion rates for hepatitis C have been reported as 7.44% where as a high seroconversion rate of 14.4 % was reported in a study conducted by Mittal et al 12,13 Kosaraju et al in their study reported a very low prevalence and seroconversion rate of hepatitis B and C. 17 Similarly, we also found a low seroconversion rate of hepatitis C (4.8%) at our dialysis centre.…”

Section: Discussionsupporting

confidence: 78%

“…[20][21][22][23] Duration of dialysis is an important risk factor for acquiring infections as it is related to nosocomial transmission and dissemination of the infections in the dialysis units. 17 While analyzing patients who seroconverted, number of blood transfusions received significantly contributed to development of either hepatitis B or C infection in our study. Several studies have shown that the risk of acquiring the HCV infection increased with an increase in the number of units of blood which were transfused.…”

Section: Discussionmentioning

confidence: 98%

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Prevalence, Seroconversion and Risk Factors of Hepatitis B and C Infection in Patients on Maintenance Hemodialysis

Makkar¹,

Gupta²,

Bansal³

et al. 2014

jemds

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BACKGROUND: HBV and HCV infections pose a great threat to patients on hemodialysis and studies have been conducted regarding the prevalence and seroconversion rates. The present study was conducted to demonstrate the prevalence and seroconversion rate in patients with chronic hemodialysis and also the incidence of liver function derangement in patients with Hepatitis B and C. METHODS: HBV and HCV status of patients who were on hemodialysis irrespective of serological status and etiology of renal failure were observed. 205 patients were followed up for a period of one year and the incidence, prevalence and seroconversion of HBV and HCV was estimated through HbsAg and Anti-HCV ELISA tests. T-test was used to compare different biochemical and other parameters among two groups (Reactive and Non-reactive). Linear regression was used to calculate the relationship between the parameters and seroconversion rates. RESULTS: 205 patients were observed in the study. The prevalence and seroconversion rates were 11.22% and 4.8% in HBV patients and 18.54% and 6.8% in HCV patients respectively, at the end of the study. There was a significant correlation of the prevalence with average number of blood transfusion and elevated ALT levels in HbsAg reactive patients. Additionally, anti-HCV reactive patients correlated significantly with average number of blood transfusion and elevated ALT levels. There was significant correlation with mean duration of haemodialysis and i.v drug abuse in anti-HCV reactive patients. Regarding the seroconversion status only the average number of blood transfusions was having a significant correlation in both HbsAg and anti-HCV reactive patients. CONCLUSION: The prevalence and seroconversion rates were 11.22% and 4.8% in HBV patients and 18.54% and 6.8% in HCV patients respectively. Safety can be improved with the availability of more sensitive tests, increasing use of erythropoietin, timely vaccination for hepatitis B and adopting universal precautions.

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“…(4) In addition, hemodialysis patients are usually anemic, need blood transfusion and invasive procedures more than the general population which also put them at higher risk of being infected with these viruses. (5) Therefore, patients undergoing hemodialysis are expected to have the highest rates of hepatitis B virus and hepatitis C virus infections and this is exactly what has been confirmed by the great majority of epidemiological studies which showed prevalence of hepatitis B and hepatitis C infections in hemodialysis units ranges from 1-20% and 1-55% respectively. (6,(15)(16)(17)(18) The presence of hepatitis B virus and/or hepatitis C virus in patients with chronic kidney disease can also increase the morbidity and mortality in these patients.…”

Section: Introductionmentioning

confidence: 72%

Prevalence of Hepatitis B and C Viruses in Hemodialysis Patients at JRMS

Ghazzawi¹,

Yassin²,

Alshebly³

2015

JRMS

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Objective:The aim of our study is to evaluate the prevalence of hepatitis B and C viruses in hemodialysis patients at Royal Medical Services hospitals in Jordan for May 2014. In addition, to find out the risk factors associated with these infections.Methods: This is a cross sectional study which was carried out in 7 dialysis units at Jordanian Royal Medical Services in Jordan In May 2014. The notes of patients on maintenance hemodialysis were reviewed and the patients were interviewed by the researchers to collect data regarding the serology status of these patients and potential risk factors which could be associated with hepatitis B virus and hepatitis C virus infection. Results:A total of 712 patients were included in this study. Fifty six percent were males and their mean age was 48. The prevalence of hepatitis B virus was 7%. The prevalence of hepatitis C virus was 16.5%. Family history of hepatitis B infection and history of dialysis outside their specified units were found in 96% of patients with hepatitis B infection with a significant P-value <0.001, while history of hepatitis B vaccination was a strong protective factor against hepatitis B infection with a significant Pvalue of <0.001. Risk factors associated with hepatitis C infection were: age of the patient, duration of hemodialysis, dialysis outside, family history of hepatitis C, history of kidney transplant and dental procedures. Conclusion:Hepatitis B vaccination is of vital importance in prevention of hepatitis B infection in hemodialysis patients. Strict adherence to infection control guidelines as well as possible isolation of hepatitis C infected patients from other dialysis patients is essential to decrease the rate of hepatitis C and hepatitis B infections.

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Hepatitis Viruses in Heamodialysis Patients: An Added Insult to Injury?

Cited by 12 publications

References 19 publications

Seroprevalence occurrence of viral hepatitis and HIV among hemodialysis patients

Seroprevalence occurrence of viral hepatitis and HIV among hemodialysis patients

Prevalence, Seroconversion and Risk Factors of Hepatitis B and C Infection in Patients on Maintenance Hemodialysis

Prevalence of Hepatitis B and C Viruses in Hemodialysis Patients at JRMS

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