Hepato-Preventive Effects of Hydroethanolic Leaves Extract of <i>Persea americana</i> Mill. (Lauraceae) “Avocado” against Antouka Super<sup>®</sup>Induced Damage in Male Japanese Quail (<i>Coturnix coturnix</i> Japonica)

Abstract

The present study was undertaken to evaluate the protective effects of Hydroethanolic leaves extract of Persea americana (HEPA) against Antouka Su-per® (AS) induced hepatotoxicity in male Japanese quail. In total, 40 immature male Japanese quails aged 28 days were used and divided equally into 5 groups. The groups were designed as the control group (received only a 10 ml/kg of distilled water) and the AS group (75 mg/kg b.w). Other three groups received AS (75 mg of AS/kg b.w) plus HEPA (50, 100, and 200 mg/kg b.w/day respectively) by the oral route. After 60 days of the experiment, the crushed liver was performed to obtain homogenate. The protective effects of HEPA on the biochemical parameters, oxidative stress biomarkers and histology changes in the liver were evaluated. The results indicated that AS treatment caused significant alterations in the clinical signs and behavior. It induces the increase in the content of Urea, Creatinine, Protein, AST and ALT in liver tissues and serum. The activities of enzymatic oxidative stress markers such as Superoxide Dismutase (SOD); Catalase (CAT) and Total Peroxidase (POD) also showed significant perturbations in AS-treated quails.