Hepatitis viruses take advantage of traditional practices to increase the burden of hepatocellular carcinoma in Tunisia

Dhifallah, Ines; Khedhiri, Marwa; Chouikha, Anissa; Kharroubi, Ghassen; Hammami, Walid; Sadraoui, A.; Azzouz, Mohamed Msaddek; Màamouri, N.; Khalfallah, Tahar; Triki, Henda; Pineau, Pascal; Bahri, Olfa

doi:10.1007/s00705-019-04440-5

Cited by 8 publications

(4 citation statements)

References 49 publications

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“…To our knowledge, this is the second observation of such drastic dichotomous distribution in SSA as it was observed 2 decades ago by Kirk and colleagues in Gambia ( 31 ). However, such divergent distribution has been recently described in Algeria and Tunisia ( 32 , 33 ). There is currently no clear explanation for this situation.…”

Section: Discussionmentioning

confidence: 97%

Drastic sex-dependent etiological distribution in severe liver diseases from Gabon

Moussavou-Boundzanga

Bignoumba²,

Mouinga‐Ondémé³

et al. 2022

Front. Oncol.

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Chronic liver diseases still represent a worrying public health issue in Sub-Saharan Africa. In this region, emphasis is generally made on hepatocellular carcinoma (HCC) albeit liver cirrhosis (LC) is also responsible for an important death toll. Very few studies have compared the presentation and etiologies of cancer and cirrhosis of the liver in Middle Africa. We conducted a comparative retrospective analysis of 74 and 134 cases of patients with HCC and LC treated in Libreville, Gabon. Viral or lifestyle risk factors, clinical symptoms, and biological features were compared. We observed that ages of diagnosis were 53.2 ± 15.7 years and 48.6 ± 18.6 years for HCC and LC with remarkably low M:F sex ratios (1.3-1.8). Ethanol consumption was highly prevalent in both disease types (65.0%-70.0%). Chronic viral infections with hepatitis B (HBV) or C (HCV) virus were also widespread with slight domination of the former in both diseases (43.4% vs. 34.3%, and 35.9% vs. 28.5%). Patients with HCC were presenting very late with a mean diameter of the main nodule of 84 ± 50 mm and a multifocal pattern in 72.7% of cases. HCC developed on a cirrhotic liver in 91.7% of cases. Serum AFP was frankly elevated (>400 ng/ml) in only 35.8% of HCC cases. The most striking feature of the HCC series was the contrasted contribution of distinct pathogenic etiologies involving sex, viral, metabolic, and toxic factors. A frequently dysmetabolic condition synergizing with hepatitis C (anti-HCV, 73.8% vs 22.7%, p < 0.0001) in females and a male cancer promoted by recreational toxicants and chronic hepatitis B (HBsAg, 83.5% vs 35.9%, p < 0.0001) were observed. Men with HCC were considerably younger than women (46.8 ± 14.5 years vs. 62.2 ± 12.2 years, p < 0.0001). Further studies are now warranted to identify routes of HCV transmission and if they are still fueling reservoirs of future patients. Public policies to prevent alcohol-related harm have also to be urgently implemented in Gabon.

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Section: Discussionmentioning

confidence: 97%

Drastic sex-dependent etiological distribution in severe liver diseases from Gabon

Moussavou-Boundzanga

Bignoumba²,

Mouinga‐Ondémé³

et al. 2022

Front. Oncol.

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“…Out of 238 published Case control studies, 95.37% were from Egypt (227 studies), 5 publications from Morocco (350)(351)(352)(353)(354), Single case control study was published from each of Sudan (355), Jordan (356), KSA (357), Syria (358), Tunisia (359) and single shared multicenter study between Tunisia, Morocco and Algeria (360).…”

Section: Case Control Studiesmentioning

confidence: 99%

Liver diseases among Arab world, current state and unmet needs, a scoping review

Almansoury,

Abdel-Gawad,

Abdelghani

et al. 2023

Global Gastroenterology

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“…Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer-related death worldwide (El-Serag and Kanwal 2014). Although HCC is closely related to chronic infection with hepatitis B virus and hepatitis C virus as well as to chronic liver damage (Dhifallah et al 2020 ), a general gut microbiota dysbiosis (Ni et al 2019 ) and an increase in 13 specific genera including Gemmiger and Parabacteroides were found in its early stages (Ren et al 2019 ).…”

Section: Gut Microbiota In Gi Cancermentioning

confidence: 99%

The Role of Gut Microbiota in Gastrointestinal Tract Cancers

Grochowska

Perlejewski

Laskus

et al. 2022

Arch. Immunol. Ther. Exp.

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Disturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain largely unclear. While some bacteria seem to facilitate carcinogenesis, others appear to be protective. So far only one bacterium (Helicobacter pylori) has been classified by the International Agency for Cancer Research as carcinogenic in humans but many other are the subject of intense research. Most studies on the role of microbiota in GI tract oncogenesis focus on pancreatic and colorectal cancers with the following three species: Helicobacter pylori, Escherichia coli, and Porphyromonas gingivalis as likely causative factors. This review summarizes the role of bacteria in GI tract oncogenesis.

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Hepatitis viruses take advantage of traditional practices to increase the burden of hepatocellular carcinoma in Tunisia

Cited by 8 publications

References 49 publications

Drastic sex-dependent etiological distribution in severe liver diseases from Gabon

Drastic sex-dependent etiological distribution in severe liver diseases from Gabon

Liver diseases among Arab world, current state and unmet needs, a scoping review

The Role of Gut Microbiota in Gastrointestinal Tract Cancers

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